【摘要】 目的 评价高效抗逆转录病毒疗法（highly active antiretroviral therapy，HAART）对艾滋病患者的疗效，并观察其耐药情况。 方法 2008年11月，对23例接受免费HAART治疗1~3年的艾滋病患者的HIV-RNA病毒载量、HIV-1耐药、CD4+T淋巴细胞绝对计数、常规生化检测结果进行分析。 结果 23例艾滋病患者在HAART治疗1~3年后有6例（26.1%）患者HIV-RNA载量在水平线以下，17例（73.9%）HIV-RNA载量未达到检测线以下。5例患者（21.7%）的HIV-1发生了耐药，服药依从性良好的患者仅9例（39.1%）。 结论 HAART对艾滋病患者的疗效较差、耐药率高、服药依从性差。
【Abstract】 Objective To evaluate the efficacy of highly active antiretroviral therapy (HAART) in treating HIV, and observe the resistance of HAART in AIDS patients. Methods Twenty-three HIV patients receiving free HAART for one to three years were investigated. The plasma viral load, drug resistance to HIV-1, CD4+ T cell count were tested and routine laboratory examinations were performed in our study. Results After one to fhnee-year HAART treatment, HIV viral load of six patients (26.1%) declined to the undetectable level, while the viral load of 17 patients (73.9%) kept at a high level. Resistance to HIV-1 occurred in five cases (21.7%). Only nine patients (39.1%) had good treatment compliance. Conclusion HAART has a poor therapeutic effect on patients with HIV/AIDS with a high rate of drug resistance and poor treatment compliance.
Citation： YANG Chengbin,FENG Ping,CEN Yihu,LIANG Cheng. Analysis of Effectiveness and Drug Resistance in Patients with AIDS Receiving Highly Active Antiretroviral Therapy. West China Medical Journal, 2011, 26(3): 424-426. doi: Copy