Effects of Bisorpolol and Indapamide Combination Therapy on Blood Pressure in the Patients with Mild to Moderate Essential Hypertension_West China Medical Journal

Authors：

TANG Hongbin.

Department of Cardiology, the People’s Hospital of Tongnan County, Chongqing, China;

Corresponding author：

Keywords：

高血压; 吲哒帕胺; 比索洛尔; 联合治疗

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目的:探讨小剂量吲哒帕胺联合比索洛尔治疗原发性高血压患者的安全性和疗效。方法: 60例初诊的高血压Ⅰ级、Ⅱ级患者,随机分为治疗组及对照组。治疗组予以吲哒帕胺25mg/次,及比索洛尔25mg/次,每天早晨7时服药1次;对照组单用吲哒帕胺25mg/次,每天早晨7时口服1次,疗程8周。结果: 两组患者血压(收缩压及舒张压)均有下降,但以治疗组血压下降明显。治疗组显效13例,有效14例;对照组显效8例,有效15例;治疗组总有效率为90%,治疗组无效率为10%;对照组有效率767%,无效率233%,2组疗效差异有统计学意义(P lt;005)。两组不良反应相似,治疗前后生化指标变化差别无统计学意义。结论:比索洛尔联合吲哒帕胺治疗原发性高血压安全有效,对糖、脂代谢无明显影响。

Citation： TANG Hongbin.. Effects of Bisorpolol and Indapamide Combination Therapy on Blood Pressure in the Patients with Mild to Moderate Essential Hypertension. West China Medical Journal, 2009, 24(5): 1126-1128. doi: Copy

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1. 中国高血压防治指南 [J]. 中国卒中杂志, 2006, 8: 57582.
2. 杨秀兰, 熊鹰, 彭程, 等. 小剂量比索洛尔和吲哒帕胺治疗中年妇女高血压效果观察[J]. 武警医学, 2003, 14(7): 413.
3. REITER MJ. Cardiovascular drug class specificity: betablockers [J]. Prog Cardiovasc Dis, 2004, 47(1):1133.
4. CIBISⅡ investigators and committees. The Cardiac Insufficiency Bisoprolol Study Ⅱ (CIBISⅡ): a randomised trial [J]. Lancet, 1999, 353(9146):913.
5. 曾智桓, 黄旭明, 周万兴, 等. 吲哒帕胺对原发性高血压患者代谢的影响[J]. 临床心血管病杂志, 1999, 8: 377.
6. BENETOS A, CONSOLI S, SAFAVIAN A, et al. Efficacy, safety, and effects on quality of life of bisoprolol/hydrochlorothiazide versus amlodipine in elderly patients with systolic hypertension[J]. Am Heart J, 2000, 140(4):E11.

West China Medical Journal

Effects of Bisorpolol and Indapamide Combination Therapy on Blood Pressure in the Patients with Mild to Moderate Essential Hypertension

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