成纤维碱性细胞生长因子与高血压病的研究进展_West China Medical Journal

Authors：

张绍敏 ,  吴锦晖

Corresponding author：

吴锦晖, Email: zhangshm315@163.com

Keywords：

高血压病; 成纤维碱性细胞生长因子

Video：

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【摘要】　成纤维碱性细胞生长因子在高血压病的发生发展中起着重要作用，其机制可能与促进血管平滑肌细胞增殖、促进血压所致的内皮细胞增殖、促进新生血管生成、参与血管重构和促进成纤维细胞迁移等相关。成纤维碱性细胞生长因子与高血压病的关系，还有待进一步的实验依据，这将为开发新型降压药物提供更多证据。

Citation： 张绍敏,吴锦晖. 成纤维碱性细胞生长因子与高血压病的研究进展. West China Medical Journal, 2011, 26(9): 1424-1427. doi: Copy

1.	Li GH, Yang GJ. Inhibitory effect of antisense basic fibroblast growth factor oligonucleotides on proliferation of cultured aortic smooth muscle cells induced by angiotensin Ⅱ in SHR rats[J]. Zhongguo Yao Li Xue Bao, 1998, 19(2): 132-135.
2.	Wang Z, Rao PJ, Shillcutt SD, et al.Angiotensin Ⅱ induces proliferation of human cerebral artery smooth muscle cells through a basic fibroblast growth factor (bFGF) dependent mechanism[J]. Neurosci Lett, 2005, 373(1): 38-41.
3.	李国红, 丁金凤, 张琪, 等. 血管紧张素Ⅱ促高血压大鼠血管平滑肌细胞增殖机制的研究[J]. 中华心血管病杂志, 1995, 23(6): 449-452.
4.	Skaletz-Rorowski A, Eschert H, Leng J, et al. PKC δ-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells[J]. Cardiovascular Research,2005, 67(1): 142-150.
5.	Michiels C, de Leener F, Arnould T, et al. Hypoxia stimulates human endothelial cells to release smooth muscle cell mitogens: role of prostaglandins and bFGF[J]. Exp Cell Res, 1994, 213(1): 43-54.
6.	谷庆阳, 王德文, 彭瑞云, 等. MAPK信号转导途径参与bFGF抑制辐射诱导的脐静脉内皮细胞凋亡的作用[J]. 中华放射医学与防护杂志, 2003, 23(4): 244-246.
7.	Sieber CC, Sumanovski LT, Stumm M, et al. In vivo angiogenesis in normal and portal hypertensive rats: role of basic fibroblast growth factor and nitric oxide[J]. J Hepatol, 2001, 34(5): 644-650.
8.	Srivastava S, Terjung RL,Yang HT, et al. Basic fibroblast growth factor increases collateral blood flow in spontaneously hypertensive rats[J].Am J Physiol Heart Circ Physiol, 2003, 285(3): H1190- H1197.
9.	Arcot SS, Fagerland JA, Lipke DW, et al. Basic fibroblast growth factor alterations during development of monocrotaline-induced pulmonary hypertension in rats[J].Growth Factors, 1995, 12(2): 121-130.
10.	陈文彬, 颜浩. bFGF mRNA在慢性低氧性肺动脉高压大鼠肺组织中的表达及分布[J]. 华西医科大学学报, 1999, 30(1): 1-4.
11.	Lee EU, Xia Ying, Kim WS, et al. Hypoxia-enhanced wound-healing function of adipose-derived stem cells: Increase in stem cell proliferation and up-regulation of VEGF and bFGF[J]. Wound Repair & Regeneration, 2009, 17(4): 540-547.
12.	Xie JL, Bian HN, Qi SH, et al. Basic fibroblast growth factor (bFGF) alleviates the scar of the rabbit ear model in wound healing[J]. Wound Repair Regen, 2008, 16(4): 576-581.
13.	石丹, 梁晓萍, 梁海南. 血清碱性成纤维细胞生长因子水平与原发性高血压关系初探[J]. 岭南心血管病杂志, 2002, 8(5): 336-337.
14.	Satoh C, Fukuda N, Hu WY, et al. Role of endogenous angiotensin Ⅱ in the increased expression of growth factors in vascular smooth muscle cells from spontaneously hypertensive rats[J]. J Cardiovasc Pharmacol, 2001, 37(1): 108-118.
15.	Suzuki T, Akasaka Y, Namiki A, et al. Basic fibroblast growth factor inhibits ventricular remodeling in Dahl salt-sensitive hypertensive rats[J]. J Hypertens, 2008, 26(12): 2436-2444.
16.	He ZY, Feng B, Yang SL, et al. Intracardiac basic fibroblast growth factor and transforming growth factor-beta 1 mRNA and their proteins expression level in patients with pressure or volume-overload right or left ventricular hypertrophy[J]. Acta Cardiologica, 2005, 60(1): 21-25.
17.	Kurz C, Hefler L, Zeisler H, et al. Maternal basic fibroblast growth factor serum levels are associated with pregnancy-induced hypertension[J]. J Soc Gynecol Investig, 2001, 8(1): 24-26.

