TNF-α and Acute Lung Injury_West China Medical Journal

Authors：

LI Mengqin

the Department of Emergency, the Affiliated Hospital of North Sichuan Medical College, Nanchong Sichuan 637000, China;

Corresponding author：

Keywords：

急性肺损伤; 急性呼吸窘迫综合征; TNF-α; 抗TNF-α

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急性肺损伤(acute lung injury,ALI)是临床常见的呼吸系统急危重症,其发病机制复杂,病死率高。肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)是ALI发生、发展过程中非常重要的细胞因子。本文就TNF-α在ALI中的作用和以抗TNF-α为靶点治疗ALI的相关研究进行综述。

Citation： LI Mengqin,CAO Xiaoping.. TNF-α and Acute Lung Injury. West China Medical Journal, 2009, 24(7): 1896-1899. doi: Copy

1.
2.
3.
4.	SEMENZATO G. Tumor necrosis factor: a cytokine with multiple biological activities[J]. Br J Cancer,1990,61:354-361..
5.	章敬波,林建银,杨恬.医学细胞分子生物学[M].第1版.北京:中国协和医科大学出版社,2002:6548-5494..
6.	金惠铭,卢建,殷莲华.细胞分子病理生理学[M].第1版.郑州:郑州大学出版社,2002:173-174..
7.	刘红菊,李元桂,毕爱华.肿瘤坏死因子在急性肺损伤发病机制中的作用[J].国外医学免疫分册,1996,(5):229-231..
8.	OKAJIMA K. Regulation of inflammatory responses by endothelial cellsunderstanding the molecular mechanism(s) and its therapeutic application to sepsis[J]. Masui,2008,57(3):311-20..
9.	VELDHUIZEN E J, HAAGSMAN H P. Role of pulmonary surfactant components in surface film formation and dynamics[J]. Biochim Biophys Acta,2000,1467(2):255-270..
10.	BERHANE K, MARGANA R K, BOGGARAM V. Characterization of rabbit SPB promoter region responsive to downregulation by tumor necrosis factoralpha[J]. Am J Physiol Lung Cell Mol Physiol,2000,279(5):L806-814..
11.	MIAKOTINA O L, SNYDER J M. TNFalpha inhibits SPA gene expression in lung epithelial cells via p38 MAPK[J]. Am J Physiol Lung Cell Mol Physiol,2002,283(2):L418-427..
12.	WILCOX P, MILLIKEN C, BRESSLER B. Highdose tumor necrosis factor alpha produces an impairment of hamster diaphragm contractility. Attenuation with a prostaglandin inhibitor[J]. Am J Respir Crit Care Med,1996,153(5):1611-1615..
13.	WILCOX P, OSBORNE S, BRESSLER B. Monocyte inflammatory mediators impair in vitro hamster diaphragm contractility[J]. Am Rev Respir Dis,1992,146(2):462-466..
14.	SHERIDAN B C, MCINTYRE R C, MELDRUM D R, et al. Pentoxifylline treatment attenuates pulmonary vasomotor dysfunction in acute lung injury[J]. J Surg Res,1997,71(2):150-154..
15.	MEDURI G U, KOHLER G, HEADLEY S, et al. Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome[J]. Chest,1995,108(5):1303-1314..
16.	PARSONS P E, MATTHAY M A, WARE L B, et al. Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury[J]. Am J Physiol Lung Cell Mol Physiol,2005,288(3):L426-431..
17.	VAN RIEMSDIJKVAN OVERBEEKE I C, BAAN C C, NIESTERS H G M, et al. The TNFalpha system in heart failure and after heart transplantation: plasma protein levels, mRNA expression, soluble receptors and plasma buffer capacity[J]. Eur Heart J,1999,20(11):833-840..
