【摘要】 宫颈癌的传统治疗方式是根治性手术和放射治疗。以往根据宫颈癌的演变过程，浸润癌的高发年龄为50~55岁，且85%以上是鳞状细胞癌，对放射治疗敏感，放射治疗可达到根治的效果。但近年来，宫颈癌发病有明显年轻化趋势，与其他年龄组比较，年轻宫颈癌患者具有显著不同的临床和病理特征，如非鳞癌比例高、淋巴结转移率高和局部临床期别晚等特点。对于这类患者，若单纯手术或放射治疗，不仅5年生存率低，而且术后易复发，放射治疗者会严重影响其卵巢和阴道功能。为了提高局部晚期宫颈癌患者的生存率，减少复发，必须打破宫颈癌的传统治疗模式。如今，随着化学疗法药物的开发利用和疗效的提高，新辅助化学疗法已成为局部晚期宫颈癌患者综合治疗中的重要组成部分，化学疗法后首选手术，正成为治疗中青年宫颈癌患者的发展趁势。
Citation： 龚琳,彭芝兰. 新辅助化学疗法在局部晚期宫颈癌中的研究进展. West China Medical Journal, 2011, 26(9): 1432-1436. doi: Copy
| 1. | 王泽华. 重视和规范宫颈癌的新辅助化疗[J]. 华中医学杂志, 2007, 31 (6): 423-424. |
| 2. | Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium[J]. Int J Gynaecol Obstet, 2009, 105(2): 103-104. |
| 3. | Timotheadou E, Gore ME. Neoadjuvant chemotherapy for locally advanced cervical cancer[J]. Eur J Cancer, 2003, 39(17): 2419-2421. |
| 4. | Tiersten AD, Selleck MJ, Hershman DL, et al. Phase Ⅱ study of topotecan and paclitaxel for persistent, or metastatic cervical cancer[J]. Gynecol Oncol, 2004, 92(2): 635-638. |
| 5. | Eddy G, Bundy B, CreasmanW, et al. Treatment of (bulky)stage Ⅰb cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical surgery and pelvic/para-aortic lymphadenectomy: a phase Ⅲ trial of the gynecologic oncology group[J]. Gynecol Oncol, 2007, 106(2): 362-369. |
| 6. | Han SC, 章青, 陆嘉德. 大肿块ⅠB、ⅡA期及局部晚期宫颈癌的治疗[J]. 中国癌症杂志, 2006, 16(11): 890-895. |
| 7. | Elit L, Fyles AW, Devries MC, et al. Follow-up for women after treatment for cervical cancer: a systematic review[J]. Gynecol Oncol, 2009, 114 (3): 528-535. |
| 8. | Eifel PJ, Winter K, Morris M, et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01[J]. J Clin Oncol, 2004, 22(5): 872-880. |
| 9. | 刘成红, 毛熙光, 伍宗惠. 近10年川南地区宫颈癌临床特点变化趋势分析[J]. 泸州医学院学报, 2008, 31(3): 312-315. |
| 10. | Zhao EF, Bao L, Li C, et al. Changes in epidemiology and clinical characteristics of cervical cancer over the past 50 years[J]. J First Mil Med Univ, 2005, 25(6): 605-609. |
| 11. | Frei E. Clinical cancer research: an embattled species[J]. Cancer, 1982, 50(10): 1979-1992. |
| 12. | Ryu HS, Kang SB, Kim KT, et al. Efficacy of different types of treatment in FIGO stage IB2 cervical cancer in Korea: results of a multicenter retrospective Korean study (KGOG-1005)[J]. Int J Gynecol Cancer, 2007, 17(1): 132-136. |
| 13. | 赵虹, 王晓燕, 邵淑丽, 等. Ⅰb2-Ⅱb期宫颈鳞癌新辅助化疗前后Bcl-2和Bax的表达差异[J]. 山西医科大学学报, 2008, 39(11): 995-997. |
| 14. | Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome C by the mitochondrial channel VDAC[J]. Nature, 1999, 399(6735): 483-487. |
| 15. | 李莉, 李庭芳, 刘开江. 宫颈癌新辅助化疗临床病理、电镜改变及作用机制的初步探讨[J]. 中国妇产科临床杂志, 2005, 9(9): 439-442. |
| 16. | Robati M, Holtz D, Dunton CJ. A review of topotecan in combination chemotherapy for advanced cervical cancer[J]. Ther Clin Risk Manag, 2008, 4(1): 213-218. |
| 17. | Souhami L, Gil RA, Allan SE, et al. A randomized trial of chemotherapy followed by pelvic radiation therapy in stage ⅢB carcinoma of the cervix[J]. J Clin Oncol, 1991, 9(6): 970-977. |
