hreeDimensional Conformal Hypofractionated Radiotherapy for NonSmall Cell Lung Cancer in Elderly Patients_West China Medical Journal

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Department of Radiation Oncology, Chengdu Army General Hospital, Chengdu 610083, China;

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Keywords：

老年人; 非小细胞肺癌; 大分割放疗; 三维适形放疗

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目的:评价70岁以上老年非小细胞肺癌患者大分割放疗的长期疗效和并发症。方法:对1997年8月至2003年2月收治的38例70岁以上非小细胞肺癌实施大分割三维适形放疗(3D-CRT),年龄70～85岁,中位年龄74岁。全组卡氏评分均≥70。其中Ⅰ期8例, Ⅱ期20例, Ⅲ期8例,Ⅳ期2例。结果:全组有效率(CR+PR)92.1%;1,2,3,5年生存率分别为94.7%、65.7%、38.9% 和 28.0%。1,2 级急性放射性食管炎发生率 47.4%(18/38);未出现急性症状性放射性肺炎,未发现严重心脏、食管、脊髓放射性反应。晚期局部肺放射性纤维化表现(CT和/或胸片)为34.2%(13/38).结论:不能手术的老年非小细胞肺癌患者大分割适形放射治疗,安全有效,副作用可以耐受。

Citation： LUO Jianhua,XIAN Jing,PAN Xingguo,et al.. hreeDimensional Conformal Hypofractionated Radiotherapy for NonSmall Cell Lung Cancer in Elderly Patients. West China Medical Journal, 2009, 24(6): 1412-1415. doi: Copy

1.	罗扬,郝学志,张湘茹.老年晚期非小细胞肺癌的化疗可行性[J].肿瘤防治研究,2002,29(3):238-240.
2.	杨志雄,梁荣,黄杰,等.放化联合治疗老年非小细胞肺癌的可行性[J].肿瘤防治研究,2003,30(3):228-230.
3.	TOMBOLINI V,BONANNI A,DONATO V, et al. Radiotherapy alone in eldely patients with medically inoperable stage ⅢA and ⅢB nonsmall cell lung cancer [J].Antican Res,2000,20 (60):4829-4833.
4.	MOVSAS B,SCOTT C,SAUSE W, et al. The benefit of treatment intensification is age and histologypendent in patients with locally advanced nonmall cell lung cancer (NSCLC):a quality adjusted survival analysis of radiation therapy oncology group (RTOG) chemoradiation studies [J]. Int J Radiat Oncol Biol Phys,1999,45 (5):1143-1149.
5.	SCHILD SE, STELLA PJ, GEYER SM, et al. The outcome of combinedmodality therapy for stage Ⅲ nonsmall cell lung cancer in the elderly[J]. J Clin Oncol,2003,21 (17):3201-3206.
6.	MARTEL MK,TEN HAKEN RK, HAZUKA MB, et al. Estimation of tumor control probability model parameters from 3D dose distributions of nonsmall cell lung cancer patients [J].J Lung cancer,1999,24:31-37.
7.	陈龙华.59例肿瘤立体定向适形放疗的初步经验[J]. J广东医学,1999,20(10):755-756.
8.	王淑莲,刘跃平,孙倩. 放射肿瘤学——治疗策略与实施. 天津科技翻译出版公司,2001,14.
9.	CHEUNG PC, M ACKILLOP WJ, DIXON P, et al.Involvedfield radiotherapy alon for earlystage nonsmallcell lung caner. [J].Int J Radiat Oncol Biol Phys 2000,48:703-710.
10.	MAGUIRE PD,MARKS LB, SIBLEY GS, et al.736Gy and beyond hyperfractionated accelerated radiotherapy for nonsmallcall lung cancer [J]. [11]KONG FM, TEN HAKEN RK, SCHIPPERMJ, et al. Highdose radiation improed local tumor control and survival in patients with inoperable /unresectable nonsmall cell lung cancer: longterm result of a radiation dose escalation study [J]. Int J Radiat Oncol Biol Phys,2005,63(2):3242-3331.
11.	刘子莹,卢冰,欧阳伟炜,等.早期非小细胞肺癌大分割放射治疗临床研究[J].J肿瘤预防与治疗,2008,(21)2:152-154.
12.	CHEN M, JIANG GL, FU XL, et al.The impact of overall treatment time on outcomes in radiation therapy for nonsmallcell lung cancer.Lung Cancer 2000,28:11-19.
13.	骆建华,曾兴炳,潘兴国,等.非小细胞肺癌常规外照射结合三维适形照射的临床研究[J].J四川医学2004,9(25):980-981.
14.	吴开良,蒋国梁,廖源,等.非小细胞肺癌三维放射适形放射治疗I和Ⅱ期剂量递增实验结果分析 [J].中华放射肿瘤学杂志,2003,1(1)10-13.
15.	HIR OSHI O, YASUSHI N, HIR OKI S, et al. Stereotactic Hypofractionated highdose irradiation for patients with stage I non mall cell lung carcinoma: clinical outcomes in 241 cases of a Japanese multiinstitutionalstudy[J]. (Abstr) Int J Radiat Oncol Biol Phys, 2003,57:S124.

