目的：评价低分子肝素(Low molecular weight heparins，LMWH)皮下注射持续时间对注射后皮下出血和疼痛的影响。方法：纳入2003年～2004年3月于我院行LMWH皮下注射的住院患者52例，以肚脐两侧作为注射点，任选一侧行首次注射，12 h后于另一侧以相同剂量注射。脐右注射持续10秒(对照组)，脐左持续30秒(实验组)。于注射后48 h、72 h观察注射点有无皮下出血，并用透明纸质毫米尺测量出血面积，用视觉类比量表(Visual analog scale，VAS)测量疼痛强度，记录疼痛持续时间。采用卡方检验及配对t检验对两组皮下出血发生率及面积、疼痛强度及持续时间等指标进行对比分析。结果：实验组和对照组皮下出血的发生率分别为38.5%(n=20)和61.5%(n=32)(P=0.035)。注射后48h、72h，实验组的出血面积均显著低于对照组(48h：17.5±7.3 mm2 VS 101.2±15.0 mm2，P=0.008；72h：20.7±8.0 mm2 VS 110.4±13.5 mm2，P=0.016)。实验组的注射后疼痛积分为13.0±6.4 mm，对照组为21.5±7.0 mm(P=0.021)。实验组疼痛持续时间显著低于对照组(42.5±14.2 s比73.2±20.0 s，P=0.030)。结论：肝素皮下注射持续时间能显著影响注射后皮下出血和疼痛形成，注射时间持续至30秒能有效降低皮下出血发生率及面积，并显著减轻疼痛强度、缩短疼痛时间。
Citation：
DENG Qianxi,LI Rongqiong,LI Xia. The Effect of the Duration of Subcutaneous Heparin Injection on Bruising and Pain. West China Medical Journal, 2009, 24(2): 300-302. doi:
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Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
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