| 18. | 李庆水, 张锡芹, 李大鹏, 等. 子宫颈癌放疗前新辅助化疗的临床研究[J]. 中华妇产科杂志, 2006, 41(2): 83-87. |
| 19. | Tabata T, Takeshima N, Nishida H, et al. A randomized study of primary bleomycin, vincristine, mitomycin and cisplatin (BOMP) chemotherapy followed by radiotherapy versus radiotherapy alone in stage IIIB and IVA squamous cell carcinoma of the cervix[J]. Anticancer Res, 2003, 23(3C): 2885-2890. |
| 20. | Tierney J. Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review andmeta-analysis of individual patient data from 21 randomized trials[J]. Eur J Cancer, 2003, 39 (17): 2470-2486. |
| 21. | Bader HA, Winter R, Moinfar F, et al. Is intraoperative frozen section analysis of pelvic lymph nodes accurate after neoadjuvant chemotherapy in patients with cervical cancer?[J]. Gynecol Oncol, 2006, 103(1): 106-112. |
| 22. | Chun M. Time for global efforts with clinical trials for advanced cervical cancer patients[J]. J Gynecol Oncol, 2009, 20(4): 201-202. |
| 23. | Kumar JV, Doval DC, Rao R, et al. A retrospective study of patients with locally advanced cancer of the cervix treated with neoadjuvant chemotherapy followed by radical surgery[J]. Int J Gynecol Cancer, 2009, 19(3): 417- 422. |
| 24. | 邱俊源, 李莉, 雷筝. 宫颈癌新辅助化疗近期疗效观察[J]. 中华全科医学, 2009, 7(10): 1083-1084. |
| 25. | Term rungruanglert W, Tresukosol D, Vasuratna A, et al. Neoadjuvant gemcitabine and cisplatin followed by radical surgery in (bulky) squamous cell carcinoma of cervix stage IB2[J]. Gynecol Oncol, 2005, 97(2): 576-581. |
| 26. | Benedetti-Panici P, Greggi S, Colombo A, et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study[J]. J Clin Oncol, 2002, 20(1): 179-188. |
| 27. | Cho YH, Kim DY, Kim JH, et al. Comparative study of neoadjuvant chemotherapy before radical hysterectomy and radical surgery alone in stage ⅠB2-ⅡA bulky cervical cancer[J]. J Gynecol Oncol, 2009, 20 (1): 22-27. |
| 28. | Rydzewska L, Tierney J, Vale CL, et al. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer[J]. Cochrane DatabaseSyst Rev, 2010, 20(1): CD007406. |
| 29. | Benedet JL, Pecorelli S, Hacker NF, et al. Staging classifications and clinical practice guidelines of gynaecologic cancer[M/OL]. http://www.figo.org/files/figo-corp/docs/staging_booklet.pdf. |
| 30. | 沈铿, 郎景和. 妇科肿瘤面临的问题和挑战[M]. 北京: 人民卫生出版社, 2002: 237-238. |
| 31. | Tierney JF, Vale C, Symonds P. Concomitant and neoadjuvant chemotherapy for cervical cancer[J]. Clin Oncol (R Coll Radiol), 2008, 20(6): 401-416. |
| 32. | 程晓东, 吕卫国, 叶枫, 等. 局部晚期子宫颈癌新辅助化疗价值的评估[J]. 中华妇产科杂志, 2006, 41(1): 95-98. |
| 33. | Saito T, Takehara M, Lee R, et al. Neoadjuvant chemotherapy with cisplatin, aclacinomycin A, and mitomycin C for cervical adenocarcinoma: a preliminary study[J]. Int J Gynecol Cancer, 2004, 14(3): 483-490. |
