Artifacts in CT-based Attenuation Correction Myocardial Perfusion SPECT：A Preliminary Study_West China Medical Journal

Authors：

LIU Bin , ZENG Yu ⁶¹⁰⁰⁴¹

Department of Nuclear Medicine，West China Hospital，Sichuan University，Chengdu 610041，China;

Corresponding author：

Keywords：

SPECT/CT; 心肌显像; MIBI; 衰减校正

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目的：研究心肌灌注显像（MPI）经CT衰减校正（CTAC）后伪影的产生及其对临床诊断的影响。方法：回顾性分析按Bayesian理论，冠心病患病率＜5%的48例受检者所行的72例次MPI（负荷41例次，静息31例次），图像在未行CTAC时显示正常者进行研究。将左心室心肌划分为20个节段，半定量分析（0分=放射性分布正常；1分=放射性分布轻度减低；2分=放射性分布中度降低；3分=放射性分布重度减低；4分=放射性分布缺损）各心肌节段在CTAC后放射性分布变化情况。结果：72例次MPI中，16例次（22.2%）的75个心肌节段（均在左心室心尖、前壁、前间壁区域）在CTAC后出现了放射性分布不同程度的减低。75个受累节段中分别有51、21和3个节段评分增加了1、2和3分，平均每个心肌节段评分增加了1.3分。41例次负荷MPI和31例次静息MPI中，分别有9例次（21.9%）的39个心肌节段、7例次（22.6%）的36个心肌节段在CTAC后出现了放射性分布减低，负荷与静息MPI相比，CTAC后发生心肌节段放射性分布减低的概率（χ2＝2.84，P＞0.05）与程度（u＝0.54，P＞0.05）均无显著统计学差异。10例负荷/静息MPI都满足纳入标准而纳入研究者中，4例的负荷/静息MPI在CTAC后，出现了相同部位（尖前壁、尖下壁）、相同程度（评分均增加了2分）的灌注降低；3例出现了同一部位，但不同程度的灌注减低；另有3例出现了不同部位心肌节段的灌注减低。CTAC后出现心肌节段灌注减低者与未出现者相比年龄、性别构成无统计学差异。结论：分析SPECT/CT心肌灌注图像时，应同时分析CTAC前后的灌注图像。对于只在CTAC后出现的灌注缺损，需要考虑可能存在CT与SPECT图像配位不准。

Citation： LIU Bin,ZENG Yu,Huang Rui,et al.. Artifacts in CT-based Attenuation Correction Myocardial Perfusion SPECT：A Preliminary Study. West China Medical Journal, 2009, 24(2): 388-391. doi: Copy

1.	Garcia EV.SPECT attenuation correction：An essential tool to realize nuclear cardiology’s mainfest destiny [J].J Nucl Cardiol，2007，14：16-21..
2.	Germano G，Slomka PJ，Berman DS.Attenuation correction in cardiac SPECT：the boy who cried wolf?[J]J Nucl Cardiol，2007，14：25-35..
3.	Diamond GA，Forester JS.Analysis of probability as an aid in the clinical diagnosis of coronary artery disease[J].N Engl J Med，1979，300：1350-1358..
4.	Port SC.Imaging guidelines for nuclear cardiology procedures[J].J Nucl Cardiol，1999，6：G67-G77..
5.	Klocke FJ，Baird MG，Lorell BH，et al.ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging[J].Circulation，2003，108：1404-1418..
6.	Gaemperli O，Schepis T，Valenta I，et al.Cardiac image fusion from standalone SPECT and CT：clinical experience[J].J Nucl Med，2007，48：696-703..
7.	Goetze S，Wahl R.Prevalence of misregistration between SPECT and CT for attenuationcorrected myocardial perfusion SPECT[J].J Nucl Car diol，2007，14：200-206.
8.	Fricke H，Fricke E，Weise R，et al.A method to remove artifacts in attenuation corrected myocardial perfusion SPECT introduced by misalignment between emission scan and CTderived attenuation maps[J].J Nucl Med，2004，45：1619-1625..
9.	Goetze S，Brown T，Lavely WC，et al.Attenuation corrected in myocardial perfusion SPECT/CT：effects of misregistration and value of reregistration[J].J Nucl Med，2007，48：10901095.
10.	Links Jm，Becker LC，Anstett F.Clinical significance of apical thinning after attenuation correction[J].J Nucl Cardiol，2004，11：26-31..
11.	Chen J，CaputluWilson SF，Shi HC，et al.Automated quality control of emissiontransmission misaligment for attenuation correction in myocardial perfusion imaging with SPECTCT systems[J].J Nucl Cardiol，2006，13：43-49..
12.	Heller GV，Links J，Bateman TM，et al.American Society of Nuclear Cardiology and Society of Nuclear Medicine Joint Statement：attenuation correction of myocardial perfusion SPECT scientigraphy[J].J Nucl Med，2004，45：229-230..

1. Garcia EV.SPECT attenuation correction：An essential tool to realize nuclear cardiology’s mainfest destiny [J].J Nucl Cardiol，2007，14：16-21..
2. Germano G，Slomka PJ，Berman DS.Attenuation correction in cardiac SPECT：the boy who cried wolf?[J]J Nucl Cardiol，2007，14：25-35..
3. Diamond GA，Forester JS.Analysis of probability as an aid in the clinical diagnosis of coronary artery disease[J].N Engl J Med，1979，300：1350-1358..
4. Port SC.Imaging guidelines for nuclear cardiology procedures[J].J Nucl Cardiol，1999，6：G67-G77..
5. Klocke FJ，Baird MG，Lorell BH，et al.ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging[J].Circulation，2003，108：1404-1418..
6. Gaemperli O，Schepis T，Valenta I，et al.Cardiac image fusion from standalone SPECT and CT：clinical experience[J].J Nucl Med，2007，48：696-703..
7. Goetze S，Wahl R.Prevalence of misregistration between SPECT and CT for attenuationcorrected myocardial perfusion SPECT[J].J Nucl Car diol，2007，14：200-206.
8. Fricke H，Fricke E，Weise R，et al.A method to remove artifacts in attenuation corrected myocardial perfusion SPECT introduced by misalignment between emission scan and CTderived attenuation maps[J].J Nucl Med，2004，45：1619-1625..
9. Goetze S，Brown T，Lavely WC，et al.Attenuation corrected in myocardial perfusion SPECT/CT：effects of misregistration and value of reregistration[J].J Nucl Med，2007，48：10901095.
10. Links Jm，Becker LC，Anstett F.Clinical significance of apical thinning after attenuation correction[J].J Nucl Cardiol，2004，11：26-31..
11. Chen J，CaputluWilson SF，Shi HC，et al.Automated quality control of emissiontransmission misaligment for attenuation correction in myocardial perfusion imaging with SPECTCT systems[J].J Nucl Cardiol，2006，13：43-49..
12. Heller GV，Links J，Bateman TM，et al.American Society of Nuclear Cardiology and Society of Nuclear Medicine Joint Statement：attenuation correction of myocardial perfusion SPECT scientigraphy[J].J Nucl Med，2004，45：229-230..

West China Medical Journal

Artifacts in CT-based Attenuation Correction Myocardial Perfusion SPECT：A Preliminary Study

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