目的:探讨基因重组人生长激素(recombinant human growth hormone, rhGH)对特发性矮小儿童促身高增长的疗效。方法:ISS儿童60例,每晚睡前接受rhGH治疗0.15～0.18 IU/(kg·d),疗程3～9个月,并对其疗效进行观察。结果:ISS患儿经生长激素治疗后,生长速率明显增快,由治疗前4.21±0.36 cm/年提高到治疗后8.29±4.72 cm/年,差异有显著性(P lt;0.05)。而骨龄和体重无明显变化,差异不显著(P gt;0.05)。治疗期间除少数肝功能轻度异常,注射部位轻度反应外,未发现明显副作用。结论:rhGH对ISS儿童有增快生长速度作用。
Citation：
WU Jin,XIANG Chengfa,LEI Mingyu,et al. The Study of Therapeutic Effect of Recombinant Human Growth Hormone in Children with Idiopathic Short Stature. West China Medical Journal, 2009, 24(4): 856-857. doi:
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- 1. 吴瑾,向承发,王栋.1038例矮小症病因及治疗的研究[J].中国妇幼保健,2008,(7):947-950..
- 2. 刘戈力.特发性身材矮小[J].中国实用儿科杂志,2005,20(8):453-455..
- 3. 黄晓萍,王伟.儿童特发性矮小临床治疗新进展[J].临床儿科杂志,2008,26(5):438-442..
- 4. WILSON T A, ROSE S R, COHEN P, et al. Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee [J]. J Pediatr,2003,143(4):415-421..
- 5. 吴瑾,向承发,孙小妹,等.重组人生长激素治疗特纳氏综合征临床观察[J].四川医学,2008,(7):881-882..
- 6. KEMP SF, KUNTZE J, ATTIE KM, et al. Efficacy and safety results of long-term growth hormone treatment of idiopathic short stature [J]. J Clin Endocrinol Metab,2005,90(9):5247-5253..
