Investigation of the Carotid Atherosclerosis in Elderly Patients_West China Medical Journal

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Department of Geriatics,West China Hospital,Sichuan University,Chengdu 610041,China;

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Keywords：

颈动脉粥样硬化; 老年人; 颈动脉内中膜厚度; 颈动脉斑块

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目的:探讨老年人颈动脉粥样硬化临床特点及其相关危险因素。方法:收集符合纳入标准的住院老年患者临床资料,颈动脉多普勒检测颈总动脉内中膜厚度(IMT)、斑块有无及性质、管腔狭窄程度。结果:(1)老年人群颈总动脉IMT异常者占50.53％;颈动脉斑块阳性者占78.7％;颈动脉狭窄者占20％,以轻度狭窄为主。(2)颈动脉斑块好发部位依次是左颈总分叉、左颈总动脉、右颈总动脉、右颈总分叉、颈动脉窦、左颈内动脉、右颈内动脉、右颈外动脉、左颈外动脉。(3)颈动脉斑块阳性人群合并高血压心肌梗塞脑血管意外和心脑血管事件率增加。(4)颈动脉IMT异常组较IMT正常组年龄、收缩压、甘油三酯,合并脑血管事件和心脑血管事件明显增加,同时颈总动脉IMT增厚伴颈动脉斑块阳性率、管腔狭窄率及斑块累及部位增加。结论:老年患者颈动脉粥样硬化的发病率高,斑块好发于颈动脉分叉、颈总动脉、颈内动脉,并以左侧常见。颈总动脉IMT异常组合并脑血管事件和心脑血管事件率明显增加,颈总动脉IMT增厚增加颈动脉斑块和管腔狭窄的发生率。

Citation： JIANG Aixia,DING Qunfang,LUO Fang,et al. Investigation of the Carotid Atherosclerosis in Elderly Patients. West China Medical Journal, 2009, 24(4): 881-884. doi: Copy

1.	PJ TOUBOUL, MG HENNERICI, S MEAIRS, et al.Mannheim Carotid Intima-Medi Thickness Consensus(2004-2006)[J].Cerebrovasc Dis,2007,23:75-80..
2.	EJ LEE, HJ KIM, JM BAE, et al.Relevance of Common Carotid Intima-Media Thickness and Carotid Plaque as Risk Factors for Ischemic Stroke in Patients with Type 2 DiabetesMellitus[J].Am J Neuroradiol,2007,28:916-19..
3.	PATRICK J DEVINE, DANIEL W CARLSON, et al. Clinical value of carotid intima-media thickness testing[J].J Nucl Cardiol,2006,13:710-8..
4.	RONGLING LI, BRUCE B DUNCAN, PATRICIA A METCALF, et al. B-Mode-Detected Carotid Artery Plaque in a General Population[J].Stroke,1994,25:2377-2383..
5.	ROSFORS S, STEM S H, RERSTIN J U, et al. Relationship between intima- media thickness in the common carotid artery and atherosclerosis in the carotid bifurcation[J].Stroke,1998,29(7):1378-1382..
6.	MARY J ROMAN, TASNEEM Z NAQVI, JULIUS M GARDIN, et al. American Society of Echocardiography Report Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification:a report from the American Society of Echocardiography and the Society for Vascular Medicine and Biology[J].Vascular Medicine,2006,11:201-211..
7.	ROMAN KOMOROVSKY, ALESSANDRO DESIDERI, et al. Carotid ultrasound assessment of patients with coronary artery disease:a useful index for risk stratification[J].Vascular Health and Risk Management,2005,1(2):131-136..
8.	AKIHIKO KITAMURA, HIROYASU ISO, HIRONORI IMANO, et al. Carotid Intima-Media Thickness and Plaque Characteristics as a Risk Factor for Stroke in Japanese Elderly Men[J].Stroke,2004,35:2788-2794.
9.	JIE J CAO, ALICE, ARNOLD, et al. Association of Carotid Artery Intima-Media Thickness,Plaques,and C-Reactive Protein With Future Cardiovascular Disease and All-Cause Mortality The Cardiovascular Health Study[J].Circulation,2007,116:32-38.
10.	YOSHIHIRO SEO, SHIGEYUKI WATANABE, TOMOKO ISHIZU, et al. Echolucent Carotid Plaques as a Feature in Patients With Acute Coronary Syndrome[J].Circ J,2006,70:1629-1634..
11.	LLOYD E CHAMBLESS, GERARDO HEISS, AARON R FOLSOM. Association of Coronary Heart Disease Incidence with Carotid Arterial Wall Thickness and Major Risk Factors:The Atherosclerosis Risk in Communities(ARIC)Study,1987-1993[J].Am J Epidemiol,1997,146:483-94..
12.	ANNE B NEWMAN, BARBARA L NAYDECK, DIANE G IVES, et al. Coronary Artery Calcium,Carotid Artery Wall Thickness and Cardiovascular Disease Outcomes in Adults 70 to 99 Years Old[J].Am J Cardiol.2008,101(2):186-192.

