The Study of Expression of P53 Protein in Basal Cell Carcinoma_West China Medical Journal

Authors：

CAO Mei , HE Yanling , TIAN Yongjing

Departmrnt of Dermatology, Beijing Chaoyang Hospital Affiliated to the Capital University of Medical Sciences, Beijing 100020, China;

Corresponding author：

Keywords：

基底细胞癌; P53

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目的:分析基底细胞癌中P53蛋白的表达情况,探讨P53蛋白的表达与基底细胞癌发生发展的关系,以及在基底细胞癌发病机制中的作用。方法:选取2006年7月至2007年2月,北京朝阳医院皮肤科手术切除的基底细胞癌及正常皮肤组织石蜡标本各17例,免疫组织化学法分析P53蛋白在基底细胞癌和正常皮肤组织中的表达情况。结果:17例基底细胞癌中P53蛋白的表达率为100%。综合染色强度和阳性细胞所占比例进行平均半定量分析,P53蛋白在基底细胞癌中表达程度为,而在正常皮肤组织中表达程度为+,两者之间存在统计学上显著性差异。结论:P53在基底细胞癌中呈现高度表达状态,提示P53蛋白的表达与基底细胞癌的发病过程关系密切,可能在其发生发展过程中起重要作用。

Citation： CAO Mei,HE Yanling,TIAN Yongjing. The Study of Expression of P53 Protein in Basal Cell Carcinoma. West China Medical Journal, 2009, 24(4): 858-860. doi: Copy

1.	 MOSNIER J F, PERRET A G, VINDIMIAN M, et al. An immunohistochermical study of the simultaneous expression of bcl-2 and p53 oncoproteins in epithelial tumor of the colon and rectum[J]. Arch Pathol Lab Med,1996,120(7):654..
2.	SHEA C R, MC NATT N S, VOLKENANDT M. Overexpression of p53 protein in basal cell carcinomas of human skin[J]. Am J Pathol,1992,141:25..
3.	DEROSA G, STAIBANO S, BARRA E, P53 protein inaggressive and non-aggressive basal cell carcinoma[J]. J Cutan Pathol,1993,20:429..
4.	RO YS,COOPER PN,LEE JL.P53 protein expression in benign and malignant skin tumours[J].Br J Dermatol,1993,128:237..
5.	肖绍文,颜博,吕有勇,等.野生型p53基因转染对胃癌细胞的作用[J].中国血液流变学杂志,2006,16(1):4-6..
6.	肖绍文,张珊文,吕有勇,等.外源性p53基因对人胃癌细胞的放射增敏作用[J].北京大学学报(医学版),2001,33(5):427-431..
7.	张珊文,肖绍文,吕有勇.腺病毒介导p53基因对人胃癌细胞热增敏作用[J].中华物理学与康复杂志,2002,24(8):489-492..
8.	张珊文,肖绍文,刘长青,等.头颈鳞癌基因治疗结合放疗的临床研究[J].中华肿瘤杂志,2005,27(7):426-427..
9.	SWISHER S G, ROTH J A, KAMAKI R, et al.Induction of p53 regulated genes and tumor regre- ssion in lung cancer patients after intratumoral delivery of adenoviral p53(NGN 201) and radiation therapy[J].Clin Cancer Res,2003,9(1):93-101.

1.  MOSNIER J F, PERRET A G, VINDIMIAN M, et al. An immunohistochermical study of the simultaneous expression of bcl-2 and p53 oncoproteins in epithelial tumor of the colon and rectum[J]. Arch Pathol Lab Med,1996,120(7):654..
2. SHEA C R, MC NATT N S, VOLKENANDT M. Overexpression of p53 protein in basal cell carcinomas of human skin[J]. Am J Pathol,1992,141:25..
3. DEROSA G, STAIBANO S, BARRA E, P53 protein inaggressive and non-aggressive basal cell carcinoma[J]. J Cutan Pathol,1993,20:429..
4. RO YS,COOPER PN,LEE JL.P53 protein expression in benign and malignant skin tumours[J].Br J Dermatol,1993,128:237..
5. 肖绍文,颜博,吕有勇,等.野生型p53基因转染对胃癌细胞的作用[J].中国血液流变学杂志,2006,16(1):4-6..
6. 肖绍文,张珊文,吕有勇,等.外源性p53基因对人胃癌细胞的放射增敏作用[J].北京大学学报(医学版),2001,33(5):427-431..
7. 张珊文,肖绍文,吕有勇.腺病毒介导p53基因对人胃癌细胞热增敏作用[J].中华物理学与康复杂志,2002,24(8):489-492..
8. 张珊文,肖绍文,刘长青,等.头颈鳞癌基因治疗结合放疗的临床研究[J].中华肿瘤杂志,2005,27(7):426-427..
9. SWISHER S G, ROTH J A, KAMAKI R, et al.Induction of p53 regulated genes and tumor regre- ssion in lung cancer patients after intratumoral delivery of adenoviral p53(NGN 201) and radiation therapy[J].Clin Cancer Res,2003,9(1):93-101.

West China Medical Journal

The Study of Expression of P53 Protein in Basal Cell Carcinoma

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