目的:观察A型肉毒毒素(BTXA)对面肌痉挛(HFS)患者痉挛程度的改善和生存质量的影响。方法: 对68例HFS患者进行局部注射BTXA,治疗前及治疗后1个月分别对患者的痉挛程度进行判定和使用世界卫生组织生存质量评定量表简表(WHOQOL-BREF)评价生存质量。 结果: 97.04%的HFS患者在BXTA治疗后1个月痉挛明显改善缓解,而且患者在WHOQOL-BREF的生理领域、心理领域、社会关系领域、总的健康状况和总的生存质量的评分均明显高于治疗前,差异有统计学意义(P lt;0.01)。 结论: 局部注射BTXA可迅速缓解或消除HFS患者肌肉痉挛,提高患者的生存质量。
Citation：
LI Qifu,ZHENG Hongbo,JIANG Yi.. Impact on Quality of Life of Botulinus Toxin A Injection for Hemifacial Spasm. West China Medical Journal, 2009, 24(8): 1923-1925. doi:
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Copyright © the editorial department of West China Medical Journal of West China Medical Publisher. All rights reserved
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SCOTT AB,KENNEDY RA,STUBBS HA.Botulinum A toxic injection as a treatment for blepharospasm[J].Arch Ophthalmol,1985,103:347-350.
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郝元涛,方积乾,李彩霞,等.世界卫生组织生存质量量表及其中文版介绍及其应用说明[J].国外医学社会医学分册,1999,16:118-122.
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JOST WH,KOHL A.Botulinum toxin:evidencebased medicine criteria in blepharospasm and hemifacial spasm[J].Neurol,2001,248:S21-S24.
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SCHANTZ EJ,JONSOS EA.Properties and use of botulinum toxin and other microtoxins in medicine[J].Mic Rev,1992,56:80.
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SUPUTTITADA A,PHANTHUMCHINDA K,LOCHARERNKUL C,et al.Hemifacial spasm:results of treatment with low dose botulinum toxin injection[J].J Med Assoc Thail,2004,87:12051211.
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| 7. |
SCHEIDT CE,SCHULLER B,RAYKI G,et al.Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm[J].Neurology,1996,47:43-45.
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| 8. |
SCHNIDER P,BIRNER P,MORARU E,et al.Longterm treatment with botulinum toxin:dosage,treatment schedules and costs[J]. Wiener Klinische Wochenschrift,1999,111:59-65.
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郝元涛,方积乾.世界卫生组织生存质量测定量表中文版介绍及其应用说明[J].现代康复,2000,4:1127-1129.
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| 10. |
WHOQOL Group.Development of the World Health Organization WHOQOLBREF quality of life assessment[J].Psychol Med,1998,28:551-558.
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| 11. |
钟萍,蒋毅. A型肉毒毒素治疗半侧面肌痉挛的临床疗效评价[J].现代生物医学进展,2006,6:44-45.
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- 1. SCOTT AB,KENNEDY RA,STUBBS HA.Botulinum A toxic injection as a treatment for blepharospasm[J].Arch Ophthalmol,1985,103:347-350.
- 2. COHEN DA,SAVINO P,STERN MB,et al.Botulinum injection therapy for blepharospasm:a review and report of 75 patients[J].Chn Neuropharmacol,1986,9:415.
- 3. 郝元涛,方积乾,李彩霞,等.世界卫生组织生存质量量表及其中文版介绍及其应用说明[J].国外医学社会医学分册,1999,16:118-122.
- 4. JOST WH,KOHL A.Botulinum toxin:evidencebased medicine criteria in blepharospasm and hemifacial spasm[J].Neurol,2001,248:S21-S24.
- 5. SCHANTZ EJ,JONSOS EA.Properties and use of botulinum toxin and other microtoxins in medicine[J].Mic Rev,1992,56:80.
- 6. SUPUTTITADA A,PHANTHUMCHINDA K,LOCHARERNKUL C,et al.Hemifacial spasm:results of treatment with low dose botulinum toxin injection[J].J Med Assoc Thail,2004,87:12051211.
- 7. SCHEIDT CE,SCHULLER B,RAYKI G,et al.Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm[J].Neurology,1996,47:43-45.
- 8. SCHNIDER P,BIRNER P,MORARU E,et al.Longterm treatment with botulinum toxin:dosage,treatment schedules and costs[J]. Wiener Klinische Wochenschrift,1999,111:59-65.
- 9. 郝元涛,方积乾.世界卫生组织生存质量测定量表中文版介绍及其应用说明[J].现代康复,2000,4:1127-1129.
- 10. WHOQOL Group.Development of the World Health Organization WHOQOLBREF quality of life assessment[J].Psychol Med,1998,28:551-558.
- 11. 钟萍,蒋毅. A型肉毒毒素治疗半侧面肌痉挛的临床疗效评价[J].现代生物医学进展,2006,6:44-45.
