Research on the Correlation between Serum Level of Cystatin C and Acute Myocardial Infarction in Elderly Patients_West China Medical Journal

Authors：

HAN Xing ¹ ,  WU Jinhui ² , LEI Xiaoyan ¹ , ZHANG Shaomin ² , ZHAO Yanping ²

1. Department of Emergency, the 4th Hospital of Sichuan Province, Chengdu, Sichuan 610021, P. R. China; 2. Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

WU Jinhui, Email: hanxing72@yahoo.com.cn

Keywords：

胱抑素C; 急性心肌梗死; 老年

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【摘要】　目的　观察70岁以上老年心肌梗死急性期血清胱抑素C（cystatin C，CysC）水平，探讨急性心肌梗死后CysC水平变化的意义。　方法　顺序入选2010年7月-2011年7月期间70岁以上急性心肌梗死患者58例及正常对照58例。入选对象均经冠状动脉造影检查确诊或排除诊断，记录急性心肌梗死患者梗死部位和梗死相关血管，并计算Gensini积分。所有入选对象采血，使用乳胶增强免疫透射比浊法测定急性期血清CysC水平。　结果　心肌梗死急性期，血清CysC水平低于正常对照组（P lt;0.05）；不同冠状动脉病变评分与血清CysC水平呈负相关，Gensini积分越高，血清CysC水平越低。　结论　血清CysC与冠心病关系密切。检测CysC，为冠心病的风险预测、老年患者危险分层和治疗提供一条新的线索和途径。

Citation： HAN Xing,WU Jinhui,LEI Xiaoyan,ZHANG Shaomin,ZHAO Yanping. Research on the Correlation between Serum Level of Cystatin C and Acute Myocardial Infarction in Elderly Patients. West China Medical Journal, 2011, 26(9): 1309-1311. doi: Copy

1.	Grubb A, Löfberg H. Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis[J]. Proc Natl Acad Sci USA, 1982, 79(9): 3024-3027.
2.	Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction[J]. Circulation, 2007, 116(22): 2634-2653.
3.	Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J]. Am J Cardiol, 1983, 51(3): 606-606.
4.	Shi GP, Sukhova GK, Grubb A, et al. Cystatin c deficiency in human atherosclerosis and aortic aneurysms[J]. J Clin Invest, 1999, 104(9): 1191-1197.
5.	Cheng XW, Kuzuya M. Sasaki T, et al. Increased expression of elastolytic cysteine proteasesa,cathepsins S and K, in the neointima of balloon-injured rat carotid arteries[J]. Am J Pathol, 2004, 164(1): 243-251.
6.	Luc G, Bard JM, Lesueur C, et al. Plasma cystatin-C and development of coronary heart disease: the PRIME Study[J]. Atherosclersis, 2006, 85(2): 375-380.
7.	Koeni W, Twardella D, Brenner H, et al. Plasma concentration of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rat[J]. Clin Chem, 2005, 51 (2): 321-327.
8.	Noto D, Cefalu AB, Barbagallo CM, et al. Cystatin C levels are decreased in acute myocardial infarction: effect of cystatin C G73A gene polymorphism on plasma level[J]. Int J Cardiol, 2005, 101(2): 213-217.
9.	冯建芳, 汪淑荣, 李平, 等. 急性心肌梗死病人血清巯基蛋白酶抑制肽C的变化[J]. 基础医学与临床, 1995, 15(4): 45-47.
10.	Sukhova GK, Wang B, Libby P, et al. Cystatin C deficiency increase elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice[J]. Circ Res, 2005, 96(3): 368-375.
11.	Eriksson P, DeguchiH, Samnegard A, et al. Human evidence that the cystatin C gene is imp licated in focal progression of coronary artery disease[J]. Arterioscler Thromb Vasc Biol, 2004, 24(3): 551-557.
12.	Kilic T, Oner G, Ural E, et al. Comparison of the long-term prognostic value of cystatin C to other indicators of renal function, markers of inflammation and systolic dysfunction among patients with acute coronary syndrome[J]. Atherosclerosis, 2009, 207(2): 552-558.
13.	Ichimoto E, Jo K, Kobayashi Y, et al. Prognostic significance of cystatin C in patients with ST-elevation myocardial infarction[J]. Circ J, 2009, 73(9): 1669-1673.
14.	Frendéus KH, Wallin H, Janciauskiene S, et al. Macrophage responses to interferon-gamma are dependent on cystatin C levels[J]. Int J Biochem Cell Biol, 2009, 41(11): 2262-2269.
15.	Naruse H, Ishii J, Kawai T, et al. Cystatin C in acute heart failure without advanced renal impairment[J]. Am J Med, 2009, 122(6): 566-573.
16.	García Acuna JM, González-Babarro E, Grigorian Shamagian L, et al. Cystatin C provides more information than other renal function parameters for stratifying risk in patients with acute coronary syndrome[J]. Rev Esp Cardiol, 2009, 62(5): 510-519.

