Analysis of Paraoxonase 1 Activity in the Patients with Hyperhyroidism_West China Medical Journal

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Department of Laboratory, The Affiliated Hostital of North Sichuan Medical College, Nanchong, 637000,China;

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Keywords：

甲状腺功能亢进症; 对氧磷酯酶1; 丙二醛; 超氧化物歧化酶

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目的:探讨甲状腺功能亢进症(甲亢)患者血浆对氧磷酯酶1(PON1)活性变化以及与其它氧化应激指标的关系。方法:分别测定50名对照组和78例甲亢组空腹血浆中游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、PON1活性、超氧化物歧化酶(SOD)、丙二醛(MAD)、氧化低密度脂蛋白(ox-LDL)及血脂含量,并进行相关性分析。结果:甲亢患者血浆PON1活性(139 ±64)kU/L,ox-LDL(598.3±58.6)μg/L,MDA(15.11±3.26) μmol/L及SOD(80.2±25.3)NU/mL。对照组上述指标分别为:PON1(168 ±70)kU/L,ox-LDL (446.2±62.2) μg/L,MDA (10.02±3.00) μmol/L,SOD(92.9±26.9)NU/mL。血浆PON1和SOD活性显著低于对照组(P lt;0.01),ox-LDL和MDA水平显著高于对照组(P lt;0.01)。甲亢患者血浆PON1活性与SOD呈正相关(r=0. 381,P lt; 0.05),与ox-LDL、MDA呈负相关(r=-0. 411,r=-0. 445,P lt; 0.01)。结论:甲亢患者血浆PON1活性显著降低,可能与氧化应激增强有关。

Citation： JIANG Xingliang,FAN Quming,ZHANG Xiaolan,et al. Analysis of Paraoxonase 1 Activity in the Patients with Hyperhyroidism. West China Medical Journal, 2009, 24(4): 902-904. doi: Copy

1.	COSTANTINI F, PIERDOMENICO S D, CESARE D D, et al. Effect of thyroid function on LDL oxidation[J]. Arterioscler Thromb Vasc Biol,1998, 18:732-737..
2.	DRRINGTON P N, MACKNESS B, MACKNESS M I. Paraoxonase and therosclerosis[J]. Arterioscler Thromb Vasc Biol, 2001, 21: 473-480..
3.	TSUZURA S, IKEDA Y, SUEHIRO T, et al. Correlation of plasma oxidized low-density lipoprotein levels to vascular complications and human serum paraoxonase in patients with type 2 diabetes[J]. Metabolism, 2004, 53(3):297-302..
4.	MACKNESS M, HARTY D, BHATNAGAR D, et al. Serum paraoxonase activity in familial hypercholesterolemia and insulin-dependent diabetes mellitus[J]. Atherosclerosis,1991, 86:193-199..
5.	蒋兴亮, 周京国, 唐中. 脑梗死患者血浆对氧磷酯酶-1与氧化低密度脂蛋白水平的变化及意义[J]. 中国老年学杂志,2005,25(9):1026-1027..
6.	FERRE N, CAMPS J, PRATS E, et al.Serum paraoxonase activity: a new additional test for the improved evaluation of chronic liver damage[J]. Clin Chem, 2002, 48(1):261-268..
7.	PEREIRA B, ROSA LF, SAFI, et al. Control of superoxide dismutase, catalase and glutathione peroxidase activities in rat lymphoid organs by thyroid hormones. J Endocrinol,1994, 140: 73-77..
8.	RAISZADEH F, SOLATI M, ETEMADI A, et al. Serum paraoxonase activity before and after treatment of thyrotoxicosis[J]. Clinical Endocrinology, 2004, 60: 75-80..
9.	AZIZI F, RAISZADEH F, SOLATI M, et al. Serum paraoxonase 1 activity is decreased in thyroid dysfuncyion[J]. J Endocrinol Invest, 2003, 26:703-709..
10.	AVIRAM M, ROSENBLAT M, BILLEKE S, et al. Human serum paraoxonase (PON1) is inactiviated by oxidized low density lipoprotein and preserved by antioxidants[J]. Free Radic Biol Med,1999,26:892-904..
11.	OZATA M, YILDIRIMKAYA M, YILMAZ K, et al. The effects of thyroid status on serum apolipoprotein A-I-containing lipoprotein particles[J]. Hormone and Metabolic Research,1998,30: 217-221..
12.	DUNTAS L, MANTZOU E, KOUTRAS DA. Circulating levels of oxidized low-density lipoprotein in overt and mild hypothyroidism. Thyroid, 2002, 12:1003-1007.

1. COSTANTINI F, PIERDOMENICO S D, CESARE D D, et al. Effect of thyroid function on LDL oxidation[J]. Arterioscler Thromb Vasc Biol,1998, 18:732-737..
2. DRRINGTON P N, MACKNESS B, MACKNESS M I. Paraoxonase and therosclerosis[J]. Arterioscler Thromb Vasc Biol, 2001, 21: 473-480..
3. TSUZURA S, IKEDA Y, SUEHIRO T, et al. Correlation of plasma oxidized low-density lipoprotein levels to vascular complications and human serum paraoxonase in patients with type 2 diabetes[J]. Metabolism, 2004, 53(3):297-302..
4. MACKNESS M, HARTY D, BHATNAGAR D, et al. Serum paraoxonase activity in familial hypercholesterolemia and insulin-dependent diabetes mellitus[J]. Atherosclerosis,1991, 86:193-199..
5. 蒋兴亮, 周京国, 唐中. 脑梗死患者血浆对氧磷酯酶-1与氧化低密度脂蛋白水平的变化及意义[J]. 中国老年学杂志,2005,25(9):1026-1027..
6. FERRE N, CAMPS J, PRATS E, et al.Serum paraoxonase activity: a new additional test for the improved evaluation of chronic liver damage[J]. Clin Chem, 2002, 48(1):261-268..
7. PEREIRA B, ROSA LF, SAFI, et al. Control of superoxide dismutase, catalase and glutathione peroxidase activities in rat lymphoid organs by thyroid hormones. J Endocrinol,1994, 140: 73-77..
8. RAISZADEH F, SOLATI M, ETEMADI A, et al. Serum paraoxonase activity before and after treatment of thyrotoxicosis[J]. Clinical Endocrinology, 2004, 60: 75-80..
9. AZIZI F, RAISZADEH F, SOLATI M, et al. Serum paraoxonase 1 activity is decreased in thyroid dysfuncyion[J]. J Endocrinol Invest, 2003, 26:703-709..
10. AVIRAM M, ROSENBLAT M, BILLEKE S, et al. Human serum paraoxonase (PON1) is inactiviated by oxidized low density lipoprotein and preserved by antioxidants[J]. Free Radic Biol Med,1999,26:892-904..
11. OZATA M, YILDIRIMKAYA M, YILMAZ K, et al. The effects of thyroid status on serum apolipoprotein A-I-containing lipoprotein particles[J]. Hormone and Metabolic Research,1998,30: 217-221..
12. DUNTAS L, MANTZOU E, KOUTRAS DA. Circulating levels of oxidized low-density lipoprotein in overt and mild hypothyroidism. Thyroid, 2002, 12:1003-1007.

West China Medical Journal

Analysis of Paraoxonase 1 Activity in the Patients with Hyperhyroidism

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