【摘要】　目的　 观察单用二甲双胍与二甲双胍联合阿卡波糖对2型糖尿病（type 2 diabetes mellitus，T2DM）降糖作用的临床疗效。　方法　 对2010年1—10月就诊有典型易饥多食的T2DM患者45例，随机分为二甲双胍组20例和二甲双胍联合阿卡波糖25例，疗程12周。　结果　 二甲双胍组与二甲双胍联合阿卡波糖组治疗后对患者的饥饿感和食量改善差异有统计学意义（P lt;0.05），空腹及餐后血糖差异（P lt;0.01）、空腹血糖达标比例差异（P lt;0.01）、餐后血糖达标比例差异（P lt;0.05）均有统计学意义。　结论　 二甲双胍联合阿卡波糖能显著改善T2DM患者的食欲及食量，从而明显降低空腹及餐后血糖。
【Abstract】　Objective　 To observe and compare the clinical affects and curative effects between using metformin and metformin plus acarbose in the treatment of type 2 diabetes mellitus (T2DM).　Methods　 From January to October 2010, 45 T2DM patients with common symptoms of easy-starving and overeating were randomized into two groups and treated for 12 weeks with either metformin (n=20) or metformin plus acarbose (n=25).　Results　 After the treatment, significant differences were found between the two groups in the improvement on patients’ sense of starving and quantity of eating (P lt;0.05), fasting and postprandial blood glucose (P lt;0.01), up-to-standard rate of fasting blood glucose (P lt;0.01), and up-to-standard rate of postprandial blood glucose (P lt;0.05).　Conclusion　 The combination of metformin and acarbose can substantially improve the appetite and quantity of eating for patients with T2DM, hence significant reductions of fasting and postprandial blood glucose level can be feasibly achieved.

Citation： WU Xiaomei. Blood Glucose Reduction by Metformin plus Acarbose: Evaluation of the Clinical Affects and Curative Effects in Treating Type 2 Diabetes Mellitus. West China Medical Journal, 2011, 26(6): 832-834. doi: Copy