The Clinical observation of Benazepril Combined with Ginkgo Leaf Extract and Dipyridamole Injection on Early Diabetic Nephropathy_West China Medical Journal

Authors：

LIAO Xinli

Luhua Hospital of Luzhou City,Luzhou Sichuan 646000,China;

Corresponding author：

Keywords：

糖尿病肾病; 苯那普利; 银杏达莫注射液

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目的:观察苯那普利联合银杏达莫注射液对糖尿病肾病(DN)患者蛋白尿、肾功能以及血液流变学指标的影响。方法:75例2型糖尿病肾病患者随机分为对照组和治疗组,对照组给予饮食控制、降糖、降脂等常规治疗,对照组在常规治疗基础上给与苯那普利和银杏达莫注射液治疗,疗程共12周,分别观察治疗前后两组患者空腹血糖、血脂和肾功能以及UAER和血液流变学参数的变化。结果:治疗12周后,两组患者空腹血糖控制良好,治疗组患者UAER较对照组明显下降,分别为314.62±49.83 mL/min和282.97±36.62 mL/min,治疗组患者肾功能和血液流变学参数较治疗前明显改善(P lt;0.05)。结论:苯那普利联合银杏达莫注射液能明显改善糖尿病肾病患者血液流变学参数,提高肾脏功能,减少24 h尿蛋白。

Citation： LIAO Xinli. The Clinical observation of Benazepril Combined with Ginkgo Leaf Extract and Dipyridamole Injection on Early Diabetic Nephropathy. West China Medical Journal, 2009, 24(3): 673-675. doi: Copy

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2.	REMIUZZI G,RUGGENENTI P,PERNA A,et al.Continuum of renoprotection with losartan at all stages of type 2 diabetic nephropathy:a post hoc analysis of the RENAAL trial results[J].J Am Soc Nephrol,2004,15(12):3117-3125..
3.	RAYMOND OE,JOSEPH RC,ZUNG VT,et al.Effect of Intensive Blood Pressure Control With Valsartan on Urinary Albumin Excretion in Normotensive Patients With Type 2 Diabetes[J].Am J Hypertension,2006,19(12):1241-1248..
4.	SCHRIER RW,ESTACIO RO,ESLER A,et al.Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria,retinopathy and strokes.Clinical NephrologyEpidemiologyClinical Trials[J].Kidney International,2002,61(3):1086-1097..
5.	陈雅静.Ⅳ型胶原酶与糖尿病肾病[J].国外医学·内分泌学分册,2002,22(4):256-258..
6.	KOYA D,KING G L.Protein kinase C activation and the development of diabetic complications [J].Diabetes,1998,47:859-866..
7.	翟文杰,李爱群.中西医结合洽疗早期糖尿病肾病68例观察[J].中西医结合,2006,35(9):106..

1. 周希静.糖尿病肾病的治疗进展[J].中国中西医结合肾病杂志,2003,4(10):559-560..
2. REMIUZZI G,RUGGENENTI P,PERNA A,et al.Continuum of renoprotection with losartan at all stages of type 2 diabetic nephropathy:a post hoc analysis of the RENAAL trial results[J].J Am Soc Nephrol,2004,15(12):3117-3125..
3. RAYMOND OE,JOSEPH RC,ZUNG VT,et al.Effect of Intensive Blood Pressure Control With Valsartan on Urinary Albumin Excretion in Normotensive Patients With Type 2 Diabetes[J].Am J Hypertension,2006,19(12):1241-1248..
4. SCHRIER RW,ESTACIO RO,ESLER A,et al.Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria,retinopathy and strokes.Clinical NephrologyEpidemiologyClinical Trials[J].Kidney International,2002,61(3):1086-1097..
5. 陈雅静.Ⅳ型胶原酶与糖尿病肾病[J].国外医学·内分泌学分册,2002,22(4):256-258..
6. KOYA D,KING G L.Protein kinase C activation and the development of diabetic complications [J].Diabetes,1998,47:859-866..
7. 翟文杰,李爱群.中西医结合洽疗早期糖尿病肾病68例观察[J].中西医结合,2006,35(9):106..

West China Medical Journal

The Clinical observation of Benazepril Combined with Ginkgo Leaf Extract and Dipyridamole Injection on Early Diabetic Nephropathy

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