扁桃体滤泡树突状细胞肉瘤一例_West China Medical Journal

Authors：

余敏 , 姜愚

Corresponding author：

姜愚, Email:

Keywords：

扁桃体; 滤泡树突状细胞肉瘤

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【摘要】　目的　总结滤泡树突状细胞肉瘤的临床表现，诊断，病理分析及治疗。　方法　 2008年9-10月，对1例右扁桃体滤泡树突状细胞肉瘤患者，经CT、X线片查示确诊后，全麻下行双侧扁桃体切除术。　结果　术后病现学检查CD21（+），CD23（+），诊断为右扁桃体滤泡树突状细胞肉瘤，术后予CHOP方案化疗并行局部放疗。　结论　滤泡树突状肉瘤是一种罕见的肿瘤，确诊主要依靠免疫组织化学结果，手术是首选治疗，术后辅助放化疗效果目前不明确。

Citation： 余敏,姜愚. 扁桃体滤泡树突状细胞肉瘤一例. West China Medical Journal, 2010, 25(11): 2064-2066. doi: Copy

1.	Grogg KL, Lae ME, Kurtin PJ, et al. Clusterin expression distinguishes follicular dendritic cell tumors from other dendritic cell neoplasms: report of a novel follicular dendritic cell marker and clinicopathologic data on 12 additional follicular dendritic cell tumors and 6 additional interdigitating dendritic cell tumors[J]. Am J Surg Pathol, 2004, 28(8): 988-998.
2.	Perez-Ordonez B, Erlandson RA, Rosai J. Follicular dendritic cell tumor. Report of 13 additional cases of a distinctive entity[J]. Am J Surg Pathol, 1996, 20(8): 944-955.
3.	Chou YY, How SW, Huang GH. Follicular dendritic cell sarcoma of the soft palate[J]. J Formos Med Assoc, 2005, 104(11): 843-847.
4.	Krber SM, Marx A, Aebert H, et al. Sarcoma of follicular dendritic cells in the dorsal mediastinum[J]. Hum Pathol, 2004, 35(2): 259-263.
5.	Nakashima T, Kuratomi Y, Shiratsuchi H, et al. Follicular dendritic cell sarcoma of the neck: a case report and literature review[J]. Auris Nasus Larynx, 2002, 29(4): 401-403.
6.	Monda L, Warnke Rosai J. A primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation: a report of 4 cases[J]. Am J Pathol, 1986, 122: 562-572.
7.	曹雪涛. 树突状细胞的基础与临床研究新进展[J]. 中国免疫学杂志, 1998, 14(3): 161-168.
8.	Toyoda K, Taniguchi J, Kikawa K, et al. Follicular dendritic cell sarcoma: ultrastructural and immunohistochemical studies[J]. Intern Med, 2000, 39(11): 950-955.
9.	Bradshaw EJ, Wood KM, Hodgkinson P, et al. Follicular dendritic cell tumor in a 9-year-old child[J]. Pediatr Blood Cancer, 2005, 45(5): 725-727.
10.	Shia J, Chen W, Tang LH, et al. Extranodal follicular dendritic cell sarcoma: clinical, pathologic, and histogenetic characteristics of an underrecognized disease entity[J]. Virchows Arch, 2006, 449(2): 148-158.
11.	Chan JK, Fletcher CD, Nayler SJ. Follicular dendritic cell sarcoma: clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized[J]. Cancer, 1997, 79: 294-313.
12.	Chan AC, Chan KW, Chan JK. Development of follicular dendritic cell sarcoma in hyaline-vascular Castlemans disease of the nasopharyns: tracing its evolution sequential biopsies[J]. Histopathology, 2001, 38(6): 510-518.
13.	Torres U, Hawkins WG, Antonescu CR, et al. Hepatic follicular dendritic cell sarcoma without Epstein-Barr virus expression[J]. Arch Pathol Lab Med, 2005, 129(11): 1480-1483.
14.	周余, 李杰, 姚晓红, 等. 滤泡树突细胞肉瘤1例[J]. 中华血液学杂志, 2004, 25(10): 628.
15.	Perez-Ordonez B, Rosai J. Follicular dendritic cell tumor: review of the entity[J]. Semin Diagn Pathol, 1998, 15(2): 144-154.
16.	Wang, Kong Y, LU H, et al. Two cases of extranodal follicular dendritic cell sarcoma[J]. Chin Med J, 2003, 116(5): 794-797.
