Association among Fructosamine and Blood Glucose, Glycated Hemoglobin_West China Medical Journal

Authors：

YU Ting , HUANG Zhigang

Department of Laboratory Medicine, Clinical Chemistry Division, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;

Corresponding author：

Keywords：

果糖胺; 糖尿病; 血糖; 糖化血红蛋白

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【摘要】目的探讨果糖胺（fructosamine，FMN）与血糖、糖化血红蛋白（HbA1c）的关系。方法 2009年5月-2009年8月，以75例糖尿病患者作为糖尿病组，36例健康志愿者作为正常对照组，进行口服糖耐量试验，检测其空腹血糖及餐后2 h血糖水平，并同时检测FMN与HbA1c水平。结果糖尿病组空腹血糖、餐后2 h血糖、FMN、HbA1c均高于正常对照组（P lt;0.05）。FMN与HbA1c、空腹血糖、餐后2 h血糖均呈正相关关系（P lt;0.05）。FMN与空腹血糖的相关系数高于HbA1c与空腹血糖的相关系数，FMN与餐后血糖的相关系数也高于HbA1c与餐后血糖的相关系数。结论果糖胺与HbA1c相比有一定的优势，可作为监测糖尿病患者血糖控制的良好指标。
【Abstract】Objective To investigate the association among fructosamine (FMN) and blood glucose, glycated hemoglobin (HbA1c). Methods From May 2009 to April 2009, 75 diabetes and 36 health subjects were recruited for this study. Blood samples was collected and assayed for FMN, HbA1C, and fasting glucose.The 2-hour oral glucose tolerance test (OGTT-2h) was given. Results Fasting glucose, OGTT-2h glucose, FMN and HbA1c were all higher in diabetes group than in healthy control group (P lt;0.05) .There was positive correlation between FMN and fasting glucose, OGTT-2h glucose, and HbA1c (P lt;0.05). The correlation coefficients between FMN and glucose were higher than those between HbA1c and glucose. Conclusion Compared with HbA1c, FMN has advantage in monitoring blood glucose in diabetes and be regarded as a suitable index for blood glucose control.

Citation： YU Ting,HUANG Zhigang. Association among Fructosamine and Blood Glucose, Glycated Hemoglobin. West China Medical Journal, 2010, 25(7): 1325-1327. doi: Copy

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1. 贾伟平. 血糖控制达标是预防糖尿病并发症的关键[J]. 上海医学, 2005, 28(1): 1-3.
2. Kimberly MM, Vesper HW, Caudill SP, et al. Variability among five over-the-counter blood glucose monitors[J]. Clinica Chimica Acta, 2006, 364(1-2): 292-297.
3. Kendall DM, Kaplan RA, Paulson CF, et al. Accuracy and utility of a 10-test disk blood glucose meter[J]. Diabetes Res Clini Practice, 2005, 67(1): 29-35.
4. Parramon M. Easier and more comfortable measurement of capillary glycemia: the objective of a new electrochemical coulometric device “freestyle papillon mini”[J]. Revista de Enfermeria. 2005, 28(9): 53-56.
5. Saudek CD, Derr RL, Kalyani RR. Assessing glycemia in diabetes using self-monitoring blood glucose and hemoglobin A1c[J]. JAMA, 2006, 295(14): 1688-1697.
6. Taylor JR, Campbell KM. Home monitoring of glucose and blood pressure[J]. Am Fam Physician, 2007, 76(2): 255-260.
7. Renard E. Monitoring glycemic control: the importance of self-monitoring of blood glucose[J]. Am J Med, 2005, 118(Suppl 9A): 12S-19S.
8. Klonoff DC. Serum fructosamine as a screening test for type 2 diabetes[J]. Diabetes Technol Ther, 2000, 2(4): 537-539.
9. Lindsey CC, Carter AW, Mangum S, et al. A prospective, randomized, multicentered controlled trial to compare the annual glycemic and quality outcomes of patients with diabetes mellitus monitored with weekly fructosamine testing versus usual care[J]. Diabetes Technol Ther, 2004, 6(3): 637-642.
10. Misciagna G, Logroscino G, De Michele G, et al. Fructosamine, glycated hemoglobin, and dietary carbohydrates[J]. Clin Chim Acta, 2004, 340(1-2): 139-147.
11. Monnier L, Lapinski H, Colette C. Contributions of fasting and postprandial plasma glucose increments to the overall diurnal hyperglycemia of type 2 diabetic patients: variations with increasing levels of HbA(1c)[J]. Diabetes Care, 2003, 26: 881-885.
12. 胡兴国, 张云翔, 曾因明．危重病人应激性高血糖的研究进展[J]．国外医学•麻醉学与复苏分册, 2005, 26(3): 140-143．.

West China Medical Journal

Association among Fructosamine and Blood Glucose, Glycated Hemoglobin

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