参附注射液对行颅内动脉瘤夹闭术患者血清SOD,MDA,S-100β 蛋白的影响_West China Medical Journal

Authors：

张璟瑜 , 唐作磊 , 纳雪晴 , 李羽

Corresponding author：

Keywords：

参附注射液; 动脉瘤; MDA; SOD; S-100β

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的:观察参附注射液对行颅内动脉瘤夹闭术患者MDA,SOD,S-100β蛋白(S-100β)的影响,以探讨其脑保护的机制。方法:行颅内动脉瘤夹闭术患者随机分为参附组(Ⅰ组)和对照组(Ⅱ组),分别于术前12 h和手术日麻醉诱导前30 min给予参附注射液 1 mL/kg和生理盐水1 mL/kg,在于气管插管后即刻T1, 夹闭动脉瘤前T2,动脉瘤夹闭后30 min T3,分别缓慢抽取颈内静脉球部血样5 mL以备检测SOD活性和MDA,S-100β的含量。结果:参附组(Ⅰ组)MDA和S-100β含量明显低于对照组(Ⅱ组),P lt;0.05,SOD活性明显高于对照组(Ⅱ组), P lt;0.05。结论:参附注射液可提高SOD活性,降低MDA和S-100β的含量,从而对行颅内动脉瘤夹闭术患者有脑保护作用。

Citation： 张璟瑜,唐作磊,纳雪晴,李羽. 参附注射液对行颅内动脉瘤夹闭术患者血清SOD,MDA,S-100β 蛋白的影响. West China Medical Journal, 2009, 24(4): 975-977. doi: Copy

1.	朱正华,熊利泽,董海龙,等.参附注射液对大鼠短暂性局灶性脑缺血损伤的保护作用[J]. 中国中西医结合急救杂志,2001,8(2):79..
2.	郑玉,熊利泽,朱正华,等.参附注射液对大鼠短暂性局灶性脑缺血损伤的治疗时间窗[J]. 第四军医大学学报,2002,23(15):1353..
3.	朱正华,熊利泽,董海龙,等.参附注射液对兔脊髓缺血损伤的保护作用[J]. 第四军医大学学报,2000,21(3):278..
4.	王尧,杜子威.神经生物化学分子生物学[M].北京:人民卫生出版社,1997:390-399..
5.	JARASCH E D, BRUDER G, HEI H V, et al. Singnificance of xanthine oxidase in capillary endothelialcell[J]. Acta Pysiol Scand Suppl,1986,548:39..
6.	BLECH D M, BORDERS C L J R. Hydroperoxide anion,Ho-2,is an affinity reagent for the inactiveation of yeast Ca/Zn superoxide dismutase modification of one histidene perubunit[J]. Arch Biochem Biochem Biophys,1983,224(2):579..
7.	毛伯镛,张跃康,等.动脉瘤术后血管痉挛的综合治疗(附284例报告)[J].中国侵袭神经外科杂志,2004,9(2):53-56..
8.	甘国胜,余剑波,等.丙泊酚麻醉对急性颅脑外伤手术患者血清S-100β 的影响[J].临床麻醉学杂志,2005,12(21):811-812..
9.	ANDEERSON R E, HANSSON L O, NILSSON O, et al . High serum S-100β levels for trauma patients wit hout head injuries[J]. Neurosurgery,2001,48:12552158.〖ZK)〗.
10.	WUNDERLICH, MICHAEL T, MD EBERT, et al. Early Neurobehavioral Outcome After Stroke Is Related to Release of Neurobiochemical Markers of Brain Damage [J]. Stroke,1999,30(6):1190-1195..
11.	陈烧洋,熊利泽,曾祥龙,等.麻醉和手术中脑氧供需平衡研究进展[J]. 解放军医学杂志,2002,27(2):187..
12.	孙海云,黄品婕,等.参附注射液对全麻气管插管应激反应的影响[J]. 海南医学,2005,16(12):66-67..

1. 朱正华,熊利泽,董海龙,等.参附注射液对大鼠短暂性局灶性脑缺血损伤的保护作用[J]. 中国中西医结合急救杂志,2001,8(2):79..
2. 郑玉,熊利泽,朱正华,等.参附注射液对大鼠短暂性局灶性脑缺血损伤的治疗时间窗[J]. 第四军医大学学报,2002,23(15):1353..
3. 朱正华,熊利泽,董海龙,等.参附注射液对兔脊髓缺血损伤的保护作用[J]. 第四军医大学学报,2000,21(3):278..
4. 王尧,杜子威.神经生物化学分子生物学[M].北京:人民卫生出版社,1997:390-399..
5. JARASCH E D, BRUDER G, HEI H V, et al. Singnificance of xanthine oxidase in capillary endothelialcell[J]. Acta Pysiol Scand Suppl,1986,548:39..
6. BLECH D M, BORDERS C L J R. Hydroperoxide anion,Ho-2,is an affinity reagent for the inactiveation of yeast Ca/Zn superoxide dismutase modification of one histidene perubunit[J]. Arch Biochem Biochem Biophys,1983,224(2):579..
7. 毛伯镛,张跃康,等.动脉瘤术后血管痉挛的综合治疗(附284例报告)[J].中国侵袭神经外科杂志,2004,9(2):53-56..
8. 甘国胜,余剑波,等.丙泊酚麻醉对急性颅脑外伤手术患者血清S-100β 的影响[J].临床麻醉学杂志,2005,12(21):811-812..
9. ANDEERSON R E, HANSSON L O, NILSSON O, et al . High serum S-100β levels for trauma patients wit hout head injuries[J]. Neurosurgery,2001,48:12552158.〖ZK)〗.
10. WUNDERLICH, MICHAEL T, MD EBERT, et al. Early Neurobehavioral Outcome After Stroke Is Related to Release of Neurobiochemical Markers of Brain Damage [J]. Stroke,1999,30(6):1190-1195..
11. 陈烧洋,熊利泽,曾祥龙,等.麻醉和手术中脑氧供需平衡研究进展[J]. 解放军医学杂志,2002,27(2):187..
12. 孙海云,黄品婕,等.参附注射液对全麻气管插管应激反应的影响[J]. 海南医学,2005,16(12):66-67..

West China Medical Journal

参附注射液对行颅内动脉瘤夹闭术患者血清SOD,MDA,S-100β 蛋白的影响

Abstract Full text Figures/Tables Video References Cited by

Format

Content