Clinical Analysis of 157 Case of Drug Hepatitis Results from Tuberculosis Chemotherapy_West China Medical Journal

Authors：

LAN Mingcui.

Infectious Diseases Department, the First People’s Hospital of Liangshan Yi Autonomous Prefecture, Xichang Sichuan 615000, China;

Corresponding author：

Keywords：

结核病; 化疗; 药物性肝炎

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目的:探讨临床一线抗结核药物引起肝损害状况及预后,以提高对结核化疗致药物性肝炎的认识。方法:采用回顾性对比分析短程间歇化疗方案(2H3R3Z3E3/4H3R3)与短程每日化疗方案(2HRES/7HRE)之间抗结核治疗后对肝功能损害的发生率。结果:1144例中,发生药物性肝损害157例,其中间歇化疗方案发生药物性肝损害118例,占75.2%,每日化疗方案发生药物性肝损害39例,占24.8%。同时还发现体质状况差、病情重、老年人及有慢性酗酒者结核药物性肝损害发生率高。结论:药物性肝炎是影响结核病化疗的重要因素。短程间歇化疗方案治疗应因人而异,不宜广泛用于老年人、体质状况差、病情重、有慢性酗酒者的结核病患者。

Citation： LAN Mingcui.. Clinical Analysis of 157 Case of Drug Hepatitis Results from Tuberculosis Chemotherapy. West China Medical Journal, 2009, 24(6): 1442-1445. doi: Copy

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West China Medical Journal

Clinical Analysis of 157 Case of Drug Hepatitis Results from Tuberculosis Chemotherapy

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