Comparison of Effect of Two Common First-line Triple Therapies on Helicobacter Pylori Infection_West China Medical Journal

Authors：

SI Ke , LIAO Wen

Department of Gastroenterology, the First Hospital, Chengdu Sichuan 610041, China;

Corresponding author：

Keywords：

幽门螺杆菌; 根除; 三联; 疗效

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目的:观察两种常用一线根除幽门螺杆菌(H.pylori)三联方案在本地区(成都市)的疗效。方法:纳入70例诊断为消化性溃疡、慢性糜烂性胃炎、慢性萎缩性胃炎伴H.pylori感染的患者。随机分为A、B两组。A组采用埃索美拉唑(E)20 mg bid+克拉霉素(C)500 mg bid+甲硝唑(M)400 mg bid,B组采用E 20 mg bid+ C 500 mg bid+阿莫西林(A)1.0g bid治疗,疗程7天。H.pylori根除失败者以1周四联方案:E 20 mg bid+胶体次枸櫞酸铋(B)220 mg bid+呋喃唑酮100 mg bid+ A1.0g bid治疗,观察疗效。结果:64例完成实验。三联方案H.pylori根除率:A组62.5%,B组84.4%,有显著差异(P lt;0.05)。二线四联方案根除率94.1%。结论:ECA方案H.pylori根除率明显高于ECM方案,可能更适合于本地区根除H.pylori的一线治疗,EBFA方案作为二线治疗具有较高疗效。

Citation： SI Ke,LIAO Wen. Comparison of Effect of Two Common First-line Triple Therapies on Helicobacter Pylori Infection. West China Medical Journal, 2009, 24(4): 896-898. doi: Copy

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1. MALFERTHEINER P, MEGRAND F, O’MORAIN, et al. Current concepts in the management of Helicobacter pylori infection: the MaastrichtⅢconsensus Report[J].Gut, 2007,56(6):722-781..
2. 刘文忠. 质子泵的临床应用[M]∥许国铭,钟捷主编. 质子泵抑制剂-基础与临床. 上海:上海科技教育出版社,2004: 42..
3. FURUTA T, OHASHI K, KOSUGE K, et al. CYP2C19 genotype status and effect of omeprazole on intragastric pH in humans[J]. Clin Pharmacol Ther,1999, 65:552-561..
4. ANDERSSON T, HASSAN-ALIN M, HASSELGREN G, et al. Pharmacokinetic studies with esomeprazole,the (S)-isomer of omeprazole[J].Clin Pharmacokinet, 2001,40:411-426..
5. MEGRAUD F H. Pylori antibiotic resistance: prevalence, importance, and advances in testing[J]. Gut, 2004,53:1374-1384..
6. CHINESE H. Pylori Study Group. Development in research on resistance of H. Pylori to antibiotics[C]. The 5th Korea-Japan-China Joint Conference on H. Pylori Abstracts 2006:20, 23..
7. 成虹,胡伏莲. 北京地区幽门螺杆菌耐药情况及其变化趋势[J]. 中华医学杂志,2005,85:2754-2757..

West China Medical Journal

Comparison of Effect of Two Common First-line Triple Therapies on Helicobacter Pylori Infection

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