Analysis on Clinical Characteristics of Infectious Mononucleosis in Children_West China Medical Journal

Authors：

XU Yuxia , LIAO Xianhua , YI Zhigang , LIU Zengrong

Department of Pediatrics, The Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R.China;

Corresponding author：

Keywords：

传染性单核细胞增多症; 临床特点; 更昔洛韦

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【摘要】目的探讨儿童传染性单核细胞增多症（IM）的临床特点。方法回顾性分析2005年8月-2009年8月收治的151例IM患儿的症状、体征、实验室检查及治疗效果。结果 IM临床表现以发热、咽峡炎、肝脾和淋巴结肿大最常见，鼻塞、眼睑浮肿也是重要体征。外周血出现异型淋巴细胞及EBV-IgM抗体检测可帮助确诊。更昔洛韦治疗IM效果确切。结论应重视IM临床特点，有助于早期诊断并提高确诊率，应用更昔洛韦治疗值得推广。
【Abstract】 Objective To investigate the clinical features of infectious mononucleosis (IM) in children. Methods A total of 151 children with infectious mononucleosis admitted from August 2005 to August 2009 were reviewed. The symptoms, signs, laboratory tests, and treatment of infectious mononucleosis were analyzed. Results Fever, angina, hepatomegaly, splenomegaly, and swollen lymph nodes were the most common clinical manifestations of IM. Nasal congestion and eyelid edema were also two important signs. Atypical lymphocytes in peripheral blood and EBV antibody (VCA-IgM) could help confirm the diagnosis. The antiviral treatment with ganciclovir was effective for infectious mononucleosis. Conclusion Clinical features of infectious mononucleosis are helpful to the diagnosis. Treatment with ganciclovir should be promoted.

Citation： XU Yuxia,LIAO Xianhua,YI Zhigang,LIU Zengrong. Analysis on Clinical Characteristics of Infectious Mononucleosis in Children. West China Medical Journal, 2010, 25(7): 1270-1272. doi: Copy

1.	胡亚美, 江载芳. 实用儿科学[M]. 北京: 人民卫生出版社, 2002: 821.
2.	朱易平, 高举, 杜惠容, 等. 196例传染性单核细胞增多症的并发症和实验室检查[J]. 实用临床儿科杂志, 2003, 18(11): 902.
3.	Kanegane H, Kanegane C, Yachie A, et al. Infectious mononucleosis as a disease of early childhood in Japan caused by primary Epstein-Barr virus infection[J]. Acta Paediatr Jpn, 1997, 39(2): 166-171.
4.	刘增荣, 王嵩忠, 魏钰书, 等. 儿童传染性单核细胞增多症57例临床及实验室分析[J]. 川北医学院学报, 2006, 21(2): 139-141.
5.	朴金花, 孙景辉, 杨思睿, 等. 儿童传染性单核细胞增多症临床特点与发病年龄的关系(附142例分析)[J]. 中国小儿血液, 2005, 10(2): 71-74.
6.	王晓莉, 于洁, 徐西华. 传染性单核细胞增多症及其相关疾病临床特点分析[J]. 中国实用儿科杂志, 2006, 21(9): 696-698.
7.	张爱民, 贺湘玲. 182例小儿传染性单核细胞增多症的血液学表现[J]. 中国小儿血液, 2005, 10(1): 12-13.
8.	方在军, 毛平惠, 朱朝敏. 儿童传染性单核细胞增多症的肝脏损害特点[J]. 中国当代儿科杂志, 2003, 5(2): 153.
9.	Chan CW, Chiang AK, Chan KH, et al. Epstein-Barr virus-associated infectious mononucleos Chinese children[J]. Pediatr Infect Dis J, 2003, 22(11): 974.
10.	赵晓庆, 张宝玺, 吴晓莉. 慢性活动性EB病毒感染转为恶性淋巴瘤1例[J]. 中国实用儿科杂志, 2008, 23(2): 105.
11.	郭霞, 李强, 周晨燕, 等. 儿童传染性单核细胞增多症并发EB病毒相关性噬血综合征临床危险因素分析[J]. 中华儿科杂志, 2008, 48(1): 72.
12.	李奇志, 朱朝敏. 更昔洛韦治疗小儿传染性单核细胞增多症的临床疗效观察[J]. 中国实用儿科杂志, 2006, 21(1): 74.
13.	邓佳, 鄢力, 罗苇. 传染性单核细胞增多症的抗病毒治疗分析[J]. 现代预防医学, 2005, 32(2): 148.

1. 胡亚美, 江载芳. 实用儿科学[M]. 北京: 人民卫生出版社, 2002: 821.
2. 朱易平, 高举, 杜惠容, 等. 196例传染性单核细胞增多症的并发症和实验室检查[J]. 实用临床儿科杂志, 2003, 18(11): 902.
3. Kanegane H, Kanegane C, Yachie A, et al. Infectious mononucleosis as a disease of early childhood in Japan caused by primary Epstein-Barr virus infection[J]. Acta Paediatr Jpn, 1997, 39(2): 166-171.
4. 刘增荣, 王嵩忠, 魏钰书, 等. 儿童传染性单核细胞增多症57例临床及实验室分析[J]. 川北医学院学报, 2006, 21(2): 139-141.
5. 朴金花, 孙景辉, 杨思睿, 等. 儿童传染性单核细胞增多症临床特点与发病年龄的关系(附142例分析)[J]. 中国小儿血液, 2005, 10(2): 71-74.
6. 王晓莉, 于洁, 徐西华. 传染性单核细胞增多症及其相关疾病临床特点分析[J]. 中国实用儿科杂志, 2006, 21(9): 696-698.
7. 张爱民, 贺湘玲. 182例小儿传染性单核细胞增多症的血液学表现[J]. 中国小儿血液, 2005, 10(1): 12-13.
8. 方在军, 毛平惠, 朱朝敏. 儿童传染性单核细胞增多症的肝脏损害特点[J]. 中国当代儿科杂志, 2003, 5(2): 153.
9. Chan CW, Chiang AK, Chan KH, et al. Epstein-Barr virus-associated infectious mononucleos Chinese children[J]. Pediatr Infect Dis J, 2003, 22(11): 974.
10. 赵晓庆, 张宝玺, 吴晓莉. 慢性活动性EB病毒感染转为恶性淋巴瘤1例[J]. 中国实用儿科杂志, 2008, 23(2): 105.
11. 郭霞, 李强, 周晨燕, 等. 儿童传染性单核细胞增多症并发EB病毒相关性噬血综合征临床危险因素分析[J]. 中华儿科杂志, 2008, 48(1): 72.
12. 李奇志, 朱朝敏. 更昔洛韦治疗小儿传染性单核细胞增多症的临床疗效观察[J]. 中国实用儿科杂志, 2006, 21(1): 74.
13. 邓佳, 鄢力, 罗苇. 传染性单核细胞增多症的抗病毒治疗分析[J]. 现代预防医学, 2005, 32(2): 148.

West China Medical Journal

Analysis on Clinical Characteristics of Infectious Mononucleosis in Children

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