The Preliminary Study of Relation between Helicobacter Pylori Infection and Upper Gastrointestinal Tract Diseases_West China Medical Journal

Authors：

YU Weihua , WANG Yiping.

Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Hp感染; 上消化道疾病

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目的:探讨幽门螺杆菌(Hp)感染与各种常见上消化道疾病的关系。方法:回顾性地分析了2008年于我院采用快速尿素酶试验(RUT)检测Hp的6636例门诊及住院患者Hp感染情况,及与性别、年龄、病种的关系。结果:6636例患者中,Hp阳性3248例,检出率为48.9%;其中男性4391例,检出率为49.97%,女性2 245例,检出率为46.9%,男性略高于女性,差异有统计学意义(P lt;0.05);20～29岁和30～39岁这两个年龄段Hp检出率最高,分别为58.4%和54.6%, lt;20岁Hp检出率最低(38.8%),各组间差异有统计学意义(P lt;0.01);各种常见的上消化道疾病,复合性溃疡和上消化道恶性肿瘤Hp检出率最高,分别为86.2%和84.1%,其次是幽门管溃疡和十二指肠溃疡,检出率分别为54.2%和51.9%,慢性胃炎、残胃炎、胃溃疡和食管静脉曲张Hp检出率分别为46.9%、40.0%、36.6%和34.2%,各组间的差异有显著的统计学意义(P lt;0.005)。结论:本组资料Hp总检出率为48.9%,男性略高于女性,慢性胃炎、消化性溃疡和上消化道恶性肿瘤与Hp感染密切相关,尤以复合性溃疡和上消化道恶性肿瘤更为显著。

Citation： YU Weihua,WANG Yiping.. The Preliminary Study of Relation between Helicobacter Pylori Infection and Upper Gastrointestinal Tract Diseases. West China Medical Journal, 2009, 24(6): 1447-1449. doi: Copy

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9.	张琴,吕鸣,杨龙,吕有灵.幽门螺旋杆菌菌感染与老年人上消化道疾病的关系[J].中华消化杂志,2005,25(11):697.
10.	DE MARTEL C, PARSONNET J.Helicobacter pylori Infection and Gender: A MetaAnalysis of PopulationBased Prevalence Surveys[J]. Dig Dis Sci,2006,51(12): 2292–2301.
11.	WU HC,TUO BG,WU WM, et al.Prevalence of Peptic Ulcer in Dyspeptic Patients and the Influence of Age,Sex,and Helicobacter pylori Infection[J].Dig Dis Sci,2008, 53(10):2650–2656.
12.	ZHANG Q,LI Y, LI X, et al. PARP1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population[J].Mol Biol Rep,2008,21.
13.	SUGIYAMA T.Development of gastric cancer associated with Helicobacter pyloriInfection[J].Cancer Chemother Pharmacol,2004,54(Suppl 1):S12-20.
14.	OHATA H,KITAUCHI S,YOSHIMURA N, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer [J].Int J Cancer,2004,109(1):138-143.
15.	ALEMPIJEVI T,KRSTI M,ANTONI V, et al. Frequency of Helicobacter pylori infection in patients with liver cirrhosis[J].Srp Arh Celok Lek,2007,135 (9-10):536-540.
16.	王英凯,金晶兰,朴云峰等.幽门螺杆菌感染与肝硬化[J].临床肝胆病杂志,2006,22(5):359-360.
17.	KIM DJ, KIM HY, KIM SJ. Helicobacter pylori infection and peptic ulcer disease in patients with liver cirrhosis[J]. Korean J Intern Med, 2008,23(1):16-21.
18.	周丽雅,沈祖尧,林三仁.根除幽门螺杆菌对胃黏膜炎症变化的人群随访研究[J].中华内科杂志,2003,42(3):162-164.

1. 胡品津,胡伏莲.中华医学会第四次幽门螺杆菌全国学术会议纪要[J].中华消化杂志,2005,25(11):698-699.
2. 任书林,孙琦,赵宏宇.幽门螺杆菌感染与慢性胃炎、消化性溃疡及胃癌的发病关系[J].内蒙古民族大学学报(自然科学版),2002,17(6):537-541.
3. SHI R, XU S, ZHANG H, et al. Prevalence and risk factors for Helicobacter pylori infection in Chinese populations[J]. Helicobacter,2008,13(2):157-165.
4. BROWN LM.Helicobacter pylori: Epidemiology and Routes of Transmission[J]. Epidemiol Rev,2000,22(2):283-297.
5. 饶正伟,冯刚,冯轶,黄芝敏.5000例消化系统疾病患者胃镜检查结果和HP感染情况的调查分析[J].贵州医药,2008,32(4):361-363.
6. 李书印.南阳市常见上消化道疾病患者HP感染流行病学初步调查研究[J].中国自然医学杂志,2008,10(5):371-373.
7. CHENG H,HU F,ZHANG L, et al.Prevalence of Helicobacter pylori infection and identification of risk factors in rural and urban Beijing, China[J]. Helicobacter, 2009,14(2):128-133.
8. 娄文辉,张娜,杨瑞权.600例老年人幽门螺旋杆菌感染与上消化道疾病的关系[J].吉林医学,2007,28(9):1087-1088.
9. 张琴,吕鸣,杨龙,吕有灵.幽门螺旋杆菌菌感染与老年人上消化道疾病的关系[J].中华消化杂志,2005,25(11):697.
10. DE MARTEL C, PARSONNET J.Helicobacter pylori Infection and Gender: A MetaAnalysis of PopulationBased Prevalence Surveys[J]. Dig Dis Sci,2006,51(12): 2292–2301.
11. WU HC,TUO BG,WU WM, et al.Prevalence of Peptic Ulcer in Dyspeptic Patients and the Influence of Age,Sex,and Helicobacter pylori Infection[J].Dig Dis Sci,2008, 53(10):2650–2656.
12. ZHANG Q,LI Y, LI X, et al. PARP1 Val762Ala polymorphism, CagA+ H. pylori infection and risk for gastric cancer in Han Chinese population[J].Mol Biol Rep,2008,21.
13. SUGIYAMA T.Development of gastric cancer associated with Helicobacter pyloriInfection[J].Cancer Chemother Pharmacol,2004,54(Suppl 1):S12-20.
14. OHATA H,KITAUCHI S,YOSHIMURA N, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer [J].Int J Cancer,2004,109(1):138-143.
15. ALEMPIJEVI T,KRSTI M,ANTONI V, et al. Frequency of Helicobacter pylori infection in patients with liver cirrhosis[J].Srp Arh Celok Lek,2007,135 (9-10):536-540.
16. 王英凯,金晶兰,朴云峰等.幽门螺杆菌感染与肝硬化[J].临床肝胆病杂志,2006,22(5):359-360.
17. KIM DJ, KIM HY, KIM SJ. Helicobacter pylori infection and peptic ulcer disease in patients with liver cirrhosis[J]. Korean J Intern Med, 2008,23(1):16-21.
18. 周丽雅,沈祖尧,林三仁.根除幽门螺杆菌对胃黏膜炎症变化的人群随访研究[J].中华内科杂志,2003,42(3):162-164.

West China Medical Journal

The Preliminary Study of Relation between Helicobacter Pylori Infection and Upper Gastrointestinal Tract Diseases

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