血管型轻度认知功能障碍的影像学研究进展_West China Medical Journal

Authors：

衣立业 ^1,2 , 蒋传路 ² ,  韩璎 ¹ , 贾建平 ¹

Corresponding author：

韩璎, Email: leaf850309@gmail.com

Keywords：

血管型轻度认知功能障碍; 小血管疾病; 血管性危险因素; 神经影像学

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Abstract Full text Figures/Tables Video References Cited by

【摘要】　血管型轻度认知功能障碍（vascular mild cognitive impairment，V-MCI）是与小血管疾病密切相关的MCI的一种亚型，是一组临床早期出现的处于正常老化与痴呆之间的过渡状态。近年来，随着影像学技术逐渐成熟并应用于临床研究，国内外很多学者从神经影像学角度对V-MCI患者进行了初步研究，发现其脑结构及功能均存在异常。文章综述了相关的研究进展，为进一步系统了解该病提供了重要依据。

Citation： 衣立业,蒋传路,韩璎,贾建平. 血管型轻度认知功能障碍的影像学研究进展. West China Medical Journal, 2011, 26(5): 777-780. doi: Copy

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15.	Meyer JS, Huang J, Chowdhury MH. MRI confirms mild cognitive impairments prodromal for Alzheimer’s, vascular and Parkinson-Lewy body dementias[J]. J Neurol Sci, 2007, 257 (1-2): 97-104.
16.	Kim SH, Park JS, Ahn HJ, et al. Voxel-based analysis of diffusion tensor imaging in patients with subcortical vascular cognitive impairment: correlates with cognitive and motor deficits[J]. J Neuroimaging,2010[2010-10-26]. http://onlinelibrary.wiley.com/doi/10.1111/j.1552-6569.2010.00527.x/abstract.
17.	Ginsberg SD, Martin LJ. Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neurons[J]. J Neurotrauma, 2002,19(1): 99-109.
18.	Johnson H, Cowey A. Transneuronal retrograde degeneration of retinal ganglion cells following restricted lesions of striate cortex in the monkey[J]. Exp Brain Res, 2000, 132(2): 269-275.
19.	Seo SW, Ahn J, Yoon U, et al. Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type[J]. J Neuroimaging, 2010, 20(1): 37-45.
20.	Seo SW, Cho SS, Park A, et al. Subcortical vascular versus amnestic mild cognitive impairment: comparison of cerebral glucose metabolism[J]. J Neuroimaging, 2009, 19(3): 213-219.
21.	Cummings JL. Frontal-subcortical circuits and human behavior[J]. J Psychosom Res, 1998, 44(6): 627-628.
22.	Kim JS, Singh V, Lee JK, et al. Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification[J]. Neuroimage, 2005, 27(1): 210-221.
23.	Singh V, Chertkow H, Lerch JP, et al. Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer’s disease[J]. Brain, 2006, 129(Pt 11): 2885-2893.
24.	Lyttelton O, Boucher M, Robbins S, et al. An unbiased iterative group registration template for cortical surface analysis[J]. Neuroimage, 2007, 34(4): 1535-1544.
25.	Boccardi M, Sabattoli F, Laakso MP, et al. Frontotemporal dementia as a neural system disease[J]. Neurobiol Aging, 2005, 26(1): 37-44.
26.	Zilbovicius M, Meresse I, Chabane N, et al. Autism, the superior temporal sulcus and social perception[J]. Trends Neurosci, 2006, 29(7): 359-366.
27.	Tomimoto H, Ohtani R, Shibata M, et al. Loss of cholinergic pathways in vascular dementia of the Binswanger type[J]. Dement Geriatr Cogn Disord, 2005, 19(5-6): 282-288.

