Effect of Age and Method of Preparing Endometrium on the Pregnancy Rate of Frozen-Thawed Embryo Transfer in Treatment of Infertility_West China Medical Journal

Authors：

HE Zhen , ZHU Minghui ,  YANG Dan

The Second Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 610041, P.R.China;

Corresponding author：

YANG Dan, Email: hezhen6655@sina.com

Keywords：

冻融胚胎移植; 自然周期; 激素替代周期; 临床妊娠率

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【摘要】目的探讨不同年龄段和不同内膜准备方法对冻融胚胎移植（FET）妊娠率的影响。方法回顾性分析2007年3月-2009年8月107例患者131个FET周期，比较不同年龄段、不同内膜准备方法的妊娠情况。结果 ① lt;29岁、30～34岁、≥35岁患者的周期临床妊娠率分别为45.28%、37.88%、33.33%，比较无统计学意义（P gt;0.05）。②自然周期和激素替代周期内膜准备，两种方法患者平均年龄、平均移植胚胎数、胚胎评分及胚胎细胞数比较无统计学意义（P gt;0.05），但自然周期的胚胎种植率及周期临床妊娠率均明显低于激素替代周期（16.78%比29.21%；29.51%比50.00%），比较有统计学意义（P lt;0.05）。结论患者年龄不影响FET周期临床妊娠率，激素替代周期内膜准备的FET胚胎种植率及周期临床妊娠率明显高于自然周期。
【Abstract】 Objective To analyze the effect of age and method of preparing endometrium on the pregnancy rate of frozen-thawed embryo transfer (FET) among infertile women. Methods Retrospective analysis was made on 131 FET cycles in 107 patients from March 2007 to August 2009. The relationship between pregnancy rate of FET and following factors were analyzed: age, the method of preparing uterus endometrium. Results ①There was no significant difference in pregnancy rate of FET among ＜29, 30 - 34, and ≥35 years old patients (45.28%, 37.88%, and 33.33%, respectively) (P gt;0.05). ②There was no significant difference in patients’ age, the average embryo amount, embryo score, the cell amount in every embryo between the FET with hormone replacement therapy (HRT) and the FET with natural cycle (NC). The embryo implantation rate and pregnancy rate of FET with NC were lower significantly than those of FET with HRT (16.78% vs 29.21%; 29.51% vs 50.00%) (P＜0.05). Conclusion Age might not influence pregnancy rate of FET. FET with HRT has higher implantation rate and pregnancy rate than FET with NC.

Citation： HE Zhen,ZHU Minghui,YANG Dan. Effect of Age and Method of Preparing Endometrium on the Pregnancy Rate of Frozen-Thawed Embryo Transfer in Treatment of Infertility. West China Medical Journal, 2010, 25(7): 1310-1312. doi: Copy

1.	Trounson A, Mohr L. Human pregnancy following cryopreservation, thawing and transfer of an eight-cell stage humanembryo[J]. Nature, 1983, 305(5936): 707-709.
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7.	李洁, 庄广伦. 子宫内膜功能异常与反复流产[J]. 中国实用妇科与产科杂志, 1999, 15(3): 141-143.
8.	Muasher SJ, Kruithoff C, Simonetti S, et al. Controlled preparation of the endometrium with exogenous steroids for the transfer of frozen-thawed pre-embryos in patients with anovulatory or irregular cycles[J]. Hum Reprod, 1991, 6(3): 443-445.
9.	Dal Prato L, Borini A, Cattoli M, et al. Endometrial preparation for frozen-thawed embryo transfer with or without pretreatment with gonadotropin-releasing hormone agonist[J]. Fertil Steril, 2002, 77(5): 956-960.

1. Trounson A, Mohr L. Human pregnancy following cryopreservation, thawing and transfer of an eight-cell stage humanembryo[J]. Nature, 1983, 305(5936): 707-709.
2. Ubaldi CF, Rienzi L, Baroni E, et al. Cumulative pregnancy rates after transfer of fresh and thawed embryos[J]. Eur J Obstetrics Gynecol Reprod Biol, 2004, 115(7): 106-109.
3. Alama P, Melo MAB, Garcia G, et al. Higher ongoing pregnancy rates in blastocyst transfer of frozen-thawed embryos in natural cycles than in hormone replacement therapy cycles[J]. Fertil Steril, 2007, 88(9): s161.
4. 李豫峰, 朱桂金, 章汉旺, 等. 三种冻融胚胎移植内膜准备方法的比较[J]. 生殖与避孕, 2009, 29(2): 113-116.
5. 谭真. 影响冻融胚胎移植结果的因素分析[J]. 中华现代妇产科学杂志, 2005, 2(8): 692-695.
6. Borini A, Maccolini A, Bianchi L, et al. Oocyte donation program: pregnancy and implantation rates in women of different ages sharing oocytes from single donor[J]. Fertil Steril, 1996, 65(1): 94-97.
7. 李洁, 庄广伦. 子宫内膜功能异常与反复流产[J]. 中国实用妇科与产科杂志, 1999, 15(3): 141-143.
8. Muasher SJ, Kruithoff C, Simonetti S, et al. Controlled preparation of the endometrium with exogenous steroids for the transfer of frozen-thawed pre-embryos in patients with anovulatory or irregular cycles[J]. Hum Reprod, 1991, 6(3): 443-445.
9. Dal Prato L, Borini A, Cattoli M, et al. Endometrial preparation for frozen-thawed embryo transfer with or without pretreatment with gonadotropin-releasing hormone agonist[J]. Fertil Steril, 2002, 77(5): 956-960.

West China Medical Journal

Effect of Age and Method of Preparing Endometrium on the Pregnancy Rate of Frozen-Thawed Embryo Transfer in Treatment of Infertility

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