The Observation on Efficacy of Moxifloxacin in Treating Primary Peritonitis in Patients with Cirrhosis_West China Medical Journal

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Department of Infectious Disease,General Hospital of Chengdu Military Command,Chengdu 610083,China;

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Keywords：

莫西沙星; 原发性腹膜炎; 肝硬化

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目的:观察莫西沙星治疗肝硬化并发原发性腹膜炎的疗效。方法:98例病例随机分成治疗组(51例)和对照组(47例),治疗组使用莫西沙星注射液400mg,静滴,1次 /天;对照组使用头孢哌酮/舒巴坦钠2g+左氧氟沙星注射液0.2g,静滴,2次/次,疗程7~10天。结果:治疗组总有效率为90.2%,明显高于对照组72.3%(P lt;0.05),并且能较快缓解患者感染的症状和体征,不良反应发生率仅为3.9%。结论:莫西沙星是治疗肝硬化并发原发性腹膜炎安全有效的药物

Citation： LI Xiaoan,CHEN Xianlan,HU Jian,et al. The Observation on Efficacy of Moxifloxacin in Treating Primary Peritonitis in Patients with Cirrhosis. West China Medical Journal, 2009, 24(3): 641-643. doi: Copy

1.	黎敏,李才,邓兴臣.肝硬化腹水合并自发性腹膜炎的临床分析和预后[J].中国社区医师,2006,8(143):66-67..
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3.	张锦前,杨玉英,吴亮,等.肝硬化合并自发性细菌性腹膜炎临床诊断标准及其病原分析[J].中国医师进修杂志,2006,29(4):47-49..
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5.	朱欣荣,潘云影.头孢噻肟钠联合左氧氟沙星治疗肝硬化并自发细菌性腹膜炎疗效观察[J].现代医药卫生,2008,24(17):2579-2580..
6.	陆颖,李宏力.莫西沙星注射液治疗急性细菌感染临床研究[J].中国现代医药杂志,2008,10(3):58-60..
7.	TORRES A,MUIR JF,CORRIS P,et al.Effectiveness of oral moxi?oxacin in standard ?rstline therapy in communityacquired pneumonia[J].Eur Respir J,2003,21(1):135-143..
8.	WILSON R,KUBIN R,BALLIN I,et al.Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis[J].Journal of Antimicrobial Chemotherapy,1999,44(4):501-513..
9.	STASS H,RINK A.D,DELESEN H,et al.Pharmacokinetics and peritoneal penetration of moxifloxacin in peritonitis[J].Journal of Antimicrobial Chemotherapy,2006,58(3):693-696..
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11.	王守义.肝硬化自发性细菌性腹膜炎的诊断和治疗[J].临床肝胆病杂志,2006,22(1):19-21..
12.	任小华,张郁馨,李晖.头孢三嗪和环丙沙星治疗慢性重型肝炎并发原发性腹膜炎疗效比较[J].四川医学,1999,20(1):24-25..
13.	谢维钊.左氧氟沙星治疗肝硬化腹水并发原发性腹膜炎的疗效观察[J].广东医学院学报,2001,19(5):365-366..
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15.	Llovet JM,Bartolí R,Planas R,et al.Bacterial translocation in cirrhotic rats.Its role in the development of spontaneous bacterial peritonitis[J].Gut,1994,35(11):1648-1652..
16.	张慧琳,吕晓菊,王其南,等.舒巴坦 头孢哌酮与头孢噻肟随机对照多中心临床研究[J].中国抗生素杂志,2001,26(4):274--280..
17.	肖永红,王进,赵彩云,等.2006-2007年Mohnarin细菌耐药监测[J].中华医院感染学杂志,2008,18(8):1051-1056..
18.	龙鑫,陈虹年,周清.头孢哌酮/舒巴坦治疗自发性细菌性腹膜炎疗效观察[J].现代医药卫生,2006,22(5):664..
19.	李庆兴,潘发愤,王邦松,等.第三代头孢菌素对4666株医院致病菌的耐药情况分析[J].中国微生态学杂志,2000,12(2):93-94..
20.	王进,李家泰,李耘.氟喹诺酮类抗菌药物对2554株细菌的抗菌活性分析[J].中国抗感染化疗杂志,2004,4(1):14-17..
21.	MALANGONI MA,SONG J,HERRINGTON J,et al.Randomized controlled trial of moxifloxacin compared with piperacillintazobactam and amoxicillinclavulanate for the treatment of complicated intraabdominal infections[J].Ann Surg,2006,244(2):204-211..
22.	章怡彬,刘明亮,郭慧元.新喹诺酮的结构特征及其对革兰阳性菌的构效关系[J].国外医药抗生素分册,2008,29(1):12-19..

