Analysis on Clinical Features of AIDS Patients_West China Medical Journal

Authors：

LI Li ,  LIU Gang

Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LIU Gang, Email: huaxi1985lili@yahoo.cn

Keywords：

人类免疫缺陷病毒; 感染; 风湿病症状

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【摘要】　目的　观察人类免疫缺陷病毒（HIV）感染后对人体各个系统的影响，为其诊断和治疗提供经验。　方法　回顾性分析2005年1月—2010年6月于华西医院确诊为HIV感染13例患者的临床表现和相关实验室指标。　结果　 13例HIV感染患者均合并其他感染，以结核病最为常见；除有T淋巴细胞异常外，多数患者可合并出现血液学异常，包括贫血、白细胞和血小板降低；生化异常，包括球蛋白升高、白蛋白降低；HIV感染患者可合并出现风湿病症状和免疫学异常。　结论　 HIV感染患者临床表现复杂多样，可合并出现多种感染和风湿病症状，血液学及免疫学异常也比较常见。
【Abstract】　Objective　 To observe the impact of human immunodeficiency virus (HIV) on each system of human body after its infection, in order to provide experiences for diagnosis and treatment of this disease.　Methods　 The clinical manifestations and related laboratory results of 13 inpatients treated in West China Hospital of Sichuan University from January 2005 to June 2010 were reviewed retrospectively.　Results　 The incidence of infection in these patients was 100% with tuberculosis as the most common infection. Apart from the abnormality of T lymphocytes, most patients had a change of hematology and biochemistry, including anemia, depression of leucocytes and platelets, hyperglobulinemia and hypoproteinemia; HIV-infected patients may also presented with rheumatic manifestations or abnormality in the immune system.　Conclusion　 The clinical manifestations of patients with AIDS are complicated. Many kinds of infections and rheumatic manifestations may merge and the change in hematology and immunology is common.

Citation： LI Li,LIU Gang. Analysis on Clinical Features of AIDS Patients. West China Medical Journal, 2011, 26(6): 874-877. doi: Copy

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7.	谭琳, 谢瑜, 周挚. 艾滋病患者 CD4+细胞计数与外周血细胞计数关系的研究[J]. 临床荟萃, 2009, 24(5): 396-398.
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9.	Russo S, Lopalco L. Is autoimmunity a component of natural immunity to HIV?[J]. Curr HIV Res, 2006, 4(2): 177-190.
10.	Root-Bernstein R, Rallo A. Antigenic complementarity resulting in idiotype-antiidiotype immune complexes: possible contributor to AIDS pathogenesis and autoimmunity[J]. Autoimmunity, 2004, 37(3): 203-210.
11.	Rynes RI. HIV and rheumatologic autoimmune phenomena: imitator or illuminator[J]. Clin Exp Rheumatol, 1990, 8(2): 103-106.
12.	刘德纯. 艾滋病临床病理学[M]. 合肥:安徽科学技术出版社, 2002: 1140-1141.
13.	Kulthanan K, Jiamton S, Omcharoen V, et al. Autoimmune and rheumatic manifestations and antinuclear antibody study in HIV-infected Thai patients[J]. Int J Dermatol, 2002, 41(7): 417-422.
14.	Reveille JD, Williams FM. Infection and musculoskeletal conditions: Rheumatologic complications of HIV infection[J]. Best Pract Res Clin Rheumatol, 2006, 20(6): 1159-1179.
15.	Cuellar ML. HIV infection-associated inflammatory musculoskeletal disorders[J]. Rheum Dis Clin North Am, 1998, 24(2): 403-421.
16.	Kaye BR. Rheumatologic manifestations of infection with human immunodeficiency virus (HIV)[J]. Ann Intern Med, 1989, 111(2): 158-167.

1. 　刘春云, 成培金, 廖远, 等. 2005-2008年兴文县HIV-AIDS流行病学分析[J]. 预防医学情报杂志, 2009, 25(8): 677-678.
2. 　王少俭, 李胜洋. 122例艾滋病机会性感染临床分析[J]. 河南预防医学杂志, 2010, 21(2): 93-96.
3. 　张兴权, 范江. 艾滋病毒感染与艾滋病[M]. 北京:人民卫生出版社, 1999: 173-230.
4. 　Olayemi E, Awodu OA, Bazuaye GN. Autoimmune hemolytic anemia in HIV-infected patients: a hospital based study[J]. Ann Afr Med, 2008, 7(2): 72-76.
5. 　潘光合, 谭勇, 吴文旺, 等. 出入境人群HIVg感染者/AIDS患者血清生化指标分析[J]. 旅行医学科学, 2009, 15(2): 4-7.
6. 　张自华, 张群智, 孔山. 129例HIV感染者血清蛋白分析[J]. 海南医学, 2010, 21(3): 93-94.
7. 　谭琳, 谢瑜, 周挚. 艾滋病患者 CD4+细胞计数与外周血细胞计数关系的研究[J]. 临床荟萃, 2009, 24(5): 396-398.
8. 　Sarcletti M, Bitterlich W, Fuchs D, et al. Is the poorer rate of survival among patients with human immunodeficiency virus infection and anemia linked to immune activation?[J]. J Infect Dis, 2002, 186(1): 141-142.
9. 　Russo S, Lopalco L. Is autoimmunity a component of natural immunity to HIV?[J]. Curr HIV Res, 2006, 4(2): 177-190.
10. 　Root-Bernstein R, Rallo A. Antigenic complementarity resulting in idiotype-antiidiotype immune complexes: possible contributor to AIDS pathogenesis and autoimmunity[J]. Autoimmunity, 2004, 37(3): 203-210.
11. 　Rynes RI. HIV and rheumatologic autoimmune phenomena: imitator or illuminator[J]. Clin Exp Rheumatol, 1990, 8(2): 103-106.
12. 　刘德纯. 艾滋病临床病理学[M]. 合肥:安徽科学技术出版社, 2002: 1140-1141.
13. 　Kulthanan K, Jiamton S, Omcharoen V, et al. Autoimmune and rheumatic manifestations and antinuclear antibody study in HIV-infected Thai patients[J]. Int J Dermatol, 2002, 41(7): 417-422.
14. 　Reveille JD, Williams FM. Infection and musculoskeletal conditions: Rheumatologic complications of HIV infection[J]. Best Pract Res Clin Rheumatol, 2006, 20(6): 1159-1179.
15. 　Cuellar ML. HIV infection-associated inflammatory musculoskeletal disorders[J]. Rheum Dis Clin North Am, 1998, 24(2): 403-421.
16. 　Kaye BR. Rheumatologic manifestations of infection with human immunodeficiency virus (HIV)[J]. Ann Intern Med, 1989, 111(2): 158-167.

West China Medical Journal

Analysis on Clinical Features of AIDS Patients

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