维生素D缺乏与糖尿病_West China Medical Journal

Authors：

李兰 ,  冉兴无

Corresponding author：

冉兴无, Email: 531698860@qq.com

Keywords：

维生素D; 糖尿病; 研究

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【摘要】　近来维生素D的骨外效应受到关注。除参与传统的钙磷代谢外，维生素D还具有广泛的生物学效应，进而可影响多种疾病的发病和进展。研究发现，维生素D具有调节免疫炎症过程，影响胰岛素的分泌和外周效应的作用；当体内维生素D缺乏时，免疫炎症细胞，胰岛β细胞以及胰岛素靶细胞功能将受到不同程度损害，由此导致的免疫紊乱、全身性炎症反应以及胰岛素的分泌和作用障碍均可能在糖尿病及其相关的糖代谢异常中发挥重要作用。

Citation： 李兰,冉兴无. 维生素D缺乏与糖尿病. West China Medical Journal, 2011, 26(6): 850-853. doi: Copy

1.	Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010, 362(12): 1090-1101.
2.	Hollis BW. Assessment of vitamin D status and definition of a normal circulating range of 25-hydroxyvitamin D[J]. Curr Opin Endocrinol Diabetes Obes, 2008, 15(6): 489-494.
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4.	Lu L, Yu Z, Pan A, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals[J]. Diabetes Care, 2009, 32(7): 1278-1283.
5.	Wat WZ, Leung JY, Tam S, et al. Prevalence and impact of vitamin D insufficiency in southern Chinese adults[J]. Ann Nutr Metab, 2007, 51(1): 59-64.
6.	Strand MA, Perry J, Zhao J, et al. Severe vitamin D-deficiency and the health of North China children[J]. Matern Child Health J, 2009, 13(1): 144-150.
7.	Baz-Hecht M, Goldfine AB. The impact of vitamin D deficiency on diabetes and cardiovascular risk[J]. Curr Opin Endocrinol Diabetes Obes, 2010, 17(2): 113-119.
8.	Johnson T, Avery G, Byham-Gray L. Vitamin D and Metabolic Syndrome[J]. Top Clin Nutr, 2009, 24(1): 47-54.
9.	Hickey L, Gordon CM. Vitamin D deficiency: new perspectives on an old disease[J]. Curr Opin Endocrinol Diabetes Obes, 2004, 11(1): 18-25.
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12.	Costello RB. Vitamin D and health in the 21st century: federal initiatives to advance research[J]. Am J Med Sci, 2009, 338(1): 34-39.
13.	Ponsonby AL, McMichael A, van der Mei I. Ultraviolet radiation and autoimmune disease: insights from epidemiological research[J]. Toxicology, 2002, 181-182: 71-78.
14.	Janner M, Ballinari P, Mullis PE, et al. High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes[J]. Swiss Med Wkly, 2010, 140: w13091.
15.	Littorin B, Blom P, Schölin A, et al. Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)[J]. Diabetologia, 2006, 49(12): 2847-2852.
16.	Knekt P, Laaksonen M, Mattila C, et al. Serum vitamin D and subsequent occurrence of type 2 diabetes[J]. Epidemiology, 2008, 19(5): 666-671.
17.	Barengolts E. Vitamin D role and use in prediabetes[J]. Endocr Pract, 2010, 16(3): 476-485.
18.	Gupta AK, Brashear MM, Johnson WD. Prediabetes and prehypertension in healthy adults are associated with low vitamin d levels[J]. Diabetes Care, 2011, 34(3): 658-660.
19.	Pino SC, Kruger AJ, Bortell R. The role of innate immune pathways in type 1 diabetes pathogenesis[J]. Curr Opin Endocrinol Diabetes Obes, 2010, 17(2): 126-130.
20.	Alonso N, Soldevila B, Sanmartí A, et al. Regulatory T cells in diabetes and gastritis[J]. Autoimmun Rev, 2009, 8(8): 659-662.
21.	Cnop M, Welsh N, Jonas JC, et al. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities[J]. Diabetes, 2005, 54 (Suppl 2): 97-107.
22.	廖岚, 周智广. 维生素D与自身免疫性糖尿病[J]. 国外医学•内分泌学分册, 2005, 25(2): 103-106.
23.	Marques CD, Dantas AT, Fragoso TS, et al. The importance of vitamin D levels in autoimmune diseases[J]. Rev Bras Reumatol, 2010, 50(1): 67-80.
24.	Riachy R, Vandewalle B, Moerman E, et al. 1, 25-Dihydroxyvitamin D3 protects human pancreatic islets against cytokine-induced apoptosis via down-regulation of the Fas receptor[J]. Apoptosis, 2006, 11(2): 151-159.
25.	沈字玲, 张能, 余华荣. 1, 25-二羟维生素D_3对1型糖尿病预防效果观察[J]. 四川生理科学杂志, 2006, 28(1): 26-28.
26.	McGill AT, Stewart JM, Lithander FE, et al. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity[J]. Nutr J, 2008, 7(1): 4.
27.	Alfonso B, Liao E, Busta A, et al. Vitamin D in diabetes mellitus-a new field of knowledge poised for D-velopment[J]. Diabetes Metab Res Rev, 2009, 25(5): 417-419.
28.	Kayaniyil S, Vieth R, Retnakaran R, et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes[J]. Diabetes Care, 2010, 33(6): 1379- 1381.
29.	Maghbooli Z, Hossein-Nezhad A, Karimi F, et al. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy[J]. Diabetes Metab Res Rev, 2008, 24(1): 27-32.
30.	Selimoglu H, Duran C, Kiyici S, et al. The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome[J]. J Endocrinol Invest, 2010, 33(4): 234-238.
31.	Pittas AG, Lau J, Hu FB, et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis[J]. J Clin Endocrinol Metab, 2007, 92(6): 2017-2029.
32.	Fujita T, Palmieri GM. Calcium paradox disease: calcium deficiency prompting secondary hyperparathyroidism and cellular calcium overload[J]. J Bone Miner Metab, 2000, 18(3): 109-125.
33.	Kamycheva E, Jorde R, Figenschau Y, et al. Insulin sensitivity in subjects with secondary hyperparathyroidism and the effect of a low serum 25-hydroxyvitamin D level on insulin sensitivity[J]. J Endocrinol Invest, 2007, 30(2): 126-132.
34.	Need AG, O’Loughlin PD, Horowitz M, et al. Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women[J]. Clin Endocrinol (Oxf), 2005, 62(6): 738-741.
35.	Bonakdaran S, Varasteh AR. Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients[J]. Saudi Med J, 2009, 30(4): 509-514.
36.	Hashemipour S, Larijani B, Adibi H, et al. The status of biochemical parameters in varying degrees of vitamin D deficiency[J]. J Bone Miner Metab, 2006, 24(3): 213-218.
37.	Guo SW, Magnuson VL, Schiller JJ, et al. Meta-analysis of vitamin D receptor polymorphisms and type 1 diabetes: a HuGE review of genetic association studies[J]. Am J Epidemiol, 2006, 164(8): 711-724.
38.	Bid HK, Konwar R, Aggarwal CG, et al. Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus: a North Indian study[J]. Indian J Med Sci, 2009, 63(5): 187-94.
39.	Palomer X, González-Clemente JM, Blanco-Vaca F, et al. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus[J]. Diabetes Obes Metab, 2008, 10(3): 185-197.