| 34. | Loizzi V, Cormio G, Vicino M, et al. Neoadjuvant chemotherapy: an alternative option of treatment for locally advanced cervical cancer[J]. Gynecol Obstet Invest, 2008, 65(2): 96-103. |
| 35. | Hwang YY, Moon H, Cho SH, et al. Ten-year survival of patients with locally advanced, stage ib-iib cervical cancer after neoadjuvant chemotherapy and radical hysterectomy[J]. Gynecol Oncol, 2001, 82(1): 88-93. |
| 36. | Park DC, Suh MJ, Yeo SG. Neoadjuvant paclitaxel and cisplatin in uterine cervical cancer: long-term results[J]. Int J Gynecol Cancer, 2009, 19(5): 943-947. |
| 37. | 王平, 彭芝兰, 张家文, 等. 子宫颈癌新辅助化疗中不同化疗途径的疗效比较[J]. 中华妇产科杂志, 2005, 40(4): 227-230. |
| 38. | Bae JH, Lee SJ, Lee A. Neoadjuvant cisplatin and etoposide followed by radical hysterectomy for stage 1B-2B cervical cancer[J]. Gynecol Oncol, 2008, 111(3): 444-448. |
| 39. | Chen H, Liang C, Zhang L, et al. Clinical efficacy of modified preoperative neoadjuvant chemotherapy in the treatment of locally advanced (stage ⅠB2 to ⅡB) cervical cancer: randomized study[J]. Gynecol Oncol, 2008, 110(3): 308-315. |
| 40. | 曹冬焱, 杨佳欣, 沈铿, 等. 子宫颈癌患者子宫动脉插管与静脉全身化疗两种途径新辅助化疗的效果对比[J]. 中华妇产科杂志, 2008, 43 (12): 888-891. |
| 41. | Ki KD, Song DH, Tong SY, et al. Neoadjuvant chemotherapy in bulky stage ⅠB-ⅡA cervical cancer: results of a quick course with vincristine, bleomycin, and cisplatin[J]. Int J Gynecol Cancer, 2009, 19(1): 50-53. |
| 42. | 潘玫, 李隆玉, 罗兵, 等. 紫杉醇在宫颈癌术前新辅助化疗中的应用[J]. 现代肿瘤医学, 2009, 17(4): 711-712. |
| 43. | Kuzuya K. Chemoradiotherapy for uterine cancer: current status and perspectives[J]. Int J Clin Oncol, 2004, 9(6): 458-470. |
| 44. | Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage ⅠB cervical carcinoma[J]. N Engl J Med, 1999, 340(15): 1154-1161. |
| 45. | Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer[J]. N Engl J Med, 1999, 340(15): 1137-1143. |
| 46. | Peters WA III, Liu PY, Barrett RJ, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early stage cancer of the cervix[J]. J Clin Oncol, 2000, 18(8): 1606-1613. |
| 47. | Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer[J]. N Engl J Med, 1999, 340(15): 1144-1153. |
| 48. | Whitney CW, Sause W, Bundy BN, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study[J]. J Clin Oncol, 1999, 17(5): 1339-1348. |
| 49. | 魏毅利, 方建玲. 局部晚期宫颈癌综合治疗方法探讨[J]. 实用肿瘤学杂志, 2008, 22(3): 224-228. |
| 50. | Duenas-Gonzalez A, Lopez-graniel C, Gonzalez-Enciso A, et al. Concomitant chemoradiation versus neoadjuvant chemotherapy in locally advanced cervical carcinoma: results from two consecutive phase Ⅱ studies[J]. Ann Oncol, 2002, 13(8): 1212-1219. |
| 51. | Gonzalez-Martin A, Gonzalez-Cortijo L, Carballo N, et al. The current role of neoadjuvant chemotherapy in the management of cervical carcinoma[J]. Gynecol Oncol, 2008, 110(3 Suppl 2): S36-S40. |
- 1. 王泽华. 重视和规范宫颈癌的新辅助化疗[J]. 华中医学杂志, 2007, 31 (6): 423-424.
