Expression of Interleukin-18 in Active Rheumatoid Arthritis Patients_West China Medical Journal

Authors：

REN Min ¹ , WU Jiabiao ¹ , TANG LI ¹ , XIAO Jing ¹ , JIANG Lixin ²

1. Department of Rheumatology, 2. Department of Clinical Laboratory, Wujin Hospital, Changzhou, Jiangsu 213002, P.R. China;

Corresponding author：

Keywords：

类风湿关节炎; 白介素-18; 细胞因子

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

【摘要】　目的　研究活动期RA患者血清中细胞因子IL-18的表达，并探讨它们与疾病活动程度的关系。　方法　 2008年12月-2010年1月将63例RA患者，根据DAS28将患者分为高度活动组和低度活动组，应用酶联免疫吸附法（ELISA）法检测63例RA患者和27例对照组的白细胞介素-18（IL-18）表达水平。分析IL-18的水平与临床指标的相关性。　结果　 IL-18在活动期RA中表达水平高于低度活动组、对照组，分别为（238.88±41.75）、（189.11±40.62）、（185.42±44.93） pg/mL，有统计学意义（P lt;0.01）。RA活动组患者IL-18与外周血白细胞计数呈负相关（r=-0.628，P lt;0.05）。　结论　 IL-18水平在RA活动期患者高表达，在RA发病和发展中起重要作用。
【Abstract】　Objective　 To observe the expression of interleukin-18 (IL-18) in patients with active rheumatoid arthritis (RA).　Methods　 A total of 63 patients with RA in our hospital from December 2008 to January 2010 were selected. The patients were divided into high activity group and low activity group according to the disease activity score 28 (DAS28). Levels of IL-18 in the serum in 63 patients and 27 control individuals were detected by ELISA technique. The relationship between IL-18 expression and the clinical indexes was analyzed.　Results　 IL-18 serum levels were (238.88±41.75), (189.11±40.62), and (185.42±44.93) pg/mL In high activity group, low activity group and the control group respectively with a significant difference (P lt;0.01). The IL-18 level in high activity group was negative correlated with WBC counts.　Conclusion　 Apparent expression of IL-18 is found in RA patients at the active phase, which plays an important role in the occurrence and development of RA.

Citation： REN Min,WU Jiabiao,TANG LI,XIAO Jing,JIANG Lixin. Expression of Interleukin-18 in Active Rheumatoid Arthritis Patients. West China Medical Journal, 2010, 25(11): 2015-2017. doi: Copy

1.	Klareskog L, Catrina AI, Paget S, et al. Rheumatoid arthritis[J]. Lancet, 2009, 373(9664): 659-672.
2.	Shao XT, Feng L, Gu LJ, et al. Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis[J]. Clin Exp Med, 2009, 9(3): 215-221.
3.	曲瑾. 类风湿关节炎关节滑膜细胞中IL-18表达及意义[J]. 山东医药, 2008, 48(48): 99-100.
4.	李强, 黄宪章, 丁海明, 等. 外周血白细胞介素-18与类风湿性关节炎相关性研究[J]. 实用医学杂志, 2007, 23(8): 1143-1144.
5.	Boraschi D, Dinarello CA. IL-18 in autoimmunity: review[J]. Eur Cytokine Netw, 2006, 17(4): 224-252.
6.	Joosten LA, Radstake TR, Lubberts E, et al. Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis[J]. Arthritis Rheum, 2003, 48(2): 339-347.
7.	王叶萍, 姚航平. 类风湿性关节炎患者血清和滑液IL-18及IL-18结合蛋白的水平及意义[J]. 检验医学, 2004, 19(6): 518-520.
8.	Bresnihan B, Roux Lombard P, Murphy E, et al. Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis[J]. Ann Rheum Dis, 2002, 61(8): 726-729.
9.	Brown AK, Conaghan PG, Karim Z, et al. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis[J]. Arthritis Rheum, 2008, 58(10): 2958-2967.
10.	Bokarewa M, Hultgren O. Is interleukin-18 useful for monitoring rheumatoid arthritis [J]? Scand J Rheumatol, 2005, 34(6): 433-436.
11.	Muhl H, Pfeilschifter J. Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory interve-ntion[J]. Eur J Pharmacol, 2004, 500(1): 67-71.
12.	Dinarello CA. Interleukin-18 and the treatment of rheumatoid arthritis[J]. Rheum Dis Clin North Am, 2004, 30(2): 417-434.
13.	McInnes IB, Liew FY, Gracie JA, et al. Interleukin-18: a therapeutic target in rheumatoid arthritis [J] ? Arthritis Res Ther, 2005, 7(1): 38-41.

1. 　Klareskog L, Catrina AI, Paget S, et al. Rheumatoid arthritis[J]. Lancet, 2009, 373(9664): 659-672.
2. 　Shao XT, Feng L, Gu LJ, et al. Expression of interleukin-18, IL-18BP, and IL-18R in serum, synovial fluid, and synovial tissue in patients with rheumatoid arthritis[J]. Clin Exp Med, 2009, 9(3): 215-221.
3. 　曲瑾. 类风湿关节炎关节滑膜细胞中IL-18表达及意义[J]. 山东医药, 2008, 48(48): 99-100.
4. 　李强, 黄宪章, 丁海明, 等. 外周血白细胞介素-18与类风湿性关节炎相关性研究[J]. 实用医学杂志, 2007, 23(8): 1143-1144.
5. 　Boraschi D, Dinarello CA. IL-18 in autoimmunity: review[J]. Eur Cytokine Netw, 2006, 17(4): 224-252.
6. 　Joosten LA, Radstake TR, Lubberts E, et al. Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis[J]. Arthritis Rheum, 2003, 48(2): 339-347.
7. 　王叶萍, 姚航平. 类风湿性关节炎患者血清和滑液IL-18及IL-18结合蛋白的水平及意义[J]. 检验医学, 2004, 19(6): 518-520.
8. 　Bresnihan B, Roux Lombard P, Murphy E, et al. Serum interleukin 18 and interleukin 18 binding protein in rheumatoid arthritis[J]. Ann Rheum Dis, 2002, 61(8): 726-729.
9. 　Brown AK, Conaghan PG, Karim Z, et al. An explanation for the apparent dissociation between clinical remission and continued structural deterioration in rheumatoid arthritis[J]. Arthritis Rheum, 2008, 58(10): 2958-2967.
10. 　Bokarewa M, Hultgren O. Is interleukin-18 useful for monitoring rheumatoid arthritis [J]? Scand J Rheumatol, 2005, 34(6): 433-436.
11. 　Muhl H, Pfeilschifter J. Interleukin-18 bioactivity: a novel target for immunopharmacological anti-inflammatory interve-ntion[J]. Eur J Pharmacol, 2004, 500(1): 67-71.
12. 　Dinarello CA. Interleukin-18 and the treatment of rheumatoid arthritis[J]. Rheum Dis Clin North Am, 2004, 30(2): 417-434.
13. 　McInnes IB, Liew FY, Gracie JA, et al. Interleukin-18: a therapeutic target in rheumatoid arthritis [J] ? Arthritis Res Ther, 2005, 7(1): 38-41.

West China Medical Journal

Expression of Interleukin-18 in Active Rheumatoid Arthritis Patients

Abstract Full text Figures/Tables Video References Cited by

Format

Content