【摘要】 目的  观察氨甲环酸在肝切除术中止血的有效性和安全性及对凝血功能的影响。 方法  将2009年3-11月间收治的50例肝切除患者，随机分为对照组（C组)和氨甲环酸组（T组)各25例。T组给予氨甲环酸100 mg/kg（总量≤5 g)，C组给予等量生理盐水。于术前30 min先给予负荷量20 mL，剩下的则静脉泵入，泵注速度均为15mL/h。观察患者术中及术后出血和输血总量，比较患者术前和术后24 h血常规和凝血功能状态。 结果  患者术前的一般情况无统计学差异(P gt;0.05)。T组患者的术中出血和输血量均低于C组（P lt;0.05)，且术后凝血功能改变无统计学意义(P gt;0.05)。 结论  氨甲环酸在肝切除术中可以有效减少出血和输血量，且对术后凝血功能无显著影响，无严重不良反应，是一种安全有效的止血药物。
【Abstract】 Objective  To observe the efficiency and safety of tranexamic acid on reducing the hemorrhage in hepatectomy and the effect on blood coagulation. Methods  A total of 50 patients with hepatocellular carcinoma who underwent hepatectomy from March to November 2009 were randomly divided into the control group (Group C, n=25) and the tranexamic acid group (Group T, n=25). The patients in Group T were administered to with tranexamic acid (100 g/kg), and the total dosage was not more than 5 g. The patients in Group C were administered to with normal saline, and the dosage was the same as the Group T. Both groups were given loading dose 20 ml, and the rest was intravenous pumped by 15 mL/h. The total bleeding volume, blood transfusion, blood routine and coagulation before surgery and 24 hours after surgery were compared between the two groups. Results  The backgrounds, operative procedures did not differ much between the two groups. The total bleeding volume and blood transfusion in Group T were less than that in Group C, and coagulation did not changed evidently. Conclusion  In the operation of hepatectomy, tranexamic acid can decrease hemorrhage and transfusion effectively, and would not change coagulation and has no serious adverse effect. It is a kind of safe and effective antihemorrhagic.

Citation： YANG Hongming,LI Bing,YIN Wei,LI Changmin. Effect of Tranexamic Acid on Reducing Hemorrhage in Hepatectomy. West China Medical Journal, 2010, 25(9): 1698-1700. doi: Copy