17.	Romero Guadarrama MB, Reyes Posada O, Hernndez Gonzlez MM, et al. Follicular dendritic cell sarcoma/tumor: 2 cases of a rare tumor of difficult clinical and pathological diagnosis[J]. Ann Diagn Pathol, 2009, 13(4): 257-262.
18.	皋岚湘, 丁华野. 关于组织细胞肿瘤分类的病理学新进展[J]. 诊断病理学杂志, 2003, 10(5): 303-306.
19.	Biddle DA, Ro JY, Yoon GS, et al. Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature[J]. Mod Pathol, 2002, 15(1): 50-58.
20.	Vargas H, Mouzakes J, Purdy SS, et al. Follicular dendritic cell tumor: an aggressive head and neck tumor[J]. Am J Otolaryngol, 2002, 23(2): 93-98.
21.	Xie Q, Chen L, Fu K, et al. Podoplanin(d2-40): a new immunohistochemical marker for reactive follicular dendritic cells and follicular dendritic cell sarcoma[J]. Int J Clin Exp Pathol, 2008, 1(3): 276-284.
22.	Yu H, Gibson JA, Pinkus GS, et al. Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors[J]. Am J Clin Pathol, 2007, 128(5): 776-782.
23.	Vermi W, Lonardi S, Bosisio D, et al. Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma[J]. J Pathol, 2008, 216(3): 356-364.
24.	Sun X, Chang KC, Abruzzo LV, et al. Epidermal growth factor receptor expression in follicular dendritic cells: a shared feature of follicular dendritic cell sarcoma and Castlemans disease[J]. Hum Pathol, 2003, 34(9): 835-840.
25.	Soriano AO, Thompson MA, Admirand JH, et al. Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature[J]. Am J Hematol, 2007, 82(8): 725-728.
26.	Nayler SJ, Taylor L, Cooper K. HHV-8 is not associated with follicular dendritic cell tumors[J]. Mol Pathol, 1998, 51(3): 168-170.
27.	Zhong GP, Sun WY, Gan MF, et al. Follicular dendritic cell sarcoma: a clinicopathologic study of five cases[J]. Zhonghua Bing Li Xue Za Zhi, 2006, 35(10): 612-615.
28.	Chan JKC. Proliferative lesions of follicular dendritic cells: an overview, including a detail account of follicular dendritic cell sarcoma, a neoplasm with many faces and uncommon etiologic associations[J]. Adv Anat Pathol, 1997, 4(6): 387-411.
29.	Shek TWH, Liu CL, Peh WCG, et al. Intra-abdominal follicular dendritic cell tumour: a rare tumour in need of recognition[J]. Histopathology, 1998, 33(5): 465-470.
30.	Pisani F, Marino M, Sentinelli S, et al. Follicular dendtritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin[J]. J Exp Clin Cancer Res, 2008, 27(1): 33.
31.	Ludwig A. Extanodal follicular dendritic cell sarcoma of the tonsils[J]. HNO, 2006, 54(9): 701-704.
32.	Azim HA, Elsedewy E, Azim HA Jr. Imatinib in the treatment of follicular dendritic sarcoma: a case report and review of literature[J]. Onkologie, 2007, 30(7): 381-384.
33.	Della Porta M, Rigolin GM, Bugli AM, et al. Differentiation of follicular dendritic sarcoma cells into functional myeloid-dendritic cell-like elements[J]. Eur J Haematol, 2003, 70(5): 315-318.
34.	Chera BS, Orlando C, Villaret DB, et al. Follicular dendritic cell sarcoma of the head and neck: case report and literature review[J]. Laryngoscope, 2008, 118(9): 1607-1612.
35.	Vaideeswar P, George SM, Kane SV, et al. Extranodal follicular cell sarcoma of the tonsil-case report of an epithelioid cell variant with osteoclstic giant cells[J]. Pathol Res Pract, 2009, 205(2): 149-153.