- 2. Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium[J]. Int J Gynaecol Obstet, 2009, 105(2): 103-104.
- 3. Timotheadou E, Gore ME. Neoadjuvant chemotherapy for locally advanced cervical cancer[J]. Eur J Cancer, 2003, 39(17): 2419-2421.
- 4. Tiersten AD, Selleck MJ, Hershman DL, et al. Phase Ⅱ study of topotecan and paclitaxel for persistent, or metastatic cervical cancer[J]. Gynecol Oncol, 2004, 92(2): 635-638.
- 5. Eddy G, Bundy B, CreasmanW, et al. Treatment of (bulky)stage Ⅰb cervical cancer with or without neoadjuvant vincristine and cisplatin prior to radical surgery and pelvic/para-aortic lymphadenectomy: a phase Ⅲ trial of the gynecologic oncology group[J]. Gynecol Oncol, 2007, 106(2): 362-369.
- 6. Han SC, 章青, 陆嘉德. 大肿块ⅠB、ⅡA期及局部晚期宫颈癌的治疗[J]. 中国癌症杂志, 2006, 16(11): 890-895.
- 7. Elit L, Fyles AW, Devries MC, et al. Follow-up for women after treatment for cervical cancer: a systematic review[J]. Gynecol Oncol, 2009, 114 (3): 528-535.
- 8. Eifel PJ, Winter K, Morris M, et al. Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01[J]. J Clin Oncol, 2004, 22(5): 872-880.
- 9. 刘成红, 毛熙光, 伍宗惠. 近10年川南地区宫颈癌临床特点变化趋势分析[J]. 泸州医学院学报, 2008, 31(3): 312-315.
- 10. Zhao EF, Bao L, Li C, et al. Changes in epidemiology and clinical characteristics of cervical cancer over the past 50 years[J]. J First Mil Med Univ, 2005, 25(6): 605-609.
- 11. Frei E. Clinical cancer research: an embattled species[J]. Cancer, 1982, 50(10): 1979-1992.
- 12. Ryu HS, Kang SB, Kim KT, et al. Efficacy of different types of treatment in FIGO stage IB2 cervical cancer in Korea: results of a multicenter retrospective Korean study (KGOG-1005)[J]. Int J Gynecol Cancer, 2007, 17(1): 132-136.
- 13. 赵虹, 王晓燕, 邵淑丽, 等. Ⅰb2-Ⅱb期宫颈鳞癌新辅助化疗前后Bcl-2和Bax的表达差异[J]. 山西医科大学学报, 2008, 39(11): 995-997.
- 14. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome C by the mitochondrial channel VDAC[J]. Nature, 1999, 399(6735): 483-487.
- 15. 李莉, 李庭芳, 刘开江. 宫颈癌新辅助化疗临床病理、电镜改变及作用机制的初步探讨[J]. 中国妇产科临床杂志, 2005, 9(9): 439-442.
- 16. Robati M, Holtz D, Dunton CJ. A review of topotecan in combination chemotherapy for advanced cervical cancer[J]. Ther Clin Risk Manag, 2008, 4(1): 213-218.
- 17. Souhami L, Gil RA, Allan SE, et al. A randomized trial of chemotherapy followed by pelvic radiation therapy in stage ⅢB carcinoma of the cervix[J]. J Clin Oncol, 1991, 9(6): 970-977.
