Clinical Aanalysis of 48 Patients with Primary Biliary Cirrhosis_West China Medical Journal

Authors：

ZEN Lingyong , HE Zhibing , YUAN Xiaoling

Department of Gastroenterology,the 3nd People’s Hospital of Neijiang,Neijiang Sichuan 641000,China;

Corresponding author：

Keywords：

原发性胆汁性肝硬化; 临床表现; 抗线粒体抗体

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目的:分析原发性胆汁性肝硬化(PBC)患者的临床表现,试验室检查及治疗情况。方法:回顾性分析48例PBC患者临床资料。结果:93.8%是中年女性患者,平均年龄53.2±8.73。主要的临床表现包括肝功能异常(ALT、GGT、AKP升高)95.8%,乏力纳差83.3%,黄疸79.2%,瘙痒66.6%,肝肿大62.5%,脾大58.3%等。常合并干燥综合征(25%),类风湿关节炎(16.7%)等自身免疫性疾病及结缔组织疾病。所以患者AMA及AMAM-2均为阳性。全部病例使用熊去氧胆酸治疗,但仅31.3%患者病情有不同程度好转。结论:加强对PBC的认识,重视对AMA 或AMA-M2的检测,尤其对长期不明原因肝功能异常的女性患者。

Citation： ZEN Lingyong,HE Zhibing,YUAN Xiaoling. Clinical Aanalysis of 48 Patients with Primary Biliary Cirrhosis. West China Medical Journal, 2009, 24(3): 649-650. doi: Copy

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West China Medical Journal

Clinical Aanalysis of 48 Patients with Primary Biliary Cirrhosis

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