Research of Pharyngeal Paraesthesia in Female Climacterium_West China Medical Journal

Authors：

LIU Qingjun , YIN Jianping ,  ZHANG Lingyan , LUO Gang , DENG Wei , XU Bin

Department of Otolaryngology, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;

Corresponding author：

ZHANG Lingyan, Email: 54zly@163.com

Keywords：

更年期; 咽异感症; 病因学

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的　进一步探讨更年期咽异感症的发病机制，为正确的诊治该疾病提供新的思考。方法　试验组纳入2011年1月－2012年2月女性更年期咽异感症患者24例，年龄41～51岁；对照组纳入咽痛为主要表现的急慢性咽炎患者24例，年龄18～44岁。运用低浓度丁卡因溶液及氯霉素溶液喷雾咽腔，观察更年期咽异感症患者与急慢性咽炎患者用药后的治疗反应。结果　更年期咽异感症患者使用丁卡因后，咽部异物感症状普遍加重，而急慢性咽炎患者咽痛症状则有减轻，组间构成比差异具有统计学意义（χ2=25.552，P＜0.05）；氯霉素溶液喷雾后，两组患者差异无统计学意义（χ2=0.520，P＞0.05）。结论　局部炎症并非更年期咽异感症的真实原因，更年期感觉神经功能的快速退行性变所引起的感觉不适应，即咽部感觉神经功能的下降，可能是咽异感症的最本质原因，针对神经功能退行性变的处理，才是更年期咽异感症的最佳治疗方案。

Citation： LIU Qingjun,YIN Jianping,ZHANG Lingyan,LUO Gang,DENG Wei,XU Bin. Research of Pharyngeal Paraesthesia in Female Climacterium. West China Medical Journal, 2012, 27(9): 1346-1348. doi: Copy

1.	黄选兆, 汪吉宝. 实用耳鼻咽喉科学[M]. 北京: 人民卫生出版社, 2005: 328-329.
2.	况光仪, 易慧明, 吴克利, 等. 咽异感症临床分型及治疗的初步探讨 [J]. 中华耳鼻咽喉头颈外科杂志, 2006, 41(5): 355-358.
3.	Moraes SD, da Fonseca AM, Soares JM Jr, et al. Construction and validation of an instrument that breaks the silence: the impact of domestic and/or sexual violence on women’s health, as shown during climacterium. [J]. Menopause, 2012, 19(1): 16-22.
4.	Tchernev G, Cardoso J, Trafeli J, et al. Early syphilitic meningoencephalitis masquerading as postclimacteric endogenous depression--a unique dermatologic presentation[J]. Akush Ginekol, 2011, 50(2): 48-51.
5.	Dallanezi G, Nahas EA, Freire BF, et al. Quality of life of women with low bone mass in postmenopause[J]. Rev Bras Ginecol Obstet, 2011, 33(3): 133-138.
6.	Hofer HG. Men in a critical age: Kurt Mendel and the controversy over the male climacterium[J]. Urologe A, 2011, 50(7): 839-845.
7.	Szkutnik-Fiedler D, Jedrzejczyk M, Grześkowiak E, et al. The role of phytoestrogen therapy in relieving postmenopausal symptoms[J]. Ginekol Pol, 2010, 81(12): 929-934.
8.	Agosta C, Atlante M, Benvenuti C. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause[J].Minerva Ginecol, 2011, 63(1): 11-17.
9.	Nesteruk T, Nesteruk M, Bulik-Pasińska M, et al. Brainstem ischemic stroke without permanent sequelae during the course of spontaneous internal carotid artery dissection-case report[J]. Pol J Radiol, 2012, 77(1): 58-62.
10.	郭志祥,郭睿.重视咽异感症的诊治[J]. 中华耳鼻咽喉头颈外科杂志, 2005, 40(8): 638-640.
11.	Kirk HJ, Pik JH. A novel operative technique to manage a symptomatic synovial cyst associated with an os odontoideum[J]. J Clin Neurosci, 2009, 16(6): 822-824.
12.	王行炜. 600例难治性咽异感症患者病因分析 [J]. 临床耳鼻咽喉头颈外科杂志, 2006, 20(3): 129-131.
13.	Wadie GM, Konefal SH, Dias MA, et al. Cervical spondylodiscitis from an ingested pin: a case report[J]. J Pediatr Surg, 2005, 40(3): 593-596.
14.	葛丽荞. 以咽异感症为主要表现的真菌性食管炎23例临床分析 [J]. 临床耳鼻咽喉头颈外科杂志, 2007, 21(15): 712-713.
15.	Eder F, Meyer F, Huth C, et al. Penetrating abdomino-thoracic injuries: report of four impressive, spectacular and representative cases as well as their challenging surgical management[J]. Pol Przegl Chir, 2011, 83(3): 117-122.
16.	Boeckxstaens GE, Beaumont H, Mertens V, et al. Effects of lesogaberan on reflux and lower esophageal sphincter function in patients with gastroesophageal reflux disease[J]. Gastroenterology, 2010, 139(2): 409-417.
17.	Sedinkin AA, Balandin AV, Dimova AD. Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain[J].Ter Arkh, 2005, 77(3): 74-76.
18.	Wang KC, Chan WS, Tsai CT, et al. Lingual nerve injury following the use of an oropharyngeal airway under endotracheal general anesthesia[J]. Acta Anaesthesiol Taiwan, 2006, 44(2): 119-122.

