Treatment of Primary Hepatic Carcinoma with Three-Dimensional Conformal Radiation Therapy Combined with Transcatheter Arterial Chemoembolization_West China Medical Journal

Authors：

1.Department of Oncology, Jiangyou City Steel General Hospital, Jiangyou, Sichuan 621701, P.R.China; 2.Department of Oncology, the People’s Hospital of Langzhong, Langzhong, Sichuan 637400, P.R.China;

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Keywords：

原发性肝癌; 三维适形放疗; 化疗栓塞

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【摘要】目的 探讨三维适形放疗(3DCRT)联合介入栓塞化疗(TACE)治疗Ⅲ、Ⅳ期原发性肝癌的方法和临床价值。方法回顾性总结2006年6月-2008年12月采用3DCRT联合TACE治疗原发性肝癌的临床资料40例。结果 3DCRT联合TACE治疗Ⅲ、Ⅳ期原发性肝癌有效率为85%。0.5、1、2年局部控制率分别为92%、70%、52%。0.5、1、2年生存率分别为75%、46%、30%，治疗不良反应轻微。结论 3DCRT联合TACE能提高原发性肝癌患者生活质量，延长生存期,是治疗中晚期原发性肝癌的有效治疗方法之一。
【Abstract】 Objective To investigate the application and clinical value of three-dimensional conformal radiation therapy (3DCRT) combined with transcatheter arterial chemoembolization (TACE) on stage Ⅲ and Ⅳ primary hepatic carcinoma. Methods A Total of 40 cases of stage Ⅲ and Ⅳ primary hepatic carcinoma treated by 3DCRT combined with TACE from June 2006 to December 2008 were analyzed retrospectively. Results The response rate was 85%. The 0.5-, 1-, and 2-year local response rates were 92%, 70%, and 52%, and the 0.5-, 1-, and 2-year survival rates were 75%, 46%, and 30%, respectively. The adverse reactions of radiotherapy were tolerable. Conclusion 3DCRT combined with TACE could improve prognosis of stage Ⅲ and Ⅳprimary hepatic carcinoma.

Citation： HU Gaowu,DONG Ling. Treatment of Primary Hepatic Carcinoma with Three-Dimensional Conformal Radiation Therapy Combined with Transcatheter Arterial Chemoembolization. West China Medical Journal, 2010, 25(9): 1594-1596. doi: Copy

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1. Sheng JM, Zhao WH, Wu FS, et al. The Chinese classification system compared with TNM staging in prognosis of patients with primary hepatic carcinoma after resection[J]. Hepatobiliary Pancreat Dis Int, 2005, 4(4): 561-564.
2. Cheng HY, Wang XY, Zhao GL, et al. Imaging findings and transcatheter arterial chemoembolization of hepatic malignancy with right atrial embolus in 46 patients[J]. World J Gastroenterol, 2008, 14(22): 3563-3568.
3. Liang SX, Zhu XD, Lu HJ, et al. Hypofractionated three-dimensional conformal radiation therapy for primary liver carcinoma[J]. Cancer, 2005, 103(10): 2181-2188.
4. Zhou ZH, Liu LM, Chen WW, et al. Combined therapy of transcatheter arterial chemoembolisation and three-dimensional conformal radiotherapy for hepatocellular carcinoma[J]. Br J Radiol, 2007, 80(951): 194-201.
5. Zhao JD, Xu ZY, Zhu J, et al. Application of active breathing control in 3-dimensional conformal radiation therapy for hepatocellular carcinoma: the feasibility and benefit[J]. Radiother Oncol, 2008, 87(3): 439-444.
6. Lin CS, Jen YM, Chiu SY, et al. Treatment of portal vein tumor thrombosis of hepatoma patients with either stereotactic radiotherapy or three-dimensional conformal radiotherapy[J]. Jpn J Clin Oncol, 2006, 36(4): 212-217.

West China Medical Journal

Treatment of Primary Hepatic Carcinoma with Three-Dimensional Conformal Radiation Therapy Combined with Transcatheter Arterial Chemoembolization

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