Histology of the Zymbal’s Gland in Different Aged SD Rats on Safety Evaluation of Preclinical Drugs_West China Medical Journal

Authors：

1.West China Hospital of Sichuan University, National Chengdu Center for Safety Evaluation of Drugs; 2.West China Frontier Pharma Technology; 3.West China School of Public Health, Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

SD大鼠; 外耳道腺; 药物; 评价

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目的:探讨大鼠外耳道腺的正常组织结构及年龄组间,雌雄动物间有无差异,以期为药物评价过程中药物对耳腺影响的评价提供客观的依据。方法:将20只同龄SD大鼠随即分为A和B两组,每组均雌雄各半,分别与12周和17周龄处死,取外耳道腺进行病理学分析。观察外耳道腺在不同年龄组间、雌雄组间有无区别。结果:A组动物雌雄组间外耳道腺的组织结构无明显差异。B组动物雌雄动物间外耳道腺的组织结构无明显差异。A组雌性动物与B组雌性动物间外耳道腺的组织结构无明显差异。A组雄性动物与B组雄性动物间外耳道腺的组织结构无明显差异。结论:SD大鼠外耳道腺的组织结构在雌雄动物间及年龄在12周及17周间无明显差异,因此在进行药物对耳腺的影响的评价过程中12周龄和17周龄的受试大鼠所得到的结果应具备可比性。

Citation： DU Yanchun,QIU Shuang,CHEN Ke,et al.. Histology of the Zymbal’s Gland in Different Aged SD Rats on Safety Evaluation of Preclinical Drugs. West China Medical Journal, 2009, 24(7): 1764-1766. doi: Copy

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1. SEELY J. Auditory sebaceous glands (Zymbal’s glands)[J]. Pathobiol Aging Rat,1994,2:423-433..
2. YAMAZAKI K, AISO S, MATSUMOTO M, et al. Carcinogenicity and chronic toxicity of 1,4dichloro 2nitrobenzene in rats and mice by two years feeding[J]. Ind Health,2006,44(2):230-243..
3. QUAST J F. Twoyear toxicity and oncogenicity study with acrylonitrile incorporated in the drinking water of rats[J]. Toxicol Letters,2002,132(3):153-196..
4. MEHLMAN M A. Carcinogenic effects of benzene: Cesare Maltoni’s contributions[J]. Ann N Y Acad Sci,2002,982:137-148..
5. FRIEDMAN M A, BELILES R P. Threegeneration reproduction study of rats receiving acrylonitrile in drinking water[J]. Toxicol Letters,2002,132(3):249-261..
6. BELPOGGI F, SOFFRITTI M, GUARINO M, et al. Results of longterm experimental studies on the carcinogenicity of ethylenebisdithiocarbamate (Mancozeb) in rats[J]. Ann N Y Acad Sci,2002,982:123-136..
7. MALTONI C, COTTI G, VALGIMIGLI L, et al. Zymbal gland carcinomas in rats following exposure to benzene by inhalation[J]. Am J Industrial Med,1982,3(1):11-16..
8. OWEN P E, GLAISTER J R, GAUNT I F, et al. Inhalation toxicity studies with 1,3butadiene. 3. Two year toxicity/carcinogenicity study in rats[J]. Am Ind Hyg Assoc J,1987,48(5):407-413..
9. TAKAYAMA S, NAKATSURU Y, SATO S. Carcinogenic effect of the simultaneous administration of five heterocyclic amines to F344 rats[J]. Jpn J Cancer Res,1987,78(10):1068-1072..

West China Medical Journal

Histology of the Zymbal’s Gland in Different Aged SD Rats on Safety Evaluation of Preclinical Drugs

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