18.	BOYLE E M Jr, CANTY T G Jr, MORGAN E N, et al. Treating myocardial ischemiareperfsion injury by targeting endothelial cell transcription[J]. Ann Thorac Surg,1999,68(5):19491953..
19.	SATO Y, HIRAMATSU Y, HOMMA S, et al. Phosphodiesterase type 4 inhibitor rolipram inhibits actibation of monocytes during extracorporeal circulation[J]. J Thorac Cardiovasc Surg,2005,130(2):346-350..
20.	SOUZA D G, CASSALI G D, POOLE S, et al. Effects of inhibition of PDE4 and TNFα on local and remote injuries following ischaemia and reperfusion injury[J]. Br J Pharmacol,2001,134(5):985-994. doi: 10.1038/sj.bjp.0704336..
21.	MALAZDREWICH C, THUMBIKAT P, ABRAHAMSEN M S, et al. Pharmacological inhibition of Mannheimia haemolytica lipopolysaccharide and leukotoxininduced cytokine expression in bovine alveolar macrophages[J]. Microb Pathog,2004,36(3):159-169..
22.	RBE C E, WILFERT F, UTHE D, et al. Modulation of radiationinduced tumor necrosis factor α (TNF-α) expression in the lung tissue pentoxifylline[J]. Radiother Oncol,2002,64(2):177-187.
23.	RUIZORTEGA M, LORENZO O, SUZUKI Y, et al. Proinflammatory actions of angiotensins[J]. Curr Opin Nephrol Hypertens,2001,10(3):321-329..
24.	YAO H W, MAO L G, ZHU J P. Protective effects of pravastatin in murine lipopolysaccharideinduced acue lung injury[J]. Clin Experiment Pharmacol Physiol,2006,33(9):793-797..
25.	GRIP O, JANCIAUSKIENE S, LINDGREN S. Pravastatin downregulates inflammatory mediators in human monocytes in vitro[J]. Eur J Pharmacol,2000,410(1):83-92..
26.	AMATO R J. Thalidomide: an antineoplastic agent[J]. Curr Oncol Rep,2002,4(1):56-62..
27.	MOREIRA A L, SAMPAIO E P, ZMUIDZINAS A, et al. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation[J]. J Exp Med,1993,177(6):1675-1680. doi: 10.1084/jem.177.6.16A75..
28.	ROCHA A C, FERNANDES E S, QUINTO N L, et al. Relevance of tumour necrosis factorα for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw[J]. Br J Pharmacol,2006,148(5):688-695..
29.	MUKHOPADHYAY S, HOIDAL J R, MUKHERJEE T K. Role of TNFα in pulmonary pathophysiology[J]. Respir Res,2006,7(1):125-127..
30.	GEARING A J, BECKETT P, CHRISTODOULOU M, et al. Processing of tumour necrosis factoralpha precursor by metalloproteinases[J]. Nature,1994,370(6490):555-557..
31.	CORBEL M, LANCHOU J, GERMAIN N, et al. Modulation of airway remodelingassociated mediators by the antifibrotic compound, pirfenidone, and the matrix metalloproteinase inhibitor, batimastat, during acute lung injury in mice[J]. Eur J Pharmacol,2001,426(1-2):113-121..
32.	EBERT E C. Infliximab and the TNFα system[J]. Am J Phisiol Gastrointest Liver Physiol,2009,296(3):G612-620..
33.	MUTLU G M, MUTLU E A, BELLMEYER A, et al. Pulmonary adverse events of antitumor necrosis factorα antibody therapy[J]. Am J Med,2006,119(8):639-646; Comment in: Am J Med,2007,120(12):e21; author reply e23..