1. 　Grubb A, Löfberg H. Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis[J]. Proc Natl Acad Sci USA, 1982, 79(9): 3024-3027.
2. 　Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction[J]. Circulation, 2007, 116(22): 2634-2653.
3. 　Gensini GG.A more meaningful scoring system for determining the severity of coronary heart disease[J]. Am J Cardiol, 1983, 51(3): 606-606.
4. 　Shi GP, Sukhova GK, Grubb A, et al. Cystatin c deficiency in human atherosclerosis and aortic aneurysms[J]. J Clin Invest, 1999, 104(9): 1191-1197.
5. 　Cheng XW, Kuzuya M. Sasaki T, et al. Increased expression of elastolytic cysteine proteasesa,cathepsins S and K, in the neointima of balloon-injured rat carotid arteries[J]. Am J Pathol, 2004, 164(1): 243-251.
6. 　Luc G, Bard JM, Lesueur C, et al. Plasma cystatin-C and development of coronary heart disease: the PRIME Study[J]. Atherosclersis, 2006, 85(2): 375-380.
7. 　Koeni W, Twardella D, Brenner H, et al. Plasma concentration of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rat[J]. Clin Chem, 2005, 51 (2): 321-327.
8. 　Noto D, Cefalu AB, Barbagallo CM, et al. Cystatin C levels are decreased in acute myocardial infarction: effect of cystatin C G73A gene polymorphism on plasma level[J]. Int J Cardiol, 2005, 101(2): 213-217.
9. 　冯建芳, 汪淑荣, 李平, 等. 急性心肌梗死病人血清巯基蛋白酶抑制肽C的变化[J]. 基础医学与临床, 1995, 15(4): 45-47.
10. 　Sukhova GK, Wang B, Libby P, et al. Cystatin C deficiency increase elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice[J]. Circ Res, 2005, 96(3): 368-375.
11. 　Eriksson P, DeguchiH, Samnegard A, et al. Human evidence that the cystatin C gene is imp licated in focal progression of coronary artery disease[J]. Arterioscler Thromb Vasc Biol, 2004, 24(3): 551-557.
12. 　Kilic T, Oner G, Ural E, et al. Comparison of the long-term prognostic value of cystatin C to other indicators of renal function, markers of inflammation and systolic dysfunction among patients with acute coronary syndrome[J]. Atherosclerosis, 2009, 207(2): 552-558.
13. 　Ichimoto E, Jo K, Kobayashi Y, et al. Prognostic significance of cystatin C in patients with ST-elevation myocardial infarction[J]. Circ J, 2009, 73(9): 1669-1673.
14. 　Frendéus KH, Wallin H, Janciauskiene S, et al. Macrophage responses to interferon-gamma are dependent on cystatin C levels[J]. Int J Biochem Cell Biol, 2009, 41(11): 2262-2269.
15. 　Naruse H, Ishii J, Kawai T, et al. Cystatin C in acute heart failure without advanced renal impairment[J]. Am J Med, 2009, 122(6): 566-573.
16. 　García Acuna JM, González-Babarro E, Grigorian Shamagian L, et al. Cystatin C provides more information than other renal function parameters for stratifying risk in patients with acute coronary syndrome[J]. Rev Esp Cardiol, 2009, 62(5): 510-519.

West China Medical Journal

Research on the Correlation between Serum Level of Cystatin C and Acute Myocardial Infarction in Elderly Patients

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