1. 　Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China[J]. N Engl J Med, 2010, 362(12): 1090-1101.
2. 　Hollis BW. Assessment of vitamin D status and definition of a normal circulating range of 25-hydroxyvitamin D[J]. Curr Opin Endocrinol Diabetes Obes, 2008, 15(6): 489-494.
3. 　Holick MF. Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers[J]. South Med J, 2005, 98(10): 1024-1027.
4. 　Lu L, Yu Z, Pan A, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals[J]. Diabetes Care, 2009, 32(7): 1278-1283.
5. 　Wat WZ, Leung JY, Tam S, et al. Prevalence and impact of vitamin D insufficiency in southern Chinese adults[J]. Ann Nutr Metab, 2007, 51(1): 59-64.
6. 　Strand MA, Perry J, Zhao J, et al. Severe vitamin D-deficiency and the health of North China children[J]. Matern Child Health J, 2009, 13(1): 144-150.
7. 　Baz-Hecht M, Goldfine AB. The impact of vitamin D deficiency on diabetes and cardiovascular risk[J]. Curr Opin Endocrinol Diabetes Obes, 2010, 17(2): 113-119.
8. 　Johnson T, Avery G, Byham-Gray L. Vitamin D and Metabolic Syndrome[J]. Top Clin Nutr, 2009, 24(1): 47-54.
9. 　Hickey L, Gordon CM. Vitamin D deficiency: new perspectives on an old disease[J]. Curr Opin Endocrinol Diabetes Obes, 2004, 11(1): 18-25.
10. 　Mathieu C. Vitamin D and diabetes: the devil is in the D-tails[J]. Diabetologia, 2010, 53(8): 1545-1548.
11. 　Danescu LG, Levy S, Levy J. Vitamin D and diabetes mellitus[J]. Endocrine, 2009, 35(1): 7-11.
12. 　Costello RB. Vitamin D and health in the 21st century: federal initiatives to advance research[J]. Am J Med Sci, 2009, 338(1): 34-39.
13. 　Ponsonby AL, McMichael A, van der Mei I. Ultraviolet radiation and autoimmune disease: insights from epidemiological research[J]. Toxicology, 2002, 181-182: 71-78.
14. 　Janner M, Ballinari P, Mullis PE, et al. High prevalence of vitamin D deficiency in children and adolescents with type 1 diabetes[J]. Swiss Med Wkly, 2010, 140: w13091.
15. 　Littorin B, Blom P, Schölin A, et al. Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)[J]. Diabetologia, 2006, 49(12): 2847-2852.
16. 　Knekt P, Laaksonen M, Mattila C, et al. Serum vitamin D and subsequent occurrence of type 2 diabetes[J]. Epidemiology, 2008, 19(5): 666-671.
17. 　Barengolts E. Vitamin D role and use in prediabetes[J]. Endocr Pract, 2010, 16(3): 476-485.
18. 　Gupta AK, Brashear MM, Johnson WD. Prediabetes and prehypertension in healthy adults are associated with low vitamin d levels[J]. Diabetes Care, 2011, 34(3): 658-660.
19. 　Pino SC, Kruger AJ, Bortell R. The role of innate immune pathways in type 1 diabetes pathogenesis[J]. Curr Opin Endocrinol Diabetes Obes, 2010, 17(2): 126-130.
20. 　Alonso N, Soldevila B, Sanmartí A, et al. Regulatory T cells in diabetes and gastritis[J]. Autoimmun Rev, 2009, 8(8): 659-662.
21. 　Cnop M, Welsh N, Jonas JC, et al. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities[J]. Diabetes, 2005, 54 (Suppl 2): 97-107.
22. 　廖岚, 周智广. 维生素D与自身免疫性糖尿病[J]. 国外医学•内分泌学分册, 2005, 25(2): 103-106.