- 18. 李庆水, 张锡芹, 李大鹏, 等. 子宫颈癌放疗前新辅助化疗的临床研究[J]. 中华妇产科杂志, 2006, 41(2): 83-87.
- 19. Tabata T, Takeshima N, Nishida H, et al. A randomized study of primary bleomycin, vincristine, mitomycin and cisplatin (BOMP) chemotherapy followed by radiotherapy versus radiotherapy alone in stage IIIB and IVA squamous cell carcinoma of the cervix[J]. Anticancer Res, 2003, 23(3C): 2885-2890.
- 20. Tierney J. Neoadjuvant chemotherapy for locally advanced cervical cancer: a systematic review andmeta-analysis of individual patient data from 21 randomized trials[J]. Eur J Cancer, 2003, 39 (17): 2470-2486.
- 21. Bader HA, Winter R, Moinfar F, et al. Is intraoperative frozen section analysis of pelvic lymph nodes accurate after neoadjuvant chemotherapy in patients with cervical cancer?[J]. Gynecol Oncol, 2006, 103(1): 106-112.
- 22. Chun M. Time for global efforts with clinical trials for advanced cervical cancer patients[J]. J Gynecol Oncol, 2009, 20(4): 201-202.
- 23. Kumar JV, Doval DC, Rao R, et al. A retrospective study of patients with locally advanced cancer of the cervix treated with neoadjuvant chemotherapy followed by radical surgery[J]. Int J Gynecol Cancer, 2009, 19(3): 417- 422.
- 24. 邱俊源, 李莉, 雷筝. 宫颈癌新辅助化疗近期疗效观察[J]. 中华全科医学, 2009, 7(10): 1083-1084.
- 25. Term rungruanglert W, Tresukosol D, Vasuratna A, et al. Neoadjuvant gemcitabine and cisplatin followed by radical surgery in (bulky) squamous cell carcinoma of cervix stage IB2[J]. Gynecol Oncol, 2005, 97(2): 576-581.
- 26. Benedetti-Panici P, Greggi S, Colombo A, et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study[J]. J Clin Oncol, 2002, 20(1): 179-188.
- 27. Cho YH, Kim DY, Kim JH, et al. Comparative study of neoadjuvant chemotherapy before radical hysterectomy and radical surgery alone in stage ⅠB2-ⅡA bulky cervical cancer[J]. J Gynecol Oncol, 2009, 20 (1): 22-27.
- 28. Rydzewska L, Tierney J, Vale CL, et al. Neoadjuvant chemotherapy plus surgery versus surgery for cervical cancer[J]. Cochrane DatabaseSyst Rev, 2010, 20(1): CD007406.
- 29. Benedet JL, Pecorelli S, Hacker NF, et al. Staging classifications and clinical practice guidelines of gynaecologic cancer[M/OL]. http://www.figo.org/files/figo-corp/docs/staging_booklet.pdf.
- 30. 沈铿, 郎景和. 妇科肿瘤面临的问题和挑战[M]. 北京: 人民卫生出版社, 2002: 237-238.
- 31. Tierney JF, Vale C, Symonds P. Concomitant and neoadjuvant chemotherapy for cervical cancer[J]. Clin Oncol (R Coll Radiol), 2008, 20(6): 401-416.
- 32. 程晓东, 吕卫国, 叶枫, 等. 局部晚期子宫颈癌新辅助化疗价值的评估[J]. 中华妇产科杂志, 2006, 41(1): 95-98.
- 33. Saito T, Takehara M, Lee R, et al. Neoadjuvant chemotherapy with cisplatin, aclacinomycin A, and mitomycin C for cervical adenocarcinoma: a preliminary study[J]. Int J Gynecol Cancer, 2004, 14(3): 483-490.
