Expression of Acid sensing Ion Channels in Petrosal Ganglion_West China Medical Journal

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the Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China;

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Keywords：

岩神经节; 酸敏感离子通道; 异聚体

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目的:探讨酸敏感离子通道(acid-sensing ion channels，ASICs)的四种亚型即ASIC1a、ASIC1b、ASIC2a和ASIC3是否表达于大鼠岩神经节(petrosal ganglion)神经元。方法:采用常规免疫组化法(PV法)，观察正常大鼠岩神经节神经元是否表达ASIC1a、ASIC1b、ASIC2a和ASIC3。结果:在正常大鼠岩神经节神经元，可见ASIC1a、ASIC1b、ASIC2a和ASIC3表达;ASIC1a与ASIC2a，ASIC3与ASIC1b，ASIC3与ASIC1a，ASIC3与ASIC2a在岩神经节神经元上共表达。结论:正常生理情况下，大鼠岩神经节神经元均表达ASIC1a、ASIC1b、ASIC2a和ASIC3;ASICs亚型之间的共表达提示,在岩神经节可能存在ASICs异聚体的方式。

Citation： CHEN Qi,PAN Ji gang,CAO Xingling,et al. Expression of Acid sensing Ion Channels in Petrosal Ganglion. West China Medical Journal, 2009, 24(6): 1470-1472. doi: Copy

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2.	伍龙军,徐天乐.酸敏感离子通道研究进展[J].生物化学与生物物理进展,2002,29(2):197-201..
3.	伍龙军,徐天乐.酸敏感离子通道的功能及其相关调控[J].生物化学与生物物理进展,2003,3(3):339-343..
4.	DUAN B, WU L J, YU Y Q, et al. Upregulation of acidsensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity[J]. J Neurosci,2007,27:11139-11148..
5.	CHEN C C, ZIMMER A, SUN W H, et al. A role for ASIC3 in the modulation of highintensity pain stimuli[J]. Proc Natl Acad Sci,2002,99:8992-8997..
6.	曹性玲,陈祁,周华,等.ASIC1b、ASIC2a和ASIC3在大鼠脑干斜方体核和旁巨细胞外侧核的表达和间歇性缺氧对其表达的影响[J].四川大学学报(已接受,待发表)..
7.	TAN Z Y, LU Y J, WHITEIS C A, et al. Acidsensing ion channels contribute to transduction of extracellular acidosis in rat carotid body glomus cells[J]. Circ Res,2007,101:1009-1019..
8.	李丹, 陈海锋, 唐玉红,等. 酸刺激对大鼠颈动脉体l型细胞酸敏感离子通道亚型表达的影响[J].生理学报,2009,61(1): 43-48..
9.	MALYSZ J, SCOTT V E, FALTYNEK C, et al. Characterization of human ASIC2a homomeric channels stably expressd in murine Ltkcells[J]. Life Sci,2008,82:30-40.
10.	UGAWA S, MINAMI Y, GUO W, et al. Receptor that leaves a sour taste in the mouth[J]. Nature,1998,395(6702): 555-556..
11.	CHU XP, MIESCH J, JOHNSON M, et al. Protongated channels in PC12 cells[J]. J Neurophysiol,2002,87:2555-2561..
12.	DE WEILLE J, BASSILANA F, LAZDUNSKI M, et al. Identification, functional expression and chromosomal localisation of a sustaion of a sustained human protongated channels[J]. FEBS Lett,1998,433:257-260..
13.	SLUKA K A, PRICE M P, BREESE N M, et al. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1[J]. Pain,2003,106:229-239..
14.	UGAWA S, ISHIDA Y, UEDA T, et al. Hypotonic stimuli enhance protongated currents of acidsensing ion channel1b[J]. Biochem Biophysiol Res Commun,2008,367:530-534..

1. REEH P, KRESS M. Molecular physiology of proton transduction in nociceptors[J]. Curr Opin Pharmcol,2001,1(1):45-51..
2. 伍龙军,徐天乐.酸敏感离子通道研究进展[J].生物化学与生物物理进展,2002,29(2):197-201..
3. 伍龙军,徐天乐.酸敏感离子通道的功能及其相关调控[J].生物化学与生物物理进展,2003,3(3):339-343..
4. DUAN B, WU L J, YU Y Q, et al. Upregulation of acidsensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity[J]. J Neurosci,2007,27:11139-11148..
5. CHEN C C, ZIMMER A, SUN W H, et al. A role for ASIC3 in the modulation of highintensity pain stimuli[J]. Proc Natl Acad Sci,2002,99:8992-8997..
6. 曹性玲,陈祁,周华,等.ASIC1b、ASIC2a和ASIC3在大鼠脑干斜方体核和旁巨细胞外侧核的表达和间歇性缺氧对其表达的影响[J].四川大学学报(已接受,待发表)..
7. TAN Z Y, LU Y J, WHITEIS C A, et al. Acidsensing ion channels contribute to transduction of extracellular acidosis in rat carotid body glomus cells[J]. Circ Res,2007,101:1009-1019..
8. 李丹, 陈海锋, 唐玉红,等. 酸刺激对大鼠颈动脉体l型细胞酸敏感离子通道亚型表达的影响[J].生理学报,2009,61(1): 43-48..
9. MALYSZ J, SCOTT V E, FALTYNEK C, et al. Characterization of human ASIC2a homomeric channels stably expressd in murine Ltkcells[J]. Life Sci,2008,82:30-40.
10. UGAWA S, MINAMI Y, GUO W, et al. Receptor that leaves a sour taste in the mouth[J]. Nature,1998,395(6702): 555-556..
11. CHU XP, MIESCH J, JOHNSON M, et al. Protongated channels in PC12 cells[J]. J Neurophysiol,2002,87:2555-2561..
12. DE WEILLE J, BASSILANA F, LAZDUNSKI M, et al. Identification, functional expression and chromosomal localisation of a sustaion of a sustained human protongated channels[J]. FEBS Lett,1998,433:257-260..
13. SLUKA K A, PRICE M P, BREESE N M, et al. Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1[J]. Pain,2003,106:229-239..
14. UGAWA S, ISHIDA Y, UEDA T, et al. Hypotonic stimuli enhance protongated currents of acidsensing ion channel1b[J]. Biochem Biophysiol Res Commun,2008,367:530-534..

West China Medical Journal

Expression of Acid sensing Ion Channels in Petrosal Ganglion

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