1. 　Grogg KL, Lae ME, Kurtin PJ, et al. Clusterin expression distinguishes follicular dendritic cell tumors from other dendritic cell neoplasms: report of a novel follicular dendritic cell marker and clinicopathologic data on 12 additional follicular dendritic cell tumors and 6 additional interdigitating dendritic cell tumors[J]. Am J Surg Pathol, 2004, 28(8): 988-998.
2. 　Perez-Ordonez B, Erlandson RA, Rosai J. Follicular dendritic cell tumor. Report of 13 additional cases of a distinctive entity[J]. Am J Surg Pathol, 1996, 20(8): 944-955.
3. 　Chou YY, How SW, Huang GH. Follicular dendritic cell sarcoma of the soft palate[J]. J Formos Med Assoc, 2005, 104(11): 843-847.
4. 　Krber SM, Marx A, Aebert H, et al. Sarcoma of follicular dendritic cells in the dorsal mediastinum[J]. Hum Pathol, 2004, 35(2): 259-263.
5. 　Nakashima T, Kuratomi Y, Shiratsuchi H, et al. Follicular dendritic cell sarcoma of the neck: a case report and literature review[J]. Auris Nasus Larynx, 2002, 29(4): 401-403.
6. 　Monda L, Warnke Rosai J. A primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation: a report of 4 cases[J]. Am J Pathol, 1986, 122: 562-572.
7. 　曹雪涛. 树突状细胞的基础与临床研究新进展[J]. 中国免疫学杂志, 1998, 14(3): 161-168.
8. 　Toyoda K, Taniguchi J, Kikawa K, et al. Follicular dendritic cell sarcoma: ultrastructural and immunohistochemical studies[J]. Intern Med, 2000, 39(11): 950-955.
9. 　Bradshaw EJ, Wood KM, Hodgkinson P, et al. Follicular dendritic cell tumor in a 9-year-old child[J]. Pediatr Blood Cancer, 2005, 45(5): 725-727.
10. 　Shia J, Chen W, Tang LH, et al. Extranodal follicular dendritic cell sarcoma: clinical, pathologic, and histogenetic characteristics of an underrecognized disease entity[J]. Virchows Arch, 2006, 449(2): 148-158.
11. 　Chan JK, Fletcher CD, Nayler SJ. Follicular dendritic cell sarcoma: clinicopathologic analysis of 17 cases suggesting a malignant potential higher than currently recognized[J]. Cancer, 1997, 79: 294-313.
12. 　Chan AC, Chan KW, Chan JK. Development of follicular dendritic cell sarcoma in hyaline-vascular Castlemans disease of the nasopharyns: tracing its evolution sequential biopsies[J]. Histopathology, 2001, 38(6): 510-518.
13. 　Torres U, Hawkins WG, Antonescu CR, et al. Hepatic follicular dendritic cell sarcoma without Epstein-Barr virus expression[J]. Arch Pathol Lab Med, 2005, 129(11): 1480-1483.
14. 　周余, 李杰, 姚晓红, 等. 滤泡树突细胞肉瘤1例[J]. 中华血液学杂志, 2004, 25(10): 628.
15. 　Perez-Ordonez B, Rosai J. Follicular dendritic cell tumor: review of the entity[J]. Semin Diagn Pathol, 1998, 15(2): 144-154.
16. 　Wang, Kong Y, LU H, et al. Two cases of extranodal follicular dendritic cell sarcoma[J]. Chin Med J, 2003, 116(5): 794-797.
17. 　Romero Guadarrama MB, Reyes Posada O, Hernndez Gonzlez MM, et al. Follicular dendritic cell sarcoma/tumor: 2 cases of a rare tumor of difficult clinical and pathological diagnosis[J]. Ann Diagn Pathol, 2009, 13(4): 257-262.
18. 　皋岚湘, 丁华野. 关于组织细胞肿瘤分类的病理学新进展[J]. 诊断病理学杂志, 2003, 10(5): 303-306.
19. 　Biddle DA, Ro JY, Yoon GS, et al. Extranodal follicular dendritic cell sarcoma of the head and neck region: three new cases, with a review of the literature[J]. Mod Pathol, 2002, 15(1): 50-58.
