Analysis of the Apoplexy Score and Blood Pressure of the Cerebral Infarction Patients with Recombinant Human Tissue Fibrinolytic Enzyme Original Activators Thrombolysis_West China Medical Journal

Authors：

ZHOU Bifang ,  YANG Rong

Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

YANG Rong, Email: 75031811@qq.com

Keywords：

脑梗死; 重组人组织型纤溶酶原激活剂溶栓; 血压监测; 美国国立卫生研究院卒中量表评分

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【摘要】　目的　对脑梗死患者施行静脉溶栓治疗前后的相关状况和指标进行评价分析。　方法　 2003年1月-2010年11月对神经内科收治的29例脑梗死患者予以静脉溶栓治疗及护理，并就治疗前后各相关时间点血压监测及美国国立卫生研究院卒中量表（National Institute of Health stroke scale，NIHSS）评分情况进行分析。　结果　溶栓前后血压对比显示:溶栓后2 h收缩压相对于溶栓前和溶栓后24 h升高（P lt;0.05）；溶栓前后NIHSS评分差异有统计学意义（P lt;0.05）。　结论　溶栓后患者收缩压出现升高，护理上应该加强血压监控，为临床治疗提供支持。
【Abstract】　Objective　 To investigate the correlated condition and clinical index changes before and after the intravenous thrombolysis of the cerebral infarction patients.　Methods　 The blood pressure and the National Institutes of Health stroke scale (NIHSS) score of 29 cerebral infarction patients with the intravenous thrombolysis treatment between January 2003 and November 2010 were measured and analyzed.　Results　 Two hours after the thrombolysis, the systolic blood pressure significantly increased compared with those before the intravenous thrombolysis and 24 hours after intravenous thrombolysis （P＜0.05）. NIHSS score was significantly decreased after the thrombolysis （P＜0.05）.　Conclusions　 Systolic blood pressure significantly increases after the intravenous thrombolysis. Intensive blood pressure monitoring and controlling may be beneficial to the treatment and prognosis.

Citation： ZHOU Bifang,YANG Rong. Analysis of the Apoplexy Score and Blood Pressure of the Cerebral Infarction Patients with Recombinant Human Tissue Fibrinolytic Enzyme Original Activators Thrombolysis. West China Medical Journal, 2011, 26(10): 1551-1553. doi: Copy

1.	姚敏, 吴江. 急性脑梗死溶栓治疗的研究与展望[J]. 中风与神经疾病杂志, 2007, 24(1): 123-128.
2.	Kenneth B, Søren C,Dormiaty T. et al. Postthrombolysis blood pressure elevation is associated with hemorrhagic transformation[J]. Stroke, 2010, 41(1): 72-77.
3.	Ahmed N, Emothoiy D, Masalion T, et al. Relationship of blood pressure, antihypertensive therapy,and outcome in ischemic stroke treated with intravenous thrombolysis[J]. Stroke, 2009, 40(7): 2442-2449.
4.	Bhatt AC, Farooq MU, Thomas DD, et al. Prognostic significance of blood pressure variability after thrombolysis in acute stroke[J]. Neurology, 2009, 72(20): 1793.
5.	Perini F, De Boni A, Marcon M, et al. Systolic blood pressure contributes to intracerebral haemorrhage after thrombolysis for ischemic stroke[J]. J Neurol Sci, 2010, 297(1-2): 52-54.
6.	Mokin M, Kass-Hout T, Kass-Hout O, et al. Blood pressure management and evolution of thrombolysis-associated intracerebral hemorrhage in acute ischemic stroke[J]. J Stroke Cerebrovasc Dis, 2011, 40(2): 462-468.
7.	Tsivgoulis G, Kotsis V, Giannopoulos S, et al. Intravenous thrombolysis for acute ischaemic stroke: effective blood pressure control matters[J]. Int J Stroke, 2011, 6(2): 125-127.
8.	曾红, 王雪红, 戚晓昆, 等. 爱通立溶栓治疗急性脑梗死伴出血[J]. 中华急诊医学杂志, 2006, 15(5): 77-79.
9.	Zinkstok SM, Vermeulen M, Stam J, et al. A randomised controlled trial of antiplatelet therapy in combination with Rt-PA thrombolysis in ischemic stroke: rationale and design of the ARTIS-Trial[J]. Trials, 2010(11): 51.
10.	Pancioli AM, Broderick J, Brott T, et al. The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial[J]. Stroke, 2008, 39(12): 3268-3276.
11.	Ahmed N, Wahlgren N, Brainin M, et al. Relationship of blood pressure, antihypertensive therapy and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR)[J]. Stroke, 2009, 40(7): 2442-2449.

1. 　姚敏, 吴江. 急性脑梗死溶栓治疗的研究与展望[J]. 中风与神经疾病杂志, 2007, 24(1): 123-128.
2. 　Kenneth B, Søren C,Dormiaty T. et al. Postthrombolysis blood pressure elevation is associated with hemorrhagic transformation[J]. Stroke, 2010, 41(1): 72-77.
3. 　Ahmed N, Emothoiy D, Masalion T, et al. Relationship of blood pressure, antihypertensive therapy,and outcome in ischemic stroke treated with intravenous thrombolysis[J]. Stroke, 2009, 40(7): 2442-2449.
4. 　Bhatt AC, Farooq MU, Thomas DD, et al. Prognostic significance of blood pressure variability after thrombolysis in acute stroke[J]. Neurology, 2009, 72(20): 1793.
5. 　Perini F, De Boni A, Marcon M, et al. Systolic blood pressure contributes to intracerebral haemorrhage after thrombolysis for ischemic stroke[J]. J Neurol Sci, 2010, 297(1-2): 52-54.
6. 　Mokin M, Kass-Hout T, Kass-Hout O, et al. Blood pressure management and evolution of thrombolysis-associated intracerebral hemorrhage in acute ischemic stroke[J]. J Stroke Cerebrovasc Dis, 2011, 40(2): 462-468.
7. 　Tsivgoulis G, Kotsis V, Giannopoulos S, et al. Intravenous thrombolysis for acute ischaemic stroke: effective blood pressure control matters[J]. Int J Stroke, 2011, 6(2): 125-127.
8. 　曾红, 王雪红, 戚晓昆, 等. 爱通立溶栓治疗急性脑梗死伴出血[J]. 中华急诊医学杂志, 2006, 15(5): 77-79.
9. 　Zinkstok SM, Vermeulen M, Stam J, et al. A randomised controlled trial of antiplatelet therapy in combination with Rt-PA thrombolysis in ischemic stroke: rationale and design of the ARTIS-Trial[J]. Trials, 2010(11): 51.
10. 　Pancioli AM, Broderick J, Brott T, et al. The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial[J]. Stroke, 2008, 39(12): 3268-3276.
11. 　Ahmed N, Wahlgren N, Brainin M, et al. Relationship of blood pressure, antihypertensive therapy and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR)[J]. Stroke, 2009, 40(7): 2442-2449.

West China Medical Journal

Analysis of the Apoplexy Score and Blood Pressure of the Cerebral Infarction Patients with Recombinant Human Tissue Fibrinolytic Enzyme Original Activators Thrombolysis

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