1. 黎敏,李才,邓兴臣.肝硬化腹水合并自发性腹膜炎的临床分析和预后[J].中国社区医师,2006,8(143):66-67..
2. FIGUEIREDO FA,COELHO HS,SOARES JA.Spontaneous bacterial peritonitis in hepatic cirrhosis:prevalence,predictive factors and prognosis[J].Rev Assoc Med Bras,1999,45(2):128-136..
3. 张锦前,杨玉英,吴亮,等.肝硬化合并自发性细菌性腹膜炎临床诊断标准及其病原分析[J].中国医师进修杂志,2006,29(4):47-49..
4. 胡传芳.湖北地区腹水病人中常见细菌的分布及耐药性分析[J].湖北中医学院学报,2007,9(2):55-56..
5. 朱欣荣,潘云影.头孢噻肟钠联合左氧氟沙星治疗肝硬化并自发细菌性腹膜炎疗效观察[J].现代医药卫生,2008,24(17):2579-2580..
6. 陆颖,李宏力.莫西沙星注射液治疗急性细菌感染临床研究[J].中国现代医药杂志,2008,10(3):58-60..
7. TORRES A,MUIR JF,CORRIS P,et al.Effectiveness of oral moxi?oxacin in standard ?rstline therapy in communityacquired pneumonia[J].Eur Respir J,2003,21(1):135-143..
8. WILSON R,KUBIN R,BALLIN I,et al.Five day moxifloxacin therapy compared with 7 day clarithromycin therapy for the treatment of acute exacerbations of chronic bronchitis[J].Journal of Antimicrobial Chemotherapy,1999,44(4):501-513..
9. STASS H,RINK A.D,DELESEN H,et al.Pharmacokinetics and peritoneal penetration of moxifloxacin in peritonitis[J].Journal of Antimicrobial Chemotherapy,2006,58(3):693-696..
10. 中华医学会传染病与寄生虫病学会分会、肝病学分会.病毒性肝炎防治方案[J].中华传染病杂志,2001,19(1):56-62..
11. 王守义.肝硬化自发性细菌性腹膜炎的诊断和治疗[J].临床肝胆病杂志,2006,22(1):19-21..
12. 任小华,张郁馨,李晖.头孢三嗪和环丙沙星治疗慢性重型肝炎并发原发性腹膜炎疗效比较[J].四川医学,1999,20(1):24-25..
13. 谢维钊.左氧氟沙星治疗肝硬化腹水并发原发性腹膜炎的疗效观察[J].广东医学院学报,2001,19(5):365-366..
14. 张斌.肝硬化合并自发性细菌性腹膜炎发病机制研究进展[J].国外医学·生理、病理科学与临床分册,2003,23(1):103-105..
15. Llovet JM,Bartolí R,Planas R,et al.Bacterial translocation in cirrhotic rats.Its role in the development of spontaneous bacterial peritonitis[J].Gut,1994,35(11):1648-1652..
16. 张慧琳,吕晓菊,王其南,等.舒巴坦 头孢哌酮与头孢噻肟随机对照多中心临床研究[J].中国抗生素杂志,2001,26(4):274--280..
17. 肖永红,王进,赵彩云,等.2006-2007年Mohnarin细菌耐药监测[J].中华医院感染学杂志,2008,18(8):1051-1056..
18. 龙鑫,陈虹年,周清.头孢哌酮/舒巴坦治疗自发性细菌性腹膜炎疗效观察[J].现代医药卫生,2006,22(5):664..
19. 李庆兴,潘发愤,王邦松,等.第三代头孢菌素对4666株医院致病菌的耐药情况分析[J].中国微生态学杂志,2000,12(2):93-94..
20. 王进,李家泰,李耘.氟喹诺酮类抗菌药物对2554株细菌的抗菌活性分析[J].中国抗感染化疗杂志,2004,4(1):14-17..
21. MALANGONI MA,SONG J,HERRINGTON J,et al.Randomized controlled trial of moxifloxacin compared with piperacillintazobactam and amoxicillinclavulanate for the treatment of complicated intraabdominal infections[J].Ann Surg,2006,244(2):204-211..
22. 章怡彬,刘明亮,郭慧元.新喹诺酮的结构特征及其对革兰阳性菌的构效关系[J].国外医药抗生素分册,2008,29(1):12-19..

West China Medical Journal

The Observation on Efficacy of Moxifloxacin in Treating Primary Peritonitis in Patients with Cirrhosis

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