1.
2.
3.
4. SEMENZATO G. Tumor necrosis factor: a cytokine with multiple biological activities[J]. Br J Cancer,1990,61:354-361..
5. 章敬波,林建银,杨恬.医学细胞分子生物学[M].第1版.北京:中国协和医科大学出版社,2002:6548-5494..
6. 金惠铭,卢建,殷莲华.细胞分子病理生理学[M].第1版.郑州:郑州大学出版社,2002:173-174..
7. 刘红菊,李元桂,毕爱华.肿瘤坏死因子在急性肺损伤发病机制中的作用[J].国外医学免疫分册,1996,(5):229-231..
8. OKAJIMA K. Regulation of inflammatory responses by endothelial cellsunderstanding the molecular mechanism(s) and its therapeutic application to sepsis[J]. Masui,2008,57(3):311-20..
9. VELDHUIZEN E J, HAAGSMAN H P. Role of pulmonary surfactant components in surface film formation and dynamics[J]. Biochim Biophys Acta,2000,1467(2):255-270..
10. BERHANE K, MARGANA R K, BOGGARAM V. Characterization of rabbit SPB promoter region responsive to downregulation by tumor necrosis factoralpha[J]. Am J Physiol Lung Cell Mol Physiol,2000,279(5):L806-814..
11. MIAKOTINA O L, SNYDER J M. TNFalpha inhibits SPA gene expression in lung epithelial cells via p38 MAPK[J]. Am J Physiol Lung Cell Mol Physiol,2002,283(2):L418-427..
12. WILCOX P, MILLIKEN C, BRESSLER B. Highdose tumor necrosis factor alpha produces an impairment of hamster diaphragm contractility. Attenuation with a prostaglandin inhibitor[J]. Am J Respir Crit Care Med,1996,153(5):1611-1615..
13. WILCOX P, OSBORNE S, BRESSLER B. Monocyte inflammatory mediators impair in vitro hamster diaphragm contractility[J]. Am Rev Respir Dis,1992,146(2):462-466..
14. SHERIDAN B C, MCINTYRE R C, MELDRUM D R, et al. Pentoxifylline treatment attenuates pulmonary vasomotor dysfunction in acute lung injury[J]. J Surg Res,1997,71(2):150-154..
15. MEDURI G U, KOHLER G, HEADLEY S, et al. Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome[J]. Chest,1995,108(5):1303-1314..
16. PARSONS P E, MATTHAY M A, WARE L B, et al. Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury[J]. Am J Physiol Lung Cell Mol Physiol,2005,288(3):L426-431..
17. VAN RIEMSDIJKVAN OVERBEEKE I C, BAAN C C, NIESTERS H G M, et al. The TNFalpha system in heart failure and after heart transplantation: plasma protein levels, mRNA expression, soluble receptors and plasma buffer capacity[J]. Eur Heart J,1999,20(11):833-840..
18. BOYLE E M Jr, CANTY T G Jr, MORGAN E N, et al. Treating myocardial ischemiareperfsion injury by targeting endothelial cell transcription[J]. Ann Thorac Surg,1999,68(5):19491953..
19. SATO Y, HIRAMATSU Y, HOMMA S, et al. Phosphodiesterase type 4 inhibitor rolipram inhibits actibation of monocytes during extracorporeal circulation[J]. J Thorac Cardiovasc Surg,2005,130(2):346-350..
20. SOUZA D G, CASSALI G D, POOLE S, et al. Effects of inhibition of PDE4 and TNFα on local and remote injuries following ischaemia and reperfusion injury[J]. Br J Pharmacol,2001,134(5):985-994. doi: 10.1038/sj.bjp.0704336..
21. MALAZDREWICH C, THUMBIKAT P, ABRAHAMSEN M S, et al. Pharmacological inhibition of Mannheimia haemolytica lipopolysaccharide and leukotoxininduced cytokine expression in bovine alveolar macrophages[J]. Microb Pathog,2004,36(3):159-169..
22. RBE C E, WILFERT F, UTHE D, et al. Modulation of radiationinduced tumor necrosis factor α (TNF-α) expression in the lung tissue pentoxifylline[J]. Radiother Oncol,2002,64(2):177-187.
23. RUIZORTEGA M, LORENZO O, SUZUKI Y, et al. Proinflammatory actions of angiotensins[J]. Curr Opin Nephrol Hypertens,2001,10(3):321-329..
24. YAO H W, MAO L G, ZHU J P. Protective effects of pravastatin in murine lipopolysaccharideinduced acue lung injury[J]. Clin Experiment Pharmacol Physiol,2006,33(9):793-797..
25. GRIP O, JANCIAUSKIENE S, LINDGREN S. Pravastatin downregulates inflammatory mediators in human monocytes in vitro[J]. Eur J Pharmacol,2000,410(1):83-92..
26. AMATO R J. Thalidomide: an antineoplastic agent[J]. Curr Oncol Rep,2002,4(1):56-62..
27. MOREIRA A L, SAMPAIO E P, ZMUIDZINAS A, et al. Thalidomide exerts its inhibitory action on tumor necrosis factor alpha by enhancing mRNA degradation[J]. J Exp Med,1993,177(6):1675-1680. doi: 10.1084/jem.177.6.16A75..
28. ROCHA A C, FERNANDES E S, QUINTO N L, et al. Relevance of tumour necrosis factorα for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw[J]. Br J Pharmacol,2006,148(5):688-695..
29. MUKHOPADHYAY S, HOIDAL J R, MUKHERJEE T K. Role of TNFα in pulmonary pathophysiology[J]. Respir Res,2006,7(1):125-127..
30. GEARING A J, BECKETT P, CHRISTODOULOU M, et al. Processing of tumour necrosis factoralpha precursor by metalloproteinases[J]. Nature,1994,370(6490):555-557..
31. CORBEL M, LANCHOU J, GERMAIN N, et al. Modulation of airway remodelingassociated mediators by the antifibrotic compound, pirfenidone, and the matrix metalloproteinase inhibitor, batimastat, during acute lung injury in mice[J]. Eur J Pharmacol,2001,426(1-2):113-121..
32. EBERT E C. Infliximab and the TNFα system[J]. Am J Phisiol Gastrointest Liver Physiol,2009,296(3):G612-620..
33. MUTLU G M, MUTLU E A, BELLMEYER A, et al. Pulmonary adverse events of antitumor necrosis factorα antibody therapy[J]. Am J Med,2006,119(8):639-646; Comment in: Am J Med,2007,120(12):e21; author reply e23..

West China Medical Journal

TNF-α and Acute Lung Injury

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