20. 　Vargas H, Mouzakes J, Purdy SS, et al. Follicular dendritic cell tumor: an aggressive head and neck tumor[J]. Am J Otolaryngol, 2002, 23(2): 93-98.
21. 　Xie Q, Chen L, Fu K, et al. Podoplanin(d2-40): a new immunohistochemical marker for reactive follicular dendritic cells and follicular dendritic cell sarcoma[J]. Int J Clin Exp Pathol, 2008, 1(3): 276-284.
22. 　Yu H, Gibson JA, Pinkus GS, et al. Podoplanin (D2-40) is a novel marker for follicular dendritic cell tumors[J]. Am J Clin Pathol, 2007, 128(5): 776-782.
23. 　Vermi W, Lonardi S, Bosisio D, et al. Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma[J]. J Pathol, 2008, 216(3): 356-364.
24. 　Sun X, Chang KC, Abruzzo LV, et al. Epidermal growth factor receptor expression in follicular dendritic cells: a shared feature of follicular dendritic cell sarcoma and Castlemans disease[J]. Hum Pathol, 2003, 34(9): 835-840.
25. 　Soriano AO, Thompson MA, Admirand JH, et al. Follicular dendritic cell sarcoma: a report of 14 cases and a review of the literature[J]. Am J Hematol, 2007, 82(8): 725-728.
26. 　Nayler SJ, Taylor L, Cooper K. HHV-8 is not associated with follicular dendritic cell tumors[J]. Mol Pathol, 1998, 51(3): 168-170.
27. 　Zhong GP, Sun WY, Gan MF, et al. Follicular dendritic cell sarcoma: a clinicopathologic study of five cases[J]. Zhonghua Bing Li Xue Za Zhi, 2006, 35(10): 612-615.
28. 　Chan JKC. Proliferative lesions of follicular dendritic cells: an overview, including a detail account of follicular dendritic cell sarcoma, a neoplasm with many faces and uncommon etiologic associations[J]. Adv Anat Pathol, 1997, 4(6): 387-411.
29. 　Shek TWH, Liu CL, Peh WCG, et al. Intra-abdominal follicular dendritic cell tumour: a rare tumour in need of recognition[J]. Histopathology, 1998, 33(5): 465-470.
30. 　Pisani F, Marino M, Sentinelli S, et al. Follicular dendtritic cell sarcoma of the neck: report of a case treated by surgical excision and COP plus (PEG)-liposomal doxorubicin[J]. J Exp Clin Cancer Res, 2008, 27(1): 33.
31. 　Ludwig A. Extanodal follicular dendritic cell sarcoma of the tonsils[J]. HNO, 2006, 54(9): 701-704.
32. 　Azim HA, Elsedewy E, Azim HA Jr. Imatinib in the treatment of follicular dendritic sarcoma: a case report and review of literature[J]. Onkologie, 2007, 30(7): 381-384.
33. 　Della Porta M, Rigolin GM, Bugli AM, et al. Differentiation of follicular dendritic sarcoma cells into functional myeloid-dendritic cell-like elements[J]. Eur J Haematol, 2003, 70(5): 315-318.
34. 　Chera BS, Orlando C, Villaret DB, et al. Follicular dendritic cell sarcoma of the head and neck: case report and literature review[J]. Laryngoscope, 2008, 118(9): 1607-1612.
35. 　Vaideeswar P, George SM, Kane SV, et al. Extranodal follicular cell sarcoma of the tonsil-case report of an epithelioid cell variant with osteoclstic giant cells[J]. Pathol Res Pract, 2009, 205(2): 149-153.

West China Medical Journal

扁桃体滤泡树突状细胞肉瘤一例

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