目的:探讨孟鲁司特钠(顺尔宁)对呼吸道合胞病毒(RSV)毛细支气管炎患儿血清中半胱氨酰白三烯(CysLTs)的影响。方法:将60例4～18个月的RSV毛细支气管炎患儿随机分为顺尔宁治疗组(30例)和常规治疗组(30例),常规治疗组仅给予综合治疗,而顺尔宁治疗组在综合治疗的基础上加用孟鲁司特口服,用法为4mg每晚1次口服。于治疗前和治疗后检测血清中CysLTs水平。结果:治疗前,RSV毛细支气管炎两组CysLTs水平均明显高于正常组(P lt;005),同时CysLTs水平较常规治疗组显著下降(P lt;005),常规治疗组患儿血清CysLTs水平仍高于正常组(P lt;005)。结论:顺尔宁可降低RSV毛细支气管炎患儿血清中CysLTs水平,在RSV毛细支气管炎的抗炎机制中起重要作用,推测RSV毛细支气管炎患儿口服孟鲁司特有可能达到早期干预,从另一条途径减少哮喘的发病。
Citation：
LI Lan,FAN Hong,HU Yiping,et al. The Comparison of CysteinylLeukotrenes in Children with Bronchiolitis Before and After Montelukast. West China Medical Journal, 2009, 24(5): 1152-1153. doi:
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OH J W, SHIN S A, LEE H B. Urine leukotriene E4 and eosinophil cationic protein in nasopharyngeal aspiration from young wheezy children [J]. Pediatr Allergy Immunol,2005,16(5):416421.
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BONVILLE C A, ROSENBERG H F, DOMACHOWSKE J B. Ribavirin and cysteinylleukotriene 1 receptor blockade as treatment for severe bronchiolitis[J]. Antiviral Res,2006,69(2):53.
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- 1. OH J W, SHIN S A, LEE H B. Urine leukotriene E4 and eosinophil cationic protein in nasopharyngeal aspiration from young wheezy children [J]. Pediatr Allergy Immunol,2005,16(5):416421.
- 2. WELLIVER R C. Therapy for bronchiolitis:Help wanted [J]. J Pediatr,1997,130(2):170.
- 3. PIEDIMONTE G, SIMOES E A. Respiratory syncytial virus and subsequent asthma[J]. Eur Respir J,2002,20(3):515517.
- 4. NGAMPHAIBOON J. Montelukast in general pedi atric practices [J]. J Med Assoc Thai,2005,88(4):348.
- 5. BONVILLE C A, ROSENBERG H F, DOMACHOWSKE J B. Ribavirin and cysteinylleukotriene 1 receptor blockade as treatment for severe bronchiolitis[J]. Antiviral Res,2006,69(2):53.