1. 　黄选兆, 汪吉宝. 实用耳鼻咽喉科学[M]. 北京: 人民卫生出版社, 2005: 328-329.
2. 　况光仪, 易慧明, 吴克利, 等. 咽异感症临床分型及治疗的初步探讨 [J]. 中华耳鼻咽喉头颈外科杂志, 2006, 41(5): 355-358.
3. 　Moraes SD, da Fonseca AM, Soares JM Jr, et al. Construction and validation of an instrument that breaks the silence: the impact of domestic and/or sexual violence on women’s health, as shown during climacterium. [J]. Menopause, 2012, 19(1): 16-22.
4. 　Tchernev G, Cardoso J, Trafeli J, et al. Early syphilitic meningoencephalitis masquerading as postclimacteric endogenous depression--a unique dermatologic presentation[J]. Akush Ginekol, 2011, 50(2): 48-51.
5. 　Dallanezi G, Nahas EA, Freire BF, et al. Quality of life of women with low bone mass in postmenopause[J]. Rev Bras Ginecol Obstet, 2011, 33(3): 133-138.
6. 　Hofer HG. Men in a critical age: Kurt Mendel and the controversy over the male climacterium[J]. Urologe A, 2011, 50(7): 839-845.
7. 　Szkutnik-Fiedler D, Jedrzejczyk M, Grześkowiak E, et al. The role of phytoestrogen therapy in relieving postmenopausal symptoms[J]. Ginekol Pol, 2010, 81(12): 929-934.
8. 　Agosta C, Atlante M, Benvenuti C. Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause[J].Minerva Ginecol, 2011, 63(1): 11-17.
9. 　Nesteruk T, Nesteruk M, Bulik-Pasińska M, et al. Brainstem ischemic stroke without permanent sequelae during the course of spontaneous internal carotid artery dissection-case report[J]. Pol J Radiol, 2012, 77(1): 58-62.
10. 　郭志祥,郭睿.重视咽异感症的诊治[J]. 中华耳鼻咽喉头颈外科杂志, 2005, 40(8): 638-640.
11. 　Kirk HJ, Pik JH. A novel operative technique to manage a symptomatic synovial cyst associated with an os odontoideum[J]. J Clin Neurosci, 2009, 16(6): 822-824.
12. 　王行炜. 600例难治性咽异感症患者病因分析 [J]. 临床耳鼻咽喉头颈外科杂志, 2006, 20(3): 129-131.
13. 　Wadie GM, Konefal SH, Dias MA, et al. Cervical spondylodiscitis from an ingested pin: a case report[J]. J Pediatr Surg, 2005, 40(3): 593-596.
14. 　葛丽荞. 以咽异感症为主要表现的真菌性食管炎23例临床分析 [J]. 临床耳鼻咽喉头颈外科杂志, 2007, 21(15): 712-713.
15. 　Eder F, Meyer F, Huth C, et al. Penetrating abdomino-thoracic injuries: report of four impressive, spectacular and representative cases as well as their challenging surgical management[J]. Pol Przegl Chir, 2011, 83(3): 117-122.
16. 　Boeckxstaens GE, Beaumont H, Mertens V, et al. Effects of lesogaberan on reflux and lower esophageal sphincter function in patients with gastroesophageal reflux disease[J]. Gastroenterology, 2010, 139(2): 409-417.
17. 　Sedinkin AA, Balandin AV, Dimova AD. Results of an open prospective controlled randomized comparative trial of flurbiprofen and paracetamol efficacy and tolerance in patients with throat pain[J].Ter Arkh, 2005, 77(3): 74-76.
18. 　Wang KC, Chan WS, Tsai CT, et al. Lingual nerve injury following the use of an oropharyngeal airway under endotracheal general anesthesia[J]. Acta Anaesthesiol Taiwan, 2006, 44(2): 119-122.

West China Medical Journal

Research of Pharyngeal Paraesthesia in Female Climacterium

Abstract Full text Figures/Tables Video References Cited by

Format

Content