Effects of Soybean Isoflavones on Antioxidative Action in Aged Rats_West China Medical Journal

Authors：

ZHANG Yanling , YANG Zhonghua , DONG Birong

Department of Geriatric, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

丙二醛; 超氧化物歧化酶; 谷胱甘肽过氧化酶; 大豆异黄酮

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目的:研究大豆异黄酮对D半乳糖致衰老大鼠抗氧化能力的影响。方法:用D半乳糖注射Wistar雄性大鼠5个月,建立衰老模型。对致衰老模型组、大豆异黄酮组肝脏、心脏和前列腺丙二醛(MDA)含量、超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSHPx)活性进行测定及比较。结果:低、中、高不同剂量大豆异黄酮灌喂组与模型组大鼠相比,各脏器MDA含量(μmol/L)(心脏:695±093,562±112,435±112比802±111;肝脏:815±085,647±120,515±112比935±135;前列腺:715±092,558±115,423±125比833±124)均有降低,差异有统计学意义(P lt;005),而SOD酶活性(nmol/L)(心脏:4732±308,5518±428,6120±368比3225±370;肝脏:18121±506,19015±706,19720±570比17213±512;前列腺:4156±301,4607±421,5015±335比3374±305)和GSHPx酶活性(nmol/L)(心脏:905±096,1111±245,1313±146比713±151;肝脏:902±105,1150±223,1362±192比698±160;前列腺:435±085,613±102,747±155比312±106)有升高,差异同样具有统计学意义(P lt;005);大豆异黄酮摄入量越高,MDA含量越低,而SOD、GSHPx酶活性越高。结论:摄入适量大豆异黄酮可有效增强大鼠机体抗氧化能力,从而延缓D半乳糖诱发的大鼠衰老。

Citation： ZHANG Yanling,YANG Zhonghua,DONG Birong. Effects of Soybean Isoflavones on Antioxidative Action in Aged Rats. West China Medical Journal, 2009, 24(5): 1183-1185. doi: Copy

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4.
5.	WISEMAN H, O’Reilly J D, Adlercreutz H, et al. Isoflavone phytoestrogens consumed in decrease F2isoprostane concentrations and increase resistance of lowdensity lipoprotein to oxidation in humans[J]. Am J Clin Nutr,2000,72:395400.
6.	惠伯棣.类胡萝卜素化学及生物化学[M].北京:中国轻工业出版社,2005:312327.
7.	裴凌鹏,金宗濂.葛根黄酮改善小鼠抗氧化功能的研究[J].营养学报,2004,26(6):505506.
8.	DE ZWART L L, MEERMAN J H N, COMMANDEUR J N M, et al. Biomarkers of free radical damage: applications in experimental animals and in humans[J]. Free Radic Biol Med,1999,26(12):202226.
9.	MILLER E, MALINOWSK K, GATECKA E, et al. Role of flavonoids as antioxidants in human organism[J]. Pol Merkur Lekarski,2008,24(144):556560.
10.	WEI H C, CAI Q Y, RAHN R O. Inhibition of UV light and Fenton reactioninduced oxidative DNA damage by the soybean isoflavone genistein[J]. Carcinogenesis,1996,17(1): 7377.
11.	WOOD C E, CLINE J M, ANTHONY M S, et al. Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys[J]. J Clin Endocrinol Metab,2004,89(5):23192325.
12.	Hong J L, Ho C Y, Kwong K, et al. Activation of pulmonary C fibres by adenosine in anaesthetized rats: role of adenosine A1 receptors[J]. J Physiol,1998,508(Pt 1):109118.

1.
2.
3.
4.
5. WISEMAN H, O’Reilly J D, Adlercreutz H, et al. Isoflavone phytoestrogens consumed in decrease F2isoprostane concentrations and increase resistance of lowdensity lipoprotein to oxidation in humans[J]. Am J Clin Nutr,2000,72:395400.
6. 惠伯棣.类胡萝卜素化学及生物化学[M].北京:中国轻工业出版社,2005:312327.
7. 裴凌鹏,金宗濂.葛根黄酮改善小鼠抗氧化功能的研究[J].营养学报,2004,26(6):505506.
8. DE ZWART L L, MEERMAN J H N, COMMANDEUR J N M, et al. Biomarkers of free radical damage: applications in experimental animals and in humans[J]. Free Radic Biol Med,1999,26(12):202226.
9. MILLER E, MALINOWSK K, GATECKA E, et al. Role of flavonoids as antioxidants in human organism[J]. Pol Merkur Lekarski,2008,24(144):556560.
10. WEI H C, CAI Q Y, RAHN R O. Inhibition of UV light and Fenton reactioninduced oxidative DNA damage by the soybean isoflavone genistein[J]. Carcinogenesis,1996,17(1): 7377.
11. WOOD C E, CLINE J M, ANTHONY M S, et al. Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys[J]. J Clin Endocrinol Metab,2004,89(5):23192325.
12. Hong J L, Ho C Y, Kwong K, et al. Activation of pulmonary C fibres by adenosine in anaesthetized rats: role of adenosine A1 receptors[J]. J Physiol,1998,508(Pt 1):109118.

West China Medical Journal

Effects of Soybean Isoflavones on Antioxidative Action in Aged Rats

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