The Relationship between Expression of KAI1/CD82 and E－cadherin and Prognosis of Colorectal Carcinoma_West China Medical Journal

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Department of Pathology,Yuebei People Hospital of Shaoguan,Shaoguan 512026, China;

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Keywords：

结直肠肿瘤; KAI1/CD82; E-cadherin; 预后

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目的:探讨结直肠癌KAI1/CD82与E－cadherin的表达与预后的关系。方法: 采用免疫组化S-P法检测105例结直肠癌中KAI1/CD82与E-cadherin的表达。结果: 74例中5年生存率为48.6%。生存5年以上的KAI1/CD82的阳性表达率(86.11%),明显高于生存5年以下者(57.89%)(P lt;0.01);而E－cadherin生存5年以上者的阳性表达率(6389%)亦明显高于生存5年以下者(31.58%)(P lt;0.01%)。结论:联合检测KAI1/CD82与E-cadherin的表达对临床判断结直肠癌的预后有重要价值。

Citation： LIU Wenqing,GAO Shuangquan,HUANG Wei,et al.. The Relationship between Expression of KAI1/CD82 and E－cadherin and Prognosis of Colorectal Carcinoma. West China Medical Journal, 2009, 24(8): 1954-1956. doi: Copy

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9.	JACKSON P,KINGSLEY EA,RUSSELL PJ.Inverse correlation between KAI1mRNA levels invasive behaviour in bladder cancer cell lines[J]. Cancer lett,2000,156(1):9-17.
10.	刘静,杨桂芳,龚玲玲,等. KAI1/CD82和E粘着糖蛋白及整合素β-1表达与胃癌侵袭转移的关系[J].中华病理学杂志,2007,36(8):558-559.

1. MUNEYUKI T,WATANABE M,YAMANAK M,et al. KAI1/CD82 expression as a prognostic factor in sporadic colorectal cancer[J].Amcicancer Res,2001,21(5):3581-3587.
2. MIYAZAKI T,KATO H, SHITARA Y,et al.Mutation and expression of the metastasis suppressor gene KAI1 in esphageal squamous cell carcinoma[J].Cancer,2000,89(5):955-962.
3. 简卫国,李凌. Ecadherin的生物学特性和临床意义[J].临床与实验病理学杂志,1998,14(5):502-503.
4. 全国大肠癌病理研究协作组.大肠癌病理研究统一规范[J].中华肿瘤杂志,1986,(2):186.
5. HUANG CL,KOHNO N,OGAWA E,et al.Correlation of reduction in MRP1/CD9 and KAI1/CD82 expression with recurrences in breast cancer patients[J].Am J Pathol,1998,153(3):973－982.
6. 刘莉,李祖国,杨之光,等.抑癌基因KAI1对大肠癌细胞生物学特征的影响[J].第一军医大学学报,2003,23(6):587－590.
7. MAURER CA,GIRABER HU,FRIESS H,et al.Reduced expression of the metasis suppressor gene KAI1 in advanced colon cancer and its metases[J].Surgery,1999,126(5):8690-880.
8. HANBY AM,CHINERY R,POULZOM R,et al.Downregulation of Ecadherin in the reparative epithelium of the human gastrointestinal tract[J].Am J Pathol,1996,148(3):723-729.
9. JACKSON P,KINGSLEY EA,RUSSELL PJ.Inverse correlation between KAI1mRNA levels invasive behaviour in bladder cancer cell lines[J]. Cancer lett,2000,156(1):9-17.
10. 刘静,杨桂芳,龚玲玲,等. KAI1/CD82和E粘着糖蛋白及整合素β-1表达与胃癌侵袭转移的关系[J].中华病理学杂志,2007,36(8):558-559.

West China Medical Journal

The Relationship between Expression of KAI1/CD82 and E－cadherin and Prognosis of Colorectal Carcinoma

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