【摘要】 目的 了解原发性开角型青光眼患者用2%盐酸卡替洛尔滴眼液后的眼压及眼脉动幅度变化特征。 方法 选取2009年1－12月确诊为原发性开角型青光眼患者19例32只眼。给予2%盐酸卡替洛尔滴眼液点眼1周，2次/d。用动态轮廓眼压计测量患者用药前后的眼压、眼脉动幅度，同时测量患者的血压及心率。比较用药前后眼压及眼脉动幅度的变化，并用SPSS 14.0统计学软件对用药前后的眼压及眼脉动幅度数据进行配对t检验及Pearson相关性分析。 结果 患者用药前后眼压分别为（22.76±4.29）、（17.79±2.93） mm Hg（1 mm Hg=0.133 kPa），眼脉动幅度分别为（3.47±1.00）、（2.63±0.86） mm Hg。患者的眼压及眼脉动幅度用药后较用药前明显降低，差异有统计学意义（P lt;0.01），用药前后的眼压与眼脉动幅度之间存在正相关关系（r=0.444， 0.364；P=0.011， P=0.040）。眼压及眼脉动幅度与患者的血压及心率均无相关性。 结论 原发性开角型青光眼患者用2%盐酸卡替洛尔滴眼液后眼压及眼脉动幅度均有显著降低，眼压与眼脉动幅度有正相关性。眼压及眼脉动幅度与血压及心率无相关关系。
【Abstract】 Objective To investigate the variations of intraocular pressure (IOP) and ocular pulse amplitude (OPA) in patients with primary open-angle glaucoma after 2% carteolol hydrochloride was applied. Methods Thirty-two eyes of 19 patients with primary open-angle glaucoma diagnosed between January and December 2009 were chosen to be the study subjects. The patients received 2% cartelol hydrochloride eye drops twice a day for one week. IOP and OPA before and after using cartelol were measured by dynamic contour tonometry (DCT). Blood pressure and heart rate were detected at the same time. The variations of IOP and OPA were analyzed by SPSS 14.0. t test and Pearson correlation analysis were applied. Results The mean IOP and OPA before and after using cartelol were respectively (22.76±4.29) mm Hg (1 mm Hg=0.133 kPa) vs. (17.79±2.93) mm Hg, and (3.47±1.00) mm Hg vs. (2.63±0.86) mm Hg. Both of them decreased significantly after the use of cartelol (P＜0.01). OPA was obviously correlated with IOP both before and after using cartelol (r=0.444, 0.364; P=0.011, 0.040). OPA and IOP had no correlation with blood pressure and heart rate. Conclusions OPA and IOP decreases signifficantly after the use of 2% carteolol hydrochloride. OPA is signifficantly correlated with IOP. OPA and IOP have no correlation with blood pressure and heart rate.
Citation： LI Peifeng,CHENG Xukang,YU Feng,CHEN Heping. Influences of Carteolol Hydrochloride on Intraocular Pressure and Ocular Pulse Amplitude in Patients with Primary Open-angle Glaucoma. West China Medical Journal, 2011, 26(8): 1197-1199. doi: Copy