膀胱小细胞癌一例_West China Medical Journal

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何建萍 , 刘继彦 , 易成 , 毕锋 , 许峰

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Keywords：

膀胱肿瘤; 小细胞癌

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【摘要】　目的　总结膀胱小细胞癌的诊断及治疗。　方法　 2009年8月1例行根治性膀胱切除、回肠代膀胱术患者经病理学、免疫组织化学检查确诊为膀胱小细胞癌。患者接受EP治疗方案治疗。　结果　治疗4周期后，复查CT未见转移，无Ⅲ~Ⅳ级毒副反应。　结论　膀胱小细胞癌需依靠病理学及免疫组织化学检查确诊，治疗目前参考小细胞肺癌治疗方案，以化学疗法为主，复习文献得出有无手术切除并不影响膀胱小细胞癌患者的预后，靶向药物的治疗尚需进一步研究。

Citation： 何建萍,刘继彦,易成,毕锋,许峰. 膀胱小细胞癌一例. West China Medical Journal, 2011, 26(2): 246-247. doi: Copy

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1. 　Cramer SF, Aikawa M, Cebelin M. Neurosecretory granules in small cell invasive carcinoma of the urinary bladder[J]. Cancer, 1981, 47(4): 724-30.
2. 　Selli C, Gelmini S, Scott CA, et al. Evidence for elevated telomerase activity in small cell carcinoma of the bladder[J]. Urology, 2000, 56 (2): 331.
3. 　Holmang S, Borghede G, Johansson SL. Primary small cell car- cinoma of the bladder:a report of 25 cases[J]. J Urol, 1995, 153(6): 1820-1822.
4. 　Cheng L, Pan CX, Yang XJ, et al. Small cell carcinoma of the urinary bladder: a clinicopathologic analysis of 64 patients[J]. Cancer, 2004, 101(5): 957-962.
5. 　Abrahams NA, Moran C, Reyes AO, et al. Small cell carcinoma of the bladder: a contemporary clinicopathological study of 51 cases[J]. Histopathology, 2005, 46(1): 57-63.
6. 　曹志彬. 膀胱小细胞癌: 一种罕见的膀胱癌[J]. 国际泌尿系统杂志, 2006, 26(1): 25-28.
7. 　Bastús R, Caballero JM, González G, et al. Small cell carcinoma of the urinary bladder treated with chemotherapy and radiotherapy: resul tsin five cases[J]. Eur Urol, 1999, 35(4): 323-326.
8. 　Grignon DJ, Ro JY, Ayala AG, et al. Small cell car-cinoma of the urinary bladder. A clinicopathologic analysis of 22 cases[J]. Cancer, 1992, 69(2): 527-536.
9. 　潘进勇, 王晓维. 膀胱小细胞癌的研究进展[J]. 中华肿瘤防治杂志, 2007, 6(14): 864-865.
10. 　Abbas F, Civantos F, Benedetto P, et al. Small cell carcinoma of the bladder and prostate[J]. Urology, 1995, 6(5): 617-630.
11. 　Choong NW, Quevedo JF, Kaur JS. Small cell carcinoma of the urinary bladder. The Mayo Clinic experience[J]. Cancer, 2005, 103(6): 1172-1178.
12. 　Dreicer R, Manola J, Roth BJ, et al. Phase Ⅱ study of cisplatin and paclitaxel in advanced carcinoma of the urothelium: an Eastern Cooperative Oncology Group Study[J]. J Clin Oncol, 2000, 18(5): 1058-1061.
13. 　Bajorin DF, McCafrey JA, Dodd PM, et al. Ifosfamide, paclitaxel, and cisplatin for patients witll advanced transitional cell carcinoma of the urothelial tract: final report of a phase Ⅱ trial evaluating two dosing schedules[J]. Cancer, 2000, 88(7): 1671-1678.
14. 　Pan CX, Yang XJ, Lopez-Behran A, et al. c-kit-Expression in small cell carcinoma of the urinary bladder: prognostic and therapo utic implications[J]. Mod Pathol, 2005, 18(3): 320-323.
15. 　程亮, 黄文斌, 陈杰. 膀胱小细胞癌临床病理学和分子遗传学研究进展[J]. 中华病理学杂志, 2007, 36(10): 700-702.

West China Medical Journal

膀胱小细胞癌一例

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