1. 　Petersen RC, Smith GE, Waring SC, et al. Mild cognitive impairment: clinical characterization and outcome[J]. Arch Neurol, 1999, 56(3): 303-308.
2. 　Bowler JV. Vascular cognitive impairment[J]. J Neurol Neurosurg Psychiatry, 2005, 76(Suppl 5): 35-44.
3. 　Ringman JM, Medina LD, Rodriguez-Agudelo Y, et al. Current concepts of mild cognitive impairment and their applicability to persons at-risk for familial Alzheimer’s disease[J]. Curr Alzheimer Res, 2009, 6(4): 341-346.
4. 　Meyer JS, Quach M, Thornby J, et al. MRI identifies MCI subtypes: vascular versus neurodegenerative[J]. J Neurol Sci, 2005, 229-230: 121-129.
5. 　Brookmeyer R, Johnson E, Ziegler-Graham K, et al. Forecasting the global burden of Alzheimer’s disease[J]. Alzheimers Dement, 2007, 3(3): 186-191.
6. 　Pantoni L, Garcia JH. Pathogenesis of leukoaraiosis: a review[J]. Stroke, 1997, 28(3): 652-659.
7. 　Lammie GA. Pathology of small vessel stroke[J]. Br Med Bull, 2000, 56(2): 296-306.
8. 　Farias ST. Neuroimaging in non-Alzheimer dementias[J]. Clin Neurosci Res, 2004, 3(6): 383-395.
9. 　Kume K, Hanyu H, Sato T, et al. Vascular risk factors are associated with faster decline of Alzheimer disease: a longitudinal SPECT study[J/OL]. J Neurol,2011[2011-02-17]. http://www.springerlink.com/content/87qm685026255724/.
10. 　Magierski R, Kloszewska I, Sobow TM. The influence of vascular risk factors on the survival rate of patients with dementia with Lewy bodies and Alzheimer disease[J]. Neurol Neurochir Pol, 2010, 44(2): 139-147.
11. 　Prins ND, van Dijk EJ, den Heijer T, et al. Cerebral small-vessel disease and decline in information processing speed, executive function and memory[J]. Brain, 2005,128(Pt 9): 2034-2041.
12. 　Erkinjuntti T. Cognitive decline and treatment options for patients with vascular dementia[J]. Acta Neurol Scand Suppl,2002,178: 15-18.
13. 　Kalaria RN. Small vessel disease and Alzheimer’s dementia: pathological considerations[J]. Cerebrovasc Dis, 2002, 13(Suppl 2): 48-52.
14. 　Meyer JS, Huang J, Chowdhury M. MRI abnormalities associated with mild cognitive impairments of vascular (VMCI) versus neurodegenerative (NMCI) types prodromal for vascular and Alzheimer’s dementias[J]. Curr Alzheimer Res, 2005, 2(5): 579-585.
15. 　Meyer JS, Huang J, Chowdhury MH. MRI confirms mild cognitive impairments prodromal for Alzheimer’s, vascular and Parkinson-Lewy body dementias[J]. J Neurol Sci, 2007, 257 (1-2): 97-104.
16. 　Kim SH, Park JS, Ahn HJ, et al. Voxel-based analysis of diffusion tensor imaging in patients with subcortical vascular cognitive impairment: correlates with cognitive and motor deficits[J]. J Neuroimaging,2010[2010-10-26]. http://onlinelibrary.wiley.com/doi/10.1111/j.1552-6569.2010.00527.x/abstract.
17. 　Ginsberg SD, Martin LJ. Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neurons[J]. J Neurotrauma, 2002,19(1): 99-109.
18. 　Johnson H, Cowey A. Transneuronal retrograde degeneration of retinal ganglion cells following restricted lesions of striate cortex in the monkey[J]. Exp Brain Res, 2000, 132(2): 269-275.
19. 　Seo SW, Ahn J, Yoon U, et al. Cortical thinning in vascular mild cognitive impairment and vascular dementia of subcortical type[J]. J Neuroimaging, 2010, 20(1): 37-45.
20. 　Seo SW, Cho SS, Park A, et al. Subcortical vascular versus amnestic mild cognitive impairment: comparison of cerebral glucose metabolism[J]. J Neuroimaging, 2009, 19(3): 213-219.
21. 　Cummings JL. Frontal-subcortical circuits and human behavior[J]. J Psychosom Res, 1998, 44(6): 627-628.
22. 　Kim JS, Singh V, Lee JK, et al. Automated 3-D extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification[J]. Neuroimage, 2005, 27(1): 210-221.
23. 　Singh V, Chertkow H, Lerch JP, et al. Spatial patterns of cortical thinning in mild cognitive impairment and Alzheimer’s disease[J]. Brain, 2006, 129(Pt 11): 2885-2893.
24. 　Lyttelton O, Boucher M, Robbins S, et al. An unbiased iterative group registration template for cortical surface analysis[J]. Neuroimage, 2007, 34(4): 1535-1544.
25. 　Boccardi M, Sabattoli F, Laakso MP, et al. Frontotemporal dementia as a neural system disease[J]. Neurobiol Aging, 2005, 26(1): 37-44.
26. 　Zilbovicius M, Meresse I, Chabane N, et al. Autism, the superior temporal sulcus and social perception[J]. Trends Neurosci, 2006, 29(7): 359-366.
27. 　Tomimoto H, Ohtani R, Shibata M, et al. Loss of cholinergic pathways in vascular dementia of the Binswanger type[J]. Dement Geriatr Cogn Disord, 2005, 19(5-6): 282-288.

West China Medical Journal

血管型轻度认知功能障碍的影像学研究进展

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