Clinical Observation of Atorvastatin on Antirenal Oxidative Damage of Diabetic Nephropathy_West China Medical Journal

Authors：

1.Department of Nephrology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;2.Department of Endocrinogy,LongChang People’s Hosptial,Longchang 642150,China;

Corresponding author：

Keywords：

糖尿病肾病; 氧化应激; 阿托伐他汀

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目的:观察阿托伐他汀对抗糖尿病肾病患者肾氧化损伤作用。方法:56例糖尿病肾病患者随即分为对照组和阿托伐他汀组。对照组给予降糖、降压等治疗,阿托伐他汀组则在对照组治疗基础上加用阿托伐他汀10 mg/d,疗程共12周。检测两组患者治疗前后FBG、BUN、Scr、尿微量白蛋白以及血脂、血清SOD和MDA水平。结果:12周后两组患者FBG、BUN、Scr、尿微量白蛋白均较治疗前下降;与治疗前相比,阿托伐他汀组患者血脂水平较治疗前明显改善,同时患者血清SOD活性增,MDA含量下降,二者之间的差异具有显著性意义。结论:阿托伐他汀除具有降血脂作用外,还可改善糖尿病肾病患者的氧化应激状态。

Citation： LIAO Huawei,YANG Tingqiang,YAN Zhongxun,et al. Clinical Observation of Atorvastatin on Antirenal Oxidative Damage of Diabetic Nephropathy. West China Medical Journal, 2009, 24(3): 670-672. doi: Copy

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1.
2.
3. MARITIM AC,SANDERS RA,WAT KINS JB. Diabetes,oxidative stress,and antioxidants[J].Biochen Mol Toxicol,2003,17(1):24-38..
4. USNI H,SHIKATA K,MAT SUDA M,et al.HMGCoA reductase inhibitor ameliorates diabetic nephropat hy by its pleiotropic effects in rats[J].Nephrol Dial Transplant,2003,18(2):265272..
5. 于冬青,邓华聪,刘金波,辛伐他汀对糖尿病大鼠肾脏氧化应激的抑制作用[J].中国病理生理杂志,2006,22(4):824-825..
6. JONES SP,TESHIMA Y,AKAO M,et al.Simvastatin at tenuates oxidantinduced mitochondrial dysfunction in cardiac myocytes[J].Circ Res,2003,93(8):697-699..
7. 王雪艳,匡洪宇,糖尿病与糖尿病肾病患者氧化应激状态的分析[J].齐齐哈尔医学院学报,2008,29(6):694..
8. HENSLEY K,KOBINSON KA,GABBITA,et al.Reactive oxygen species,cell signaling,and cell injury[J].Free Radic Biol Med,2002,28(5):1456-1462..
9. GRAWEL S,WARDAS M,NIEDWOROK E,et al.Malondialdehyde(MDA)as a lipid peroxidation marker[J].Wiad Lek,2004,57(9-10):453-455..

West China Medical Journal

Clinical Observation of Atorvastatin on Antirenal Oxidative Damage of Diabetic Nephropathy

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