Pharmaceutical Practice Conducted by Clinical Pharmacists for a Patient with Erythama Multiforme Drug Eruption_West China Medical Journal

Authors：

XIAO Guirong ,  XU Ting

Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

XU Ting, Email: 407903196@qq.com

Keywords：

多形红斑型药疹; 链霉素; 临床药师; 药学监护

Video：

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目的　报道临床药师参与抗结核药物致结核性胸膜炎待诊患者多形红斑型药疹的临床药学实践的经验。方法　 1例结核性胸膜炎待诊患者在2011年11月3日出现皮疹后，临床药师根据患者的用药情况及病情变化，提供咨询意见，与临床医师共同制定不良反应的临床处理措施。结果　推断为链霉素所致的多形红斑型药疹，积极处理后患者病情好转。结论　临床药师参与药学监护，有利于处理药物不良反应。

Citation： XIAO Guirong,XU Ting. Pharmaceutical Practice Conducted by Clinical Pharmacists for a Patient with Erythama Multiforme Drug Eruption. West China Medical Journal, 2012, 27(9): 1372-1374. doi: Copy

1.	Adinma E, Ezeama NN, Umeokonkwo CD. Streptomycin-induced Steven-Johnson syndrome in a HIV sero-positive patient with tuberculosis: a case report[J]. Int J Clin Med, 2011, 2(4): 481-483.
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4.	聂爱华, 雷招宝. 15例链霉素致剥脱性皮炎型药疹不良反应分析[J]. 中国药物警戒, 2006, 3(6): 350-352.
5.	Tripathi A, Ditto AM, Grammer LC, et al. Corticostoeroid therapy in an additional 13 cases of Stevens-Johnson syndrome: a total series of 67 cases[J]．Allergy Asthma Proc, 2000, 21(2): 101-105.
6.	佟盼琢, 四荣联. 28例重症多形红斑临床回顾性分析[J]. 中国麻风皮肤病杂志, 2008, 24(10): 846-847.
7.	胡继荣, 李德宪, 尹仲. 重症多形红斑型药疹致敏药物及皮质类固醇激素对疗程的影响[J]. 贵阳医学院学报, 2007, 32(4): 433-434.
8.	许岚, 梁颖, 杨新建. 41例多形红斑型药疹的临床分析[J]. 天津药学, 2004, 16(1): 41-42.
9.	李琦, 孙莹, 段亚倩. 409例主要抗结核药不良反应文献分析[J]. 中国药房, 2008, 19(8): 620-621.
10.	冯红云, 陈易新. 4 750例抗结核药品不良反应分析[J]. 中国药物警戒, 2010, 7(12): 751-754.
11.	Girling DJ. Adverse effects of anti-tuberculosis drugs[J]. Drugs, 1982, 23(1-2): 56-74.
12.	郭述良, 罗永艾, 赵凤. 抗结核药物的严重不良反应[J]. 医药导报, 2002, 21(3): 145-147.
13.	Khalili B, Bahna SL. Pathogenesis and recent therapeutic trends in Stevens-Johnson syndrome and toxic epidermal necrolysis[J]. Ann Allergy Asthma Immunol, 2006, 97(3): 272-281.

1. 　Adinma E, Ezeama NN, Umeokonkwo CD. Streptomycin-induced Steven-Johnson syndrome in a HIV sero-positive patient with tuberculosis: a case report[J]. Int J Clin Med, 2011, 2(4): 481-483.
2. 　Sarkar SK, Purohit SD, Sharma TN, et al. Stevens Johnson syndrome caused by streptomycin[J]. Tubercle, 1982, 63(2):137-138.
3. 　赵秀文, 刘静, 耿彩荣. 链霉素致敏性的实验研究[J]. 抗生素, 1980, 5(6): 30-36.
4. 　聂爱华, 雷招宝. 15例链霉素致剥脱性皮炎型药疹不良反应分析[J]. 中国药物警戒, 2006, 3(6): 350-352.
5. 　Tripathi A, Ditto AM, Grammer LC, et al. Corticostoeroid therapy in an additional 13 cases of Stevens-Johnson syndrome: a total series of 67 cases[J]．Allergy Asthma Proc, 2000, 21(2): 101-105.
6. 　佟盼琢, 四荣联. 28例重症多形红斑临床回顾性分析[J]. 中国麻风皮肤病杂志, 2008, 24(10): 846-847.
7. 　胡继荣, 李德宪, 尹仲. 重症多形红斑型药疹致敏药物及皮质类固醇激素对疗程的影响[J]. 贵阳医学院学报, 2007, 32(4): 433-434.
8. 　许岚, 梁颖, 杨新建. 41例多形红斑型药疹的临床分析[J]. 天津药学, 2004, 16(1): 41-42.
9. 　李琦, 孙莹, 段亚倩. 409例主要抗结核药不良反应文献分析[J]. 中国药房, 2008, 19(8): 620-621.
10. 　冯红云, 陈易新. 4 750例抗结核药品不良反应分析[J]. 中国药物警戒, 2010, 7(12): 751-754.
11. 　Girling DJ. Adverse effects of anti-tuberculosis drugs[J]. Drugs, 1982, 23(1-2): 56-74.
12. 　郭述良, 罗永艾, 赵凤. 抗结核药物的严重不良反应[J]. 医药导报, 2002, 21(3): 145-147.
13. 　Khalili B, Bahna SL. Pathogenesis and recent therapeutic trends in Stevens-Johnson syndrome and toxic epidermal necrolysis[J]. Ann Allergy Asthma Immunol, 2006, 97(3): 272-281.

West China Medical Journal

Pharmaceutical Practice Conducted by Clinical Pharmacists for a Patient with Erythama Multiforme Drug Eruption

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