Analysis Literature of Fenotibrate-Induced ADRS_West China Medical Journal

Authors：

CHENG Kai , XU Ting ,  TANG Yao , HU Haibo

Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R.China;

Corresponding author：

TANG Yao, Email: nedvedfsk@163.com

Keywords：

非诺贝特; 不良反应; 文献分析

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【摘要】目的 探讨非诺贝特致药品不良反应（ADRs）的一般规律和特点。方法检索PubMed（1978年-2009年8月）、中国期刊全文数据库CNKI（1980年-2009年8月）、中国生物医学文献数据库CBMDise（1980年-2009年8月）非诺贝特所致ADRs文献，进行统计、分析。结果非诺贝特致ADRs多发生在 gt;40岁年龄段，与性别无显著关联；64例ADRs主要涉及骨骼肌肉系统、消化系统、泌尿生殖系统、过敏反应，及时处理者预后良好。结论临床上应重视非诺贝特所致ADRs，及时处理。
【Abstract】 Objective To analyse the clinical features, correlation factors, preventions and cures of (adverse drug reactions, ADRs) caused by fenofibrate. Methods The cases of ADRs caused by fenofibrate were collected and analyzed from Pubmed (1978 - August 2009), CNKI (1980 - August 2009) and CBMDise (1980 - August 2009). Results Fenofibrate-induced ADRs were mostly seen in patients over 40 years old, but which was independent for sex. Totally, 64 ADRs were involved in the skeletal musculature system, digestive system, urinogenital system, and allergic response. The prognosis was favorable. Conclusion More attention should be given to patients with fenofibrate and ADRs should be treated as soon as possibile.

Citation： CHENG Kai,XU Ting,TANG Yao,HU Haibo. Analysis Literature of Fenotibrate-Induced ADRS. West China Medical Journal, 2010, 25(8): 1536-1538. doi: Copy

1.	张象麟, 张培培, 赖琪, 等. 药物临床信息参考2008[M]. 成都: 四川科学技术出版社, 2008: 633.
2.	高瑞通, 李航, 于阳, 等. 非诺贝特单独治疗引起横纹肌溶解症临床分析（附3例报告）[J]. 北京医学, 2005, 27(11): 656-658.
3.	陈桂芬, 王冬梅, 刘蓉昕, 等. 贝特类调脂药的合理应用[J]. 中国社区医师, 2009, 6(25): 19-20.
4.	杨世杰, 杨宝峰, 王怀良, 等. 药理学[M]. 北京: 人民卫生出版社, 2005: 342.
5.	Shitara Y, Hirano M. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2-mediated hepatic uptake and CYP2 C8-mediated metabolism of cerivastatin[J]. J Pharmacol Exp Ther, 2004, 311(1): 228-236.
6.	赵连礼, 于纪风. 非诺贝特致肝损伤和横纹肌溶解1例[J]. 临床荟萃, 2009, 24(1): 32.
7.	Huerta-Alardin AL, Varon J, Marik PE. Bench-to-bedside review: rhabdomyolysis-an overview for clinicians[J]. Crit Care, 2005, 9(2): 158-69.
8.	苏磊孟, 繁苏. 横纹肌溶解的病理生理及诊治[J]. 中华急诊医学杂志, 2007, 16(11): 1231-1234.
9.	梁茂本. 他汀类药物引起横纹肌溶解的原因及其防治[J]. 医学理论与实践, 2003, 16(10): 1140-1141.
10.	陈龙英, 陆华. 非诺贝特致男性性功能障碍例[J]. 中国现代应用药学, 2003, 14(5): 62.
11.	Dohmen K, Wen CY, Nagaoka S, et al. Fenofi brate-induced liver injury[J]. World J Gastroenterol, 2005, 11(48): 7702-7703.

1. 张象麟, 张培培, 赖琪, 等. 药物临床信息参考2008[M]. 成都: 四川科学技术出版社, 2008: 633.
2. 高瑞通, 李航, 于阳, 等. 非诺贝特单独治疗引起横纹肌溶解症临床分析（附3例报告）[J]. 北京医学, 2005, 27(11): 656-658.
3. 陈桂芬, 王冬梅, 刘蓉昕, 等. 贝特类调脂药的合理应用[J]. 中国社区医师, 2009, 6(25): 19-20.
4. 杨世杰, 杨宝峰, 王怀良, 等. 药理学[M]. 北京: 人民卫生出版社, 2005: 342.
5. Shitara Y, Hirano M. Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2-mediated hepatic uptake and CYP2 C8-mediated metabolism of cerivastatin[J]. J Pharmacol Exp Ther, 2004, 311(1): 228-236.
6. 赵连礼, 于纪风. 非诺贝特致肝损伤和横纹肌溶解1例[J]. 临床荟萃, 2009, 24(1): 32.
7. Huerta-Alardin AL, Varon J, Marik PE. Bench-to-bedside review: rhabdomyolysis-an overview for clinicians[J]. Crit Care, 2005, 9(2): 158-69.
8. 苏磊孟, 繁苏. 横纹肌溶解的病理生理及诊治[J]. 中华急诊医学杂志, 2007, 16(11): 1231-1234.
9. 梁茂本. 他汀类药物引起横纹肌溶解的原因及其防治[J]. 医学理论与实践, 2003, 16(10): 1140-1141.
10. 陈龙英, 陆华. 非诺贝特致男性性功能障碍例[J]. 中国现代应用药学, 2003, 14(5): 62.
11. Dohmen K, Wen CY, Nagaoka S, et al. Fenofi brate-induced liver injury[J]. World J Gastroenterol, 2005, 11(48): 7702-7703.

West China Medical Journal

Analysis Literature of Fenotibrate-Induced ADRS

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