姜黄素抗肿瘤机制研究进展_West China Medical Journal

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林琳 , 王平 , 尹如铁 , 王丹青

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Citation： 林琳,王平,尹如铁,王丹青. 姜黄素抗肿瘤机制研究进展. West China Medical Journal, 2009, 24(5): 1320-1322. doi: Copy

1.	王箴.化工辞典.第4版[M].北京:化学工业出版社,2001:459.
2.	KUTTAN R, BHANUMATHY P, NIRMALA K, et al. Potential anticancer activity of turmeric(Curcuma longa)[J]. Cancer Lett,1985,29(2):197.
3.	ODOT J,ALBERT P,CARLIER A, et al. In vitro and in vivo antitumoral effect of curcumin against melanoma cells[J]. Int J Cancer,2004,111(3):381-387.
4.	CHAUHAN D P. Chemotherapeutic potential of curcumin for colorectal cancer[J]. Curr Pharm Des,2002,8(19):1695-1706.
5.	CHEN Y S, HO C C, CHENY C K, et al. Curcumin inhibited the arylamines Nacetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells(A549)[J]. Toxicol In Vitro,2003,17(3):323-333.
6.	BUSH J A, CHEUNG K J JR, LI G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase8 pathway independent of p53[J]. Exp Cell Res,2001,271(2):305314.
7.	刘立民,孔祥波,常喜华,等.姜黄素对前列腺癌PC3M细胞生长抑制和凋亡的影响[J].吉林大学学报:医学版,2007,33(2):283-285.
8.	郑丽端,童强松,吴翠环,等.姜黄素诱导卵巢癌细胞株A2780细胞周期阻滞和凋亡[J].华中科技大学学报(医学版),2003,32(2):209-211.
9.	吴勇,陈元仲,许建华,等.姜黄素对人类Burkitt淋巴瘤抗癌作用的研究[J].中华肿瘤杂志,2002,24(4):348-351.
10.	田慧军,王笛乐.姜黄素诱导人结肠癌细胞株SW480凋亡及其bcl2表达相关性研究[J].肿瘤防治研究,2006,33(3):185-187.
11.	RAY S, CHATTOPADHYAY N, MITRA A, et al. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and Ecadherin[J]. Environ Pathol Toxicol Oncol,2003,22(1):49-58.
12.	ROBINSON T P, EHLERS T, HUBBARD Ⅳ R B, et al. Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin[J]. Bioorg Med Chem Lett,2003,13(1):115-117.
13.	LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
14.	LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
15.	GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
16.	GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
17.	BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
18.	BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
19.	CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):15151524.
20.	CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):1515-1524.
21.	DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473475.
22.	DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473-475.
23.	PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951960.
24.	PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951-960.
25.	HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253268.
26.	HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253-268.
27.	ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
28.	ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
29.	张慧珠,杨林,李小娜,等.姜黄素体外增敏抗肿瘤药物作用[J].华西药学杂志,2003,18(3):172-174.
30.	张慧珠,杨林,李小娜,等.姜黄素体外增敏抗肿瘤药物作用[J].华西药学杂志,2003,18(3):172-174.
31.	英焕春,张淑兰,吕靖.姜黄素逆转卵巢癌耐药细胞株COC1/DDP耐药性及机制的研究[J].现代肿瘤医学,2007,15(5):604-607.
32.	英焕春,张淑兰,吕靖.姜黄素逆转卵巢癌耐药细胞株COC1/DDP耐药性及机制的研究[J].现代肿瘤医学,2007,15(5):604-607.
33.	CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
34.	CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
35.	PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
36.	PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
37.	李昱辰,仲来福.姜黄素对顺铂所致大鼠肾毒性的防护作用及其可能机制[J].毒理学杂志,2005,19(3):270.
38.	李昱辰,仲来福.姜黄素对顺铂所致大鼠肾毒性的防护作用及其可能机制[J].毒理学杂志,2005,19(3):270.
39.	张英,王顺蓉,陈蓉,等.姜黄素抗顺铂肾毒性作用及其机制研究[J].时珍国医国药,2007,18(7):1673-1675.
40.	张英,王顺蓉,陈蓉,等.姜黄素抗顺铂肾毒性作用及其机制研究[J].时珍国医国药,2007,18(7):1673-1675.
41.	孙雅煊,王振华,李刚,等.姜黄素降低环磷酰胺致微核形成率[J].兰州大学学报(医学版),2006,32(3):27-30.
42.	孙雅煊,王振华,李刚,等.姜黄素降低环磷酰胺致微核形成率[J].兰州大学学报(医学版),2006,32(3):27-30.
43.	WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
44.	WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
45.	BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
46.	BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
47.	SCOTT D W, LOO G. Curcumin induced GADD153 gene up regulation in human colon cancer cells[J]. Carcinogenesis,2004,25(11):2155-2164.
48.	SCOTT D W, LOO G. Curcumin induced GADD153 gene up regulation in human colon cancer cells[J]. Carcinogenesis,2004,25(11):2155-2164.

