An Analysis of the Relationship between Pulse Pressure, Pulse Pressure Index and Hyperuricemia in Middle-aged and Aged Residents in Chengdu_West China Medical Journal

Authors：

WU Kai ^1,2 , WANG Si ¹ ,  CHEN Xiaoping ¹ , GAO Yin ² , CHEN Xiaoni ¹ , ZHANG Xin ¹ , HE Sen ¹ , LIU Kai ¹ , LUuml ¹

1. Department of Cardiology, West China Hospital, Sichuan University, Chengdu,Sichuan 610041, P. R. China; 2. Department of Cardiology, 903 Hospital, Jiangyou, Sichuan 621007, P. R. China;

Corresponding author：

CHEN Xiaoping, Email: sprite0944@163.com

Keywords：

脉压; 脉压指数; 收缩压; 舒张压; 尿酸; 高尿酸血症

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【摘要】　目的　分析成都地区中老年居民脉压（pulse pressure， PP）及脉压指数（pulse presure index，PPI）与高尿酸血症（hyperuricemia，HUA）的关系。　方法　利用2007年5月代谢综合征研究调查资料（共1 061人），依据PP[≤60 mm Hg（1 mm Hg=0.133 kPa）、 gt;60 mm Hg]和PPI（≤0.450、 gt;0.450）将人群分为正常组及增高组，分析两组人群尿酸水平及HUA患病率，采用单因素回归及logistic回归分析PP及PPI与HUA关系。　结果　 ①PP/PPI增高组血浆尿酸水平明显高于PP/PPI正常组，差异有统计学意义（P=0.000）。②PP/PPI增高组HUA患病率明显高于PP/PPI正常组，差异有统计学意义（P=0.026、0.027）。③单因素回归和logistic回归分析皆提示PP及PPI与HUA呈正相关。　结论　成都地区PP及PPI与血浆尿酸水平关系密切，PP/PPI增高可能是HUA的危险因素。
【Abstract】　Objective　 To evaluate the relationship between pulse pressure (PP), pulse pressure index (PPI) and hyperuricemia (HUA) among middle-aged and aged residents in Chengdu.　Methods　 Based on the level of PP [≤60 mm Hg (1 mm Hg=0.133 kPa), gt;60 mm Hg] and PPI (≤0.450, gt;0.450), We divided the 1 061 middle-aged or aged people into normal PP/PPI group and augmented PP/PPI group. All patients came from the survey for metabolic syndrome study in May 2007. We analyzed the distribution of serum uric acid (UA) and HUA, and analyzed the relationship between PP, PPI and HUA by using single-factor and logistic regression analysis.　Results　 The index of UA in the augmented PP/PPI groups was higher than that in the normal groups with a significant difference (P=0.000). The prevalence of HUA in the augmented PP/PPI groups was statistically higher than that in the normal groups (P=0.026, 0.027). Single-factor and logistic regression analysis showed that PP and PPI were both positively correlated to HUA.　Conclusion　 The abnormalities of PP and PPI are closely related to metabolism disorder in Chengdu, and high level of PP or PPI is probably risk factors for HUA.

Citation： WU Kai,WANG Si,CHEN Xiaoping,GAO Yin,CHEN Xiaoni,ZHANG Xin,HE Sen,LIU Kai,LUuml,Zhengbing. An Analysis of the Relationship between Pulse Pressure, Pulse Pressure Index and Hyperuricemia in Middle-aged and Aged Residents in Chengdu. West China Medical Journal, 2011, 26(7): 1010-1013. doi: Copy

