Eukaryotic Translation Initiation Factor 4e Expression in Endometrioid Adenocarcinoma and Its Significance_West China Medical Journal

Authors：

1Department of Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China;

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Keywords：

真核细胞翻译起始因子4E; 子宫内膜样腺癌; 免疫组织化学

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摘要:目的:探讨子宫内膜样腺癌组织中真核细胞翻译起始因子4E(eIF4E)的表达情况及意义。方法:应用免疫组织化学技术检测124例子宫内膜样腺癌及20例正常子宫内膜组织中eIF4E的表达情况,同时结合患者的临床病理资料进行分析。结果:子宫内膜样腺癌和正常子宫内膜组织中eIF4E的阳性表达率分别为726%和50%,差异有统计学意义(P=0000 lt;005)。eIF4E的表达与肿瘤组织分化程度明显相关(P=0039 lt;005),而与FIGO分期无明显相关(P=0296 gt;005)。结论:过度表达的eIF4E可能作为判断子宫内膜恶变及恶性程度的分子标志。

Citation： WANG Xiaoli,YANG Hua,HUANG Juan,et al. Eukaryotic Translation Initiation Factor 4e Expression in Endometrioid Adenocarcinoma and Its Significance. West China Medical Journal, 2009, 24(5): 1150-1152. doi: Copy

1.
2.	DE BENEDETTIA, GRAFF JR. eIF4E expression and its role in malignancies and metastases[J]. Oncogene,2004,23(18):31893199.
3.	KEREKATTE V, SMILEY K, HU B, et al.The protooncogene translation factor eIF4E: a survey of its expression in breast carcinomas[J]. Int J Cancer,1995,64(1):2731.
4.	LI BD, LIU L, DAWSON M, et al. Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma[J]. Cancer,1997,79(12):23852390.
5.	ZHOU S, WANG GP, LIU C, et al. Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer[J]. BMC Cancer,2006,6:231.
6.	SORRELLS DL JR, GHALI GE, DE BENEDETTI A, et al. Progressive amplification and overexpression of the eukaryotic initiation factor 4E gene in different zones of head and neck cancers[J]. J Oral Maxillofac Surg,1999,57(3):294299.
7.	DE BENEDETTIA, GRAFF JR. eIF4E expression and its role in malignancies and metastases[J]. Oncogene,2004,23(18):31893199.
8.	NATHAN CO, FRANKLIN S, ABREO FW, et al. Analysis of surgical margins with the molecular marker eIF4E: a prognostic factor in patients with head and neck cancer[J]. J Clin Oncol,1999,17(9):29092914.
9.	FRANKLIN S, PHO T, ABREO FW, et al. Detection of the protooncogene eIF4E in larynx and hypopharynx cancers[J]. Arch Otolaryngol Head Neck Surg,1999,125(2):177182.
10.	LEE JW, CHOI JJ, LEE KM, et al. eIF4E expression is associated with histopathologic grades in cervical neoplasia[J]. Hum Pathol,2005,36(11):11971203.
11.	熊碧芳,方向明,胡继军.91例胃癌患者真核细胞起始因子与血管内皮生长因的表达及其临床意义[J].临床内科杂志,2005,22(11):743745.

1.
2. DE BENEDETTIA, GRAFF JR. eIF4E expression and its role in malignancies and metastases[J]. Oncogene,2004,23(18):31893199.
3. KEREKATTE V, SMILEY K, HU B, et al.The protooncogene translation factor eIF4E: a survey of its expression in breast carcinomas[J]. Int J Cancer,1995,64(1):2731.
4. LI BD, LIU L, DAWSON M, et al. Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma[J]. Cancer,1997,79(12):23852390.
5. ZHOU S, WANG GP, LIU C, et al. Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer[J]. BMC Cancer,2006,6:231.
6. SORRELLS DL JR, GHALI GE, DE BENEDETTI A, et al. Progressive amplification and overexpression of the eukaryotic initiation factor 4E gene in different zones of head and neck cancers[J]. J Oral Maxillofac Surg,1999,57(3):294299.
7. DE BENEDETTIA, GRAFF JR. eIF4E expression and its role in malignancies and metastases[J]. Oncogene,2004,23(18):31893199.
8. NATHAN CO, FRANKLIN S, ABREO FW, et al. Analysis of surgical margins with the molecular marker eIF4E: a prognostic factor in patients with head and neck cancer[J]. J Clin Oncol,1999,17(9):29092914.
9. FRANKLIN S, PHO T, ABREO FW, et al. Detection of the protooncogene eIF4E in larynx and hypopharynx cancers[J]. Arch Otolaryngol Head Neck Surg,1999,125(2):177182.
10. LEE JW, CHOI JJ, LEE KM, et al. eIF4E expression is associated with histopathologic grades in cervical neoplasia[J]. Hum Pathol,2005,36(11):11971203.
11. 熊碧芳,方向明,胡继军.91例胃癌患者真核细胞起始因子与血管内皮生长因的表达及其临床意义[J].临床内科杂志,2005,22(11):743745.

West China Medical Journal

Eukaryotic Translation Initiation Factor 4e Expression in Endometrioid Adenocarcinoma and Its Significance

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