Initial Analysis of Correlation Factors of Leukoaraiosis_West China Medical Journal

Authors：

ZHOU Li ¹ , ZHOU Hongyu ²

1.The First Hospital of Neijiang，Neijiang Sichuan 641000;2.Department of Neurology，West China Hospital，Sichuan University，Chengdu 610041，China;

Corresponding author：

Keywords：

脑白质疏松症; 脑梗死; 磁共振成像

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目的：探讨单纯脑白质疏松症(LA)以及LA合并脑梗死及其MRI影像学严重程度与年龄、性别、高血压、糖尿病相关性初步分析。方法：根据郭氏等2003年制定的LA诊断标准纳入168例脑白质疏松症患者，分为A、B两组：A组95例为单纯脑白质疏松(LA)，B组73例为LA合并脑梗死(LA+CI)。两组患者均行头MRI检查。根据Kinkel等的方法将T2WI显示脑室周围高信号范围及程度分为5型.结果：年龄与脑白质疏松的严重程度呈线性相关性(P lt;0.05)，男性与女性间比较脑白质疏松的发生率无显著差异(P gt;0.05)，LA以及LA+CI患者，其高血压及糖尿病伴发率较高，而且LA+CI组高于LA组(高血压P lt;0.01，糖尿病P lt;0.01)，LA患者MRI表现以1型为主，LA+CI患者表现以2型为主，P lt;0.01)。结论：脑白质疏松症的严重程度与年龄密切相关，LA的发生率在男女性别间无明显差异。高血压、糖尿病可能是LA的危险因素。LA+CI组与单纯LA组相比，其高血压、糖尿病伴发率更高且MRI表现程度更重。

Citation： ZHOU Li,ZHOU Hongyu. Initial Analysis of Correlation Factors of Leukoaraiosis. West China Medical Journal, 2009, 24(2): 253-255. doi: Copy

1.
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8.	Wiszniewska M, Devuyst G, Bogousslavsky J,et al.What is the significance of leukoaraiosis in patients with acute ischemic stroke?[J]Arch Neurol，2000，57(7):967973.Comment in:Arch Neurol，2000，57(7):925-926..
9.	de Leeuw FE, de Groot JC, Achten E,et al.Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study[J].J Neurol Neurosurg Psychiatry,2001,70(1):914.Comment in:J Neurol Neurosurg Psychiatry,2001,70(1):2-3.
10.	de Leeuw FE,de Groot JC,Achten E,et al.Prevalence of cerebral white matter lesions in elderly people:a population based magnetic resonance imaging study.The Rotterdam Scan Study.
11.	Ostrow PT, Miller LL.Pathology of small artery disease[J].Adv Neurol,1993,62:93-123..
12.	Longstreth WT，Manollo TA，Arnold，et al.Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people[J].Stroke，1999，27(8)：12741282..
13.	Baloh RW，Vinters HV.White matter lesions and disequibrium in older people：1 case contol comparison[J].Arch Neurol，1995，52：975-981..

1.
2. Hachinski VC，Potter P，Merskey H.Leukoaraiosis[J].Arch Neurol，1987，44(1)：21-23..
3. 郭洪志.脑白质疏松症[J].临床神经病学杂志，2002，15：3-4..
4. 郭洪志，屈传强.Binswanger病与脑白质疏松症的鉴别与诊断标准[J].脑血管疾病杂志,2003，3：31-35..
5. Kinkel WR，lacobs L，Polachini L，et al，Subcortical arteriosclerotic encephalopathy(Binswanger’s disease)：computed tomographic，nuclear magnenic resonance，and clinical correlations[J].Arch Neurol，1985，42：951-959..
6. Meyer JS,Kawamura J,Terayama Y.White matter lesions in the elderly[J].J Neurol Sci,1992,110(1-2):1-7..
7. Pantoni L, Garcia JH.Pathogenesis of leukoaraiosis[J].Stroke，1997，28:652-659..
8. Wiszniewska M, Devuyst G, Bogousslavsky J,et al.What is the significance of leukoaraiosis in patients with acute ischemic stroke?[J]Arch Neurol，2000，57(7):967973.Comment in:Arch Neurol，2000，57(7):925-926..
9. de Leeuw FE, de Groot JC, Achten E,et al.Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study[J].J Neurol Neurosurg Psychiatry,2001,70(1):914.Comment in:J Neurol Neurosurg Psychiatry,2001,70(1):2-3.
10. de Leeuw FE,de Groot JC,Achten E,et al.Prevalence of cerebral white matter lesions in elderly people:a population based magnetic resonance imaging study.The Rotterdam Scan Study.
11. Ostrow PT, Miller LL.Pathology of small artery disease[J].Adv Neurol,1993,62:93-123..
12. Longstreth WT，Manollo TA，Arnold，et al.Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people[J].Stroke，1999，27(8)：12741282..
13. Baloh RW，Vinters HV.White matter lesions and disequibrium in older people：1 case contol comparison[J].Arch Neurol，1995，52：975-981..

West China Medical Journal

Initial Analysis of Correlation Factors of Leukoaraiosis

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