1. 王箴.化工辞典.第4版[M].北京:化学工业出版社,2001:459.
2. KUTTAN R, BHANUMATHY P, NIRMALA K, et al. Potential anticancer activity of turmeric(Curcuma longa)[J]. Cancer Lett,1985,29(2):197.
3. ODOT J,ALBERT P,CARLIER A, et al. In vitro and in vivo antitumoral effect of curcumin against melanoma cells[J]. Int J Cancer,2004,111(3):381-387.
4. CHAUHAN D P. Chemotherapeutic potential of curcumin for colorectal cancer[J]. Curr Pharm Des,2002,8(19):1695-1706.
5. CHEN Y S, HO C C, CHENY C K, et al. Curcumin inhibited the arylamines Nacetyltransferase activity, gene expression and DNA adduct formation in human lung cancer cells(A549)[J]. Toxicol In Vitro,2003,17(3):323-333.
6. BUSH J A, CHEUNG K J JR, LI G. Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase8 pathway independent of p53[J]. Exp Cell Res,2001,271(2):305314.
7. 刘立民,孔祥波,常喜华,等.姜黄素对前列腺癌PC3M细胞生长抑制和凋亡的影响[J].吉林大学学报:医学版,2007,33(2):283-285.
8. 郑丽端,童强松,吴翠环,等.姜黄素诱导卵巢癌细胞株A2780细胞周期阻滞和凋亡[J].华中科技大学学报(医学版),2003,32(2):209-211.
9. 吴勇,陈元仲,许建华,等.姜黄素对人类Burkitt淋巴瘤抗癌作用的研究[J].中华肿瘤杂志,2002,24(4):348-351.
10. 田慧军,王笛乐.姜黄素诱导人结肠癌细胞株SW480凋亡及其bcl2表达相关性研究[J].肿瘤防治研究,2006,33(3):185-187.
11. RAY S, CHATTOPADHYAY N, MITRA A, et al. Curcumin exhibits antimetastatic properties by modulating integrin receptors, collagenase activity, and expression of Nm23 and Ecadherin[J]. Environ Pathol Toxicol Oncol,2003,22(1):49-58.
12. ROBINSON T P, EHLERS T, HUBBARD Ⅳ R B, et al. Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin[J]. Bioorg Med Chem Lett,2003,13(1):115-117.
13. LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
14. LIN Y G, KUNNUMAKKARA A B, NAIR A, et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factorκB pathway[J]. Clin Cancer Res,2007,13(11):3423-3430.
15. GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
16. GURURAJ A E, BELAKAVADR M, VENKATESH D A, et al. Molecular mechanisms of antiangiogenic effect of curcumin[J]. Biochem Biophys Res Commun,2002,297(4):934-942.
17. BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
18. BANERJI A, CHAKRABARTI J, MITRA A, et al. Effect of curcumin on gelatinase A(MMP2) activity in B16F10 melanoma cells[J]. Cancer Lett,2004,211(2):235-242.
19. CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):15151524.
20. CHUN K S, KEUM Y S, HAN S S, et al. Curcumin inhibits phorbol esterinduced expression of cyclooxygenase2 in mouse skin through suppression of extracellular signalregulated kinase activity and NFκB activation[J]. Carcinogenesis,2003,24(9):1515-1524.
21. DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473475.
22. DICKINSON D A, ILES K E, ZHANG H, et al. Curcumin alters EpRE and AP1 binding complexes and elevates glutamatecysteine ligase gene expression[J]. FASEB J,2003,17(3):473-475.
23. PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951960.
24. PRUSTY B K, Das B C. Constitutive activation of transcription factor AP1 in cervical cancer and suppression of human papillomavirus(HPV) transcription and AP1 activity in HeLa cells by curcumin[J]. Int J Cancer,2005,113(6):951-960.
25. HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253268.
26. HOLY J. Curcumin inhibits cell motility and alters microfilament organization and function in prostate cancer cells[J]. Cell Moti Cytoskeleton,2004,58(4):253-268.
27. ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
28. ANUCHAPREEDA S, LEECHANACHAI P, SMITH M M, et al. Modulation of Pglycoprotein expression and function by curcumin in multidrugresistant human KB cells[J]. Biochem Pharmacol,2002,64(4):573-582.
29. 张慧珠,杨林,李小娜,等.姜黄素体外增敏抗肿瘤药物作用[J].华西药学杂志,2003,18(3):172-174.
30. 张慧珠,杨林,李小娜,等.姜黄素体外增敏抗肿瘤药物作用[J].华西药学杂志,2003,18(3):172-174.
31. 英焕春,张淑兰,吕靖.姜黄素逆转卵巢癌耐药细胞株COC1/DDP耐药性及机制的研究[J].现代肿瘤医学,2007,15(5):604-607.
32. 英焕春,张淑兰,吕靖.姜黄素逆转卵巢癌耐药细胞株COC1/DDP耐药性及机制的研究[J].现代肿瘤医学,2007,15(5):604-607.
33. CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
34. CHAN M M, FONG D, SOPRANO K J, et al. Inhibition of growth and sensitization to cisplatinmediated killing of ovarian cancer cells polyphenolic chemopreventive agents[J]. J Cell Physiol,2003,194(1):63-70.
35. PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
36. PATEL B, SENGUPTA R, QAZI S, et al. Curcumin enhances the effects of 5fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF1R[J]. Int J Cancer,2008,122(2):267-273.
37. 李昱辰,仲来福.姜黄素对顺铂所致大鼠肾毒性的防护作用及其可能机制[J].毒理学杂志,2005,19(3):270.
38. 李昱辰,仲来福.姜黄素对顺铂所致大鼠肾毒性的防护作用及其可能机制[J].毒理学杂志,2005,19(3):270.
39. 张英,王顺蓉,陈蓉,等.姜黄素抗顺铂肾毒性作用及其机制研究[J].时珍国医国药,2007,18(7):1673-1675.
40. 张英,王顺蓉,陈蓉,等.姜黄素抗顺铂肾毒性作用及其机制研究[J].时珍国医国药,2007,18(7):1673-1675.
41. 孙雅煊,王振华,李刚,等.姜黄素降低环磷酰胺致微核形成率[J].兰州大学学报(医学版),2006,32(3):27-30.
42. 孙雅煊,王振华,李刚,等.姜黄素降低环磷酰胺致微核形成率[J].兰州大学学报(医学版),2006,32(3):27-30.
43. WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
44. WEIR N M, SELVENDIRAN K, KUTALA V K, et al. Curcumin induces G2/Marrest and apoptosis in cisplatinpesistant human ovarian cancer cells by modulating Akt and p38 MAPK[J]. Cancer Biol Ther,2007,6(2):178-184.
45. BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
46. BISWAS S K, MCCLURE D, JIMENEZ L A, et al. Curcumin induces glutathione biosynthesis and inhibits NFκB activation and interleukin8 release in alveolar epithelial cells: mechanism of free radical scavenging activity[J]. Antioxid Redox Signal,2005,7(12):32-41.
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West China Medical Journal

姜黄素抗肿瘤机制研究进展

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