1. 　Li GH, Yang GJ. Inhibitory effect of antisense basic fibroblast growth factor oligonucleotides on proliferation of cultured aortic smooth muscle cells induced by angiotensin Ⅱ in SHR rats[J]. Zhongguo Yao Li Xue Bao, 1998, 19(2): 132-135.
2. 　Wang Z, Rao PJ, Shillcutt SD, et al.Angiotensin Ⅱ induces proliferation of human cerebral artery smooth muscle cells through a basic fibroblast growth factor (bFGF) dependent mechanism[J]. Neurosci Lett, 2005, 373(1): 38-41.
3. 　李国红, 丁金凤, 张琪, 等. 血管紧张素Ⅱ促高血压大鼠血管平滑肌细胞增殖机制的研究[J]. 中华心血管病杂志, 1995, 23(6): 449-452.
4. 　Skaletz-Rorowski A, Eschert H, Leng J, et al. PKC δ-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells[J]. Cardiovascular Research,2005, 67(1): 142-150.
5. 　Michiels C, de Leener F, Arnould T, et al. Hypoxia stimulates human endothelial cells to release smooth muscle cell mitogens: role of prostaglandins and bFGF[J]. Exp Cell Res, 1994, 213(1): 43-54.
6. 　谷庆阳, 王德文, 彭瑞云, 等. MAPK信号转导途径参与bFGF抑制辐射诱导的脐静脉内皮细胞凋亡的作用[J]. 中华放射医学与防护杂志, 2003, 23(4): 244-246.
7. 　Sieber CC, Sumanovski LT, Stumm M, et al. In vivo angiogenesis in normal and portal hypertensive rats: role of basic fibroblast growth factor and nitric oxide[J]. J Hepatol, 2001, 34(5): 644-650.
8. 　Srivastava S, Terjung RL,Yang HT, et al. Basic fibroblast growth factor increases collateral blood flow in spontaneously hypertensive rats[J].Am J Physiol Heart Circ Physiol, 2003, 285(3): H1190- H1197.
9. 　Arcot SS, Fagerland JA, Lipke DW, et al. Basic fibroblast growth factor alterations during development of monocrotaline-induced pulmonary hypertension in rats[J].Growth Factors, 1995, 12(2): 121-130.
10. 　陈文彬, 颜浩. bFGF mRNA在慢性低氧性肺动脉高压大鼠肺组织中的表达及分布[J]. 华西医科大学学报, 1999, 30(1): 1-4.
11. 　Lee EU, Xia Ying, Kim WS, et al. Hypoxia-enhanced wound-healing function of adipose-derived stem cells: Increase in stem cell proliferation and up-regulation of VEGF and bFGF[J]. Wound Repair & Regeneration, 2009, 17(4): 540-547.
12. 　Xie JL, Bian HN, Qi SH, et al. Basic fibroblast growth factor (bFGF) alleviates the scar of the rabbit ear model in wound healing[J]. Wound Repair Regen, 2008, 16(4): 576-581.
13. 　石丹, 梁晓萍, 梁海南. 血清碱性成纤维细胞生长因子水平与原发性高血压关系初探[J]. 岭南心血管病杂志, 2002, 8(5): 336-337.
14. 　Satoh C, Fukuda N, Hu WY, et al. Role of endogenous angiotensin Ⅱ in the increased expression of growth factors in vascular smooth muscle cells from spontaneously hypertensive rats[J]. J Cardiovasc Pharmacol, 2001, 37(1): 108-118.
15. 　Suzuki T, Akasaka Y, Namiki A, et al. Basic fibroblast growth factor inhibits ventricular remodeling in Dahl salt-sensitive hypertensive rats[J]. J Hypertens, 2008, 26(12): 2436-2444.
16. 　He ZY, Feng B, Yang SL, et al. Intracardiac basic fibroblast growth factor and transforming growth factor-beta 1 mRNA and their proteins expression level in patients with pressure or volume-overload right or left ventricular hypertrophy[J]. Acta Cardiologica, 2005, 60(1): 21-25.
17. 　Kurz C, Hefler L, Zeisler H, et al. Maternal basic fibroblast growth factor serum levels are associated with pregnancy-induced hypertension[J]. J Soc Gynecol Investig, 2001, 8(1): 24-26.

West China Medical Journal

成纤维碱性细胞生长因子与高血压病的研究进展

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