23. 　Marques CD, Dantas AT, Fragoso TS, et al. The importance of vitamin D levels in autoimmune diseases[J]. Rev Bras Reumatol, 2010, 50(1): 67-80.
24. 　Riachy R, Vandewalle B, Moerman E, et al. 1, 25-Dihydroxyvitamin D3 protects human pancreatic islets against cytokine-induced apoptosis via down-regulation of the Fas receptor[J]. Apoptosis, 2006, 11(2): 151-159.
25. 　沈字玲, 张能, 余华荣. 1, 25-二羟维生素D_3对1型糖尿病预防效果观察[J]. 四川生理科学杂志, 2006, 28(1): 26-28.
26. 　McGill AT, Stewart JM, Lithander FE, et al. Relationships of low serum vitamin D3 with anthropometry and markers of the metabolic syndrome and diabetes in overweight and obesity[J]. Nutr J, 2008, 7(1): 4.
27. 　Alfonso B, Liao E, Busta A, et al. Vitamin D in diabetes mellitus-a new field of knowledge poised for D-velopment[J]. Diabetes Metab Res Rev, 2009, 25(5): 417-419.
28. 　Kayaniyil S, Vieth R, Retnakaran R, et al. Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes[J]. Diabetes Care, 2010, 33(6): 1379- 1381.
29. 　Maghbooli Z, Hossein-Nezhad A, Karimi F, et al. Correlation between vitamin D3 deficiency and insulin resistance in pregnancy[J]. Diabetes Metab Res Rev, 2008, 24(1): 27-32.
30. 　Selimoglu H, Duran C, Kiyici S, et al. The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome[J]. J Endocrinol Invest, 2010, 33(4): 234-238.
31. 　Pittas AG, Lau J, Hu FB, et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis[J]. J Clin Endocrinol Metab, 2007, 92(6): 2017-2029.
32. 　Fujita T, Palmieri GM. Calcium paradox disease: calcium deficiency prompting secondary hyperparathyroidism and cellular calcium overload[J]. J Bone Miner Metab, 2000, 18(3): 109-125.
33. 　Kamycheva E, Jorde R, Figenschau Y, et al. Insulin sensitivity in subjects with secondary hyperparathyroidism and the effect of a low serum 25-hydroxyvitamin D level on insulin sensitivity[J]. J Endocrinol Invest, 2007, 30(2): 126-132.
34. 　Need AG, O’Loughlin PD, Horowitz M, et al. Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women[J]. Clin Endocrinol (Oxf), 2005, 62(6): 738-741.
35. 　Bonakdaran S, Varasteh AR. Correlation between serum 25 hydroxy vitamin D3 and laboratory risk markers of cardiovascular diseases in type 2 diabetic patients[J]. Saudi Med J, 2009, 30(4): 509-514.
36. 　Hashemipour S, Larijani B, Adibi H, et al. The status of biochemical parameters in varying degrees of vitamin D deficiency[J]. J Bone Miner Metab, 2006, 24(3): 213-218.
37. 　Guo SW, Magnuson VL, Schiller JJ, et al. Meta-analysis of vitamin D receptor polymorphisms and type 1 diabetes: a HuGE review of genetic association studies[J]. Am J Epidemiol, 2006, 164(8): 711-724.
38. 　Bid HK, Konwar R, Aggarwal CG, et al. Vitamin D receptor (FokI, BsmI and TaqI) gene polymorphisms and type 2 diabetes mellitus: a North Indian study[J]. Indian J Med Sci, 2009, 63(5): 187-94.
39. 　Palomer X, González-Clemente JM, Blanco-Vaca F, et al. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus[J]. Diabetes Obes Metab, 2008, 10(3): 185-197.

West China Medical Journal

维生素D缺乏与糖尿病

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