1.	Benetos A, Thomas F, Joly L, et al. Pulse pressure amplification: A mechanical biomarker of cardiovascular risk[J]. JACC, 2010, 55(10): 1032-1037.
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5.	Madhavn S, Qoi WL, Cohen H, et al. Relation of pulse and blood pressure reduction to the incidence of myocardial infarction[J]. Hypertension, 1994, 23(3): 395-401.
6.	柏淑禹, 郑闻, 陈茂华, 等. 原发性高血压患者微量白蛋白尿与心脏结构改变的关系[J]. 实用老年医学, 2005, 19 (1): 44.
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10.	Antonini-Canterin F, Carerj S, di Bello V, et al. Arterial stiffness and ventricular stiffness: a couple of diseases or a coupling disease? A review from the cardiologist’s point of view [J]. Eur J Echocardiogr, 2009, 10(1): 36-43.
11.	Chantler PD, Lakatta EG, Najjar SS. Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise[J]. J Appl Physiol, 2008, 105(4): 1342-1351.
12.	Ryan SM, Waack BJ, Weno BL, et al. Increases in pulse pressure impair acetylcholine-induced vascular relaxation[J]. Am J Physiol, 1995, 268(Pt 2): 359-363.
13.	王静, 苑杰, 胡万宁, 等. 3 850名老年人脉压指数水平分析[J]. 中国老年学杂志, 2005, 25(1): 15-16.
14.	Cruickshank K, Riste L, Anderson SG, et al. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?[J]. Circulation, 2002, 106(16): 2085-2090.
15.	Wang X, Keith JC Jr, Struthers AD, et al. Assessment of arterial stiffness, a translational medicine biomarker system for evaluation of vascular risk[J]. Cardiovasc Ther, 2008, 26(3): 214-223.

1. 　Benetos A, Thomas F, Joly L, et al. Pulse pressure amplification: A mechanical biomarker of cardiovascular risk[J]. JACC, 2010, 55(10): 1032-1037.
2. 　Franklin SS, Khan SA, Wong ND, et al. Is pulse pressure usful in predicting risk for coronary heart disease? The Framingham Heart Study[J]. Circulation, 1999, 100(4): 354-360.
3. 　周北凡, 刘小清, 武阳丰, 等. 我国中年人群脉压对于心血管病事件发病的预测价值[J].中华心血管病杂志, 2002, 30(11): 687-691.
4. 　杨鹏麟, 徐定修, 张素勤. 脉压指数评价血管硬化的可行性探讨[J]. 中华心血管病杂志, 2002, 30(6): 334-337.
5. 　Madhavn S, Qoi WL, Cohen H, et al. Relation of pulse and blood pressure reduction to the incidence of myocardial infarction[J]. Hypertension, 1994, 23(3): 395-401.
6. 　柏淑禹, 郑闻, 陈茂华, 等. 原发性高血压患者微量白蛋白尿与心脏结构改变的关系[J]. 实用老年医学, 2005, 19 (1): 44.
7. 　翟丽华, 董少红, 李光展, 等. 老年高血压动态脉压与心血管重塑的相关性研究[J]. 实用老年医学, 2001, 15(2): 78.
8. 　Feig DI, Kang DH, Johnson RJ. Uric acid and cardiovascular risk[J]. N Engl J Med, 2008, 359(17): 1811-1821.
9. 　Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited [J]. Arterioscler Thromb Vasc Biol, 2004, 24(5): 816-823.
10. 　Antonini-Canterin F, Carerj S, di Bello V, et al. Arterial stiffness and ventricular stiffness: a couple of diseases or a coupling disease? A review from the cardiologist’s point of view [J]. Eur J Echocardiogr, 2009, 10(1): 36-43.
11. 　Chantler PD, Lakatta EG, Najjar SS. Arterial-ventricular coupling: mechanistic insights into cardiovascular performance at rest and during exercise[J]. J Appl Physiol, 2008, 105(4): 1342-1351.
12. 　Ryan SM, Waack BJ, Weno BL, et al. Increases in pulse pressure impair acetylcholine-induced vascular relaxation[J]. Am J Physiol, 1995, 268(Pt 2): 359-363.
13. 　王静, 苑杰, 胡万宁, 等. 3 850名老年人脉压指数水平分析[J]. 中国老年学杂志, 2005, 25(1): 15-16.
14. 　Cruickshank K, Riste L, Anderson SG, et al. Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function?[J]. Circulation, 2002, 106(16): 2085-2090.
15. 　Wang X, Keith JC Jr, Struthers AD, et al. Assessment of arterial stiffness, a translational medicine biomarker system for evaluation of vascular risk[J]. Cardiovasc Ther, 2008, 26(3): 214-223.

West China Medical Journal

An Analysis of the Relationship between Pulse Pressure, Pulse Pressure Index and Hyperuricemia in Middle-aged and Aged Residents in Chengdu

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