1. 罗扬,郝学志,张湘茹.老年晚期非小细胞肺癌的化疗可行性[J].肿瘤防治研究,2002,29(3):238-240.
2. 杨志雄,梁荣,黄杰,等.放化联合治疗老年非小细胞肺癌的可行性[J].肿瘤防治研究,2003,30(3):228-230.
3. TOMBOLINI V,BONANNI A,DONATO V, et al. Radiotherapy alone in eldely patients with medically inoperable stage ⅢA and ⅢB nonsmall cell lung cancer [J].Antican Res,2000,20 (60):4829-4833.
4. MOVSAS B,SCOTT C,SAUSE W, et al. The benefit of treatment intensification is age and histologypendent in patients with locally advanced nonmall cell lung cancer (NSCLC):a quality adjusted survival analysis of radiation therapy oncology group (RTOG) chemoradiation studies [J]. Int J Radiat Oncol Biol Phys,1999,45 (5):1143-1149.
5. SCHILD SE, STELLA PJ, GEYER SM, et al. The outcome of combinedmodality therapy for stage Ⅲ nonsmall cell lung cancer in the elderly[J]. J Clin Oncol,2003,21 (17):3201-3206.
6. MARTEL MK,TEN HAKEN RK, HAZUKA MB, et al. Estimation of tumor control probability model parameters from 3D dose distributions of nonsmall cell lung cancer patients [J].J Lung cancer,1999,24:31-37.
7. 陈龙华.59例肿瘤立体定向适形放疗的初步经验[J]. J广东医学,1999,20(10):755-756.
8. 王淑莲,刘跃平,孙倩. 放射肿瘤学——治疗策略与实施. 天津科技翻译出版公司,2001,14.
9. CHEUNG PC, M ACKILLOP WJ, DIXON P, et al.Involvedfield radiotherapy alon for earlystage nonsmallcell lung caner. [J].Int J Radiat Oncol Biol Phys 2000,48:703-710.
10. MAGUIRE PD,MARKS LB, SIBLEY GS, et al.736Gy and beyond hyperfractionated accelerated radiotherapy for nonsmallcall lung cancer [J]. [11]KONG FM, TEN HAKEN RK, SCHIPPERMJ, et al. Highdose radiation improed local tumor control and survival in patients with inoperable /unresectable nonsmall cell lung cancer: longterm result of a radiation dose escalation study [J]. Int J Radiat Oncol Biol Phys,2005,63(2):3242-3331.
11. 刘子莹,卢冰,欧阳伟炜,等.早期非小细胞肺癌大分割放射治疗临床研究[J].J肿瘤预防与治疗,2008,(21)2:152-154.
12. CHEN M, JIANG GL, FU XL, et al.The impact of overall treatment time on outcomes in radiation therapy for nonsmallcell lung cancer.Lung Cancer 2000,28:11-19.
13. 骆建华,曾兴炳,潘兴国,等.非小细胞肺癌常规外照射结合三维适形照射的临床研究[J].J四川医学2004,9(25):980-981.
14. 吴开良,蒋国梁,廖源,等.非小细胞肺癌三维放射适形放射治疗I和Ⅱ期剂量递增实验结果分析 [J].中华放射肿瘤学杂志,2003,1(1)10-13.
15. HIR OSHI O, YASUSHI N, HIR OKI S, et al. Stereotactic Hypofractionated highdose irradiation for patients with stage I non mall cell lung carcinoma: clinical outcomes in 241 cases of a Japanese multiinstitutionalstudy[J]. (Abstr) Int J Radiat Oncol Biol Phys, 2003,57:S124.

West China Medical Journal

hreeDimensional Conformal Hypofractionated Radiotherapy for NonSmall Cell Lung Cancer in Elderly Patients

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