1. PJ TOUBOUL, MG HENNERICI, S MEAIRS, et al.Mannheim Carotid Intima-Medi Thickness Consensus(2004-2006)[J].Cerebrovasc Dis,2007,23:75-80..
2. EJ LEE, HJ KIM, JM BAE, et al.Relevance of Common Carotid Intima-Media Thickness and Carotid Plaque as Risk Factors for Ischemic Stroke in Patients with Type 2 DiabetesMellitus[J].Am J Neuroradiol,2007,28:916-19..
3. PATRICK J DEVINE, DANIEL W CARLSON, et al. Clinical value of carotid intima-media thickness testing[J].J Nucl Cardiol,2006,13:710-8..
4. RONGLING LI, BRUCE B DUNCAN, PATRICIA A METCALF, et al. B-Mode-Detected Carotid Artery Plaque in a General Population[J].Stroke,1994,25:2377-2383..
5. ROSFORS S, STEM S H, RERSTIN J U, et al. Relationship between intima- media thickness in the common carotid artery and atherosclerosis in the carotid bifurcation[J].Stroke,1998,29(7):1378-1382..
6. MARY J ROMAN, TASNEEM Z NAQVI, JULIUS M GARDIN, et al. American Society of Echocardiography Report Clinical application of noninvasive vascular ultrasound in cardiovascular risk stratification:a report from the American Society of Echocardiography and the Society for Vascular Medicine and Biology[J].Vascular Medicine,2006,11:201-211..
7. ROMAN KOMOROVSKY, ALESSANDRO DESIDERI, et al. Carotid ultrasound assessment of patients with coronary artery disease:a useful index for risk stratification[J].Vascular Health and Risk Management,2005,1(2):131-136..
8. AKIHIKO KITAMURA, HIROYASU ISO, HIRONORI IMANO, et al. Carotid Intima-Media Thickness and Plaque Characteristics as a Risk Factor for Stroke in Japanese Elderly Men[J].Stroke,2004,35:2788-2794.
9. JIE J CAO, ALICE, ARNOLD, et al. Association of Carotid Artery Intima-Media Thickness,Plaques,and C-Reactive Protein With Future Cardiovascular Disease and All-Cause Mortality The Cardiovascular Health Study[J].Circulation,2007,116:32-38.
10. YOSHIHIRO SEO, SHIGEYUKI WATANABE, TOMOKO ISHIZU, et al. Echolucent Carotid Plaques as a Feature in Patients With Acute Coronary Syndrome[J].Circ J,2006,70:1629-1634..
11. LLOYD E CHAMBLESS, GERARDO HEISS, AARON R FOLSOM. Association of Coronary Heart Disease Incidence with Carotid Arterial Wall Thickness and Major Risk Factors:The Atherosclerosis Risk in Communities(ARIC)Study,1987-1993[J].Am J Epidemiol,1997,146:483-94..
12. ANNE B NEWMAN, BARBARA L NAYDECK, DIANE G IVES, et al. Coronary Artery Calcium,Carotid Artery Wall Thickness and Cardiovascular Disease Outcomes in Adults 70 to 99 Years Old[J].Am J Cardiol.2008,101(2):186-192.

West China Medical Journal

Investigation of the Carotid Atherosclerosis in Elderly Patients

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