- 34. Loizzi V, Cormio G, Vicino M, et al. Neoadjuvant chemotherapy: an alternative option of treatment for locally advanced cervical cancer[J]. Gynecol Obstet Invest, 2008, 65(2): 96-103.
- 35. Hwang YY, Moon H, Cho SH, et al. Ten-year survival of patients with locally advanced, stage ib-iib cervical cancer after neoadjuvant chemotherapy and radical hysterectomy[J]. Gynecol Oncol, 2001, 82(1): 88-93.
- 36. Park DC, Suh MJ, Yeo SG. Neoadjuvant paclitaxel and cisplatin in uterine cervical cancer: long-term results[J]. Int J Gynecol Cancer, 2009, 19(5): 943-947.
- 37. 王平, 彭芝兰, 张家文, 等. 子宫颈癌新辅助化疗中不同化疗途径的疗效比较[J]. 中华妇产科杂志, 2005, 40(4): 227-230.
- 38. Bae JH, Lee SJ, Lee A. Neoadjuvant cisplatin and etoposide followed by radical hysterectomy for stage 1B-2B cervical cancer[J]. Gynecol Oncol, 2008, 111(3): 444-448.
- 39. Chen H, Liang C, Zhang L, et al. Clinical efficacy of modified preoperative neoadjuvant chemotherapy in the treatment of locally advanced (stage ⅠB2 to ⅡB) cervical cancer: randomized study[J]. Gynecol Oncol, 2008, 110(3): 308-315.
- 40. 曹冬焱, 杨佳欣, 沈铿, 等. 子宫颈癌患者子宫动脉插管与静脉全身化疗两种途径新辅助化疗的效果对比[J]. 中华妇产科杂志, 2008, 43 (12): 888-891.
- 41. Ki KD, Song DH, Tong SY, et al. Neoadjuvant chemotherapy in bulky stage ⅠB-ⅡA cervical cancer: results of a quick course with vincristine, bleomycin, and cisplatin[J]. Int J Gynecol Cancer, 2009, 19(1): 50-53.
- 42. 潘玫, 李隆玉, 罗兵, 等. 紫杉醇在宫颈癌术前新辅助化疗中的应用[J]. 现代肿瘤医学, 2009, 17(4): 711-712.
- 43. Kuzuya K. Chemoradiotherapy for uterine cancer: current status and perspectives[J]. Int J Clin Oncol, 2004, 9(6): 458-470.
- 44. Keys HM, Bundy BN, Stehman FB, et al. Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage ⅠB cervical carcinoma[J]. N Engl J Med, 1999, 340(15): 1154-1161.
- 45. Morris M, Eifel PJ, Lu J, et al. Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer[J]. N Engl J Med, 1999, 340(15): 1137-1143.
- 46. Peters WA III, Liu PY, Barrett RJ, et al. Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early stage cancer of the cervix[J]. J Clin Oncol, 2000, 18(8): 1606-1613.
- 47. Rose PG, Bundy BN, Watkins EB, et al. Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer[J]. N Engl J Med, 1999, 340(15): 1144-1153.
- 48. Whitney CW, Sause W, Bundy BN, et al. Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study[J]. J Clin Oncol, 1999, 17(5): 1339-1348.
- 49. 魏毅利, 方建玲. 局部晚期宫颈癌综合治疗方法探讨[J]. 实用肿瘤学杂志, 2008, 22(3): 224-228.
- 50. Duenas-Gonzalez A, Lopez-graniel C, Gonzalez-Enciso A, et al. Concomitant chemoradiation versus neoadjuvant chemotherapy in locally advanced cervical carcinoma: results from two consecutive phase Ⅱ studies[J]. Ann Oncol, 2002, 13(8): 1212-1219.
- 51. Gonzalez-Martin A, Gonzalez-Cortijo L, Carballo N, et al. The current role of neoadjuvant chemotherapy in the management of cervical carcinoma[J]. Gynecol Oncol, 2008, 110(3 Suppl 2): S36-S40.