Clinical Effects of Neoadjuvant Chemotherapy on 36 Cases with Cervical Carcinoma_West China Medical Journal

Authors：

WANG Tongjie ¹ ,  XIONG Dongmei ²

1 Department of Obstetrics and Gynecology,the People’s Hospital of Jiangyou,Jiangyou Sichuan 621700, China;2Department of Obstetrics and Gynecology,the First People’s Hospital of Chengdu,Chengdu Sichuan 610016, China;

Corresponding author：

XIONG Dongmei, Email: xiongdm0116@yahoo.com.cn

Keywords：

宫颈癌; 新辅助化疗; 手术治疗

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

目的:探讨平阳霉素/博来霉素联合顺铂(BP方案)、5氟尿嘧啶+异环磷酰胺联合顺铂(FIP方案)在宫颈癌新辅助化疗(Neoadjuvant Chemotherapy, NACT)的疗效及临床意义。方法:2004～2008年我院收治的Ib2-IIb期巨块型宫颈癌共62例,其中36例行BP或FIP方案化疗1～2个疗程后行根治性手术,为研究组;另26例直接行根治性手术,为对照组;术前评价NACT的疗效,并比较两组术中出血量、术后病理特征及并发症。结果:研究组36例患者术前进行NACT有效率为86％;术后病理检查示淋巴结阳性率,阴道切缘阳性率及宫旁累及率均较对照组低,差异有显著性。结论:利用BP,FIP方案对宫颈癌患者进行新辅助化疗有效、安全、经济,可缩小癌肿体积,增加手术切除率。

Citation： WANG Tongjie,XIONG Dongmei. Clinical Effects of Neoadjuvant Chemotherapy on 36 Cases with Cervical Carcinoma. West China Medical Journal, 2009, 24(7): 1703-1704. doi: Copy

1.	王泽华.重视和规范宫颈癌的新辅助化疗[J]. 华中医学杂志,2007,31(6):423.
2.	REIN DT,KUR BACHER CM,BREIDENBACH M,et al.Weekly carbopiatin and docetaxel for locaiiy primary and recurrent cervical cancer;a phase Istudy[J]. Gynecol oncol,2002,87(1):98-103.
3.	乐杰主编.妇产科学[M].第7版.北京:人民卫生出版社,2007:265-266.
4.	EDLTORZA GILLIAN M,THOMAS.Neoadjuvant chemotherapy a useful strategy for the treatment off stage Ib cervix cancer[J].Gynecol Oncology,1993,49(2):153-155.
5.	曹泽毅.子宫颈癌治疗的变迁和思考[S].第八届全国妇科肿瘤会议专题讲座.上海:2004:26.
6.	TERMUNGRUANGLERT W, TRESUKOSOL D, VASURATNA A, et al. Neoadjuvant gemcitabine and cisplatin followed by radical surgery in(bulky) squamous cell carcinoma of cervix stage IB2[J]. Gynecol Oncol,2005,97:576 581.

1. 王泽华.重视和规范宫颈癌的新辅助化疗[J]. 华中医学杂志,2007,31(6):423.
2. REIN DT,KUR BACHER CM,BREIDENBACH M,et al.Weekly carbopiatin and docetaxel for locaiiy primary and recurrent cervical cancer;a phase Istudy[J]. Gynecol oncol,2002,87(1):98-103.
3. 乐杰主编.妇产科学[M].第7版.北京:人民卫生出版社,2007:265-266.
4. EDLTORZA GILLIAN M,THOMAS.Neoadjuvant chemotherapy a useful strategy for the treatment off stage Ib cervix cancer[J].Gynecol Oncology,1993,49(2):153-155.
5. 曹泽毅.子宫颈癌治疗的变迁和思考[S].第八届全国妇科肿瘤会议专题讲座.上海:2004:26.
6. TERMUNGRUANGLERT W, TRESUKOSOL D, VASURATNA A, et al. Neoadjuvant gemcitabine and cisplatin followed by radical surgery in(bulky) squamous cell carcinoma of cervix stage IB2[J]. Gynecol Oncol,2005,97:576 581.

West China Medical Journal

Clinical Effects of Neoadjuvant Chemotherapy on 36 Cases with Cervical Carcinoma

Abstract Full text Figures/Tables Video References Cited by

Format

Content