Nocturnal Arrhythmia in Obstructive Sleep ApneaHypopnea Syndrome_West China Medical Journal

Authors：

WANG Yongsheng ¹ , LI Kai ² , LIANG Zongan. ³

1Department of Medicine,363 Hospital of Chengdu, Chengdu Sichuan 610041,China;

Corresponding author：

Keywords：

睡眠呼吸暂停; 心律失常; 多导睡眠图; 动态心电图

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目的:了解阻塞性睡眠呼吸暂停综合症(OSAHS)患者夜间心律失常的发生情况、常见类型及相关因素。方法:对67例睡眠打鼾患者同步进行动态心电图及多导睡眠图监测。以呼吸暂停指数及夜间最低氧饱和度将研究对象进行分组,比较分析夜间心律失常发生率及发生类型并进一步分析夜间心律失常的相关因素。结果:OSAS组的夜间心律失常发生率显著高于单纯鼾症患者。随着OSAS加重,呼吸暂停低通气指数逐渐增大,夜间氧饱和度下降越明显,心律失常发生率升高,发生时间延长、恶性程度增加,尤其以缓慢型心律失常的发生率增多。结论:OSAHS患者夜间心律失常的发生率及严重程度与OSAHS严重程度呈正相关,夜间心律失常的诱发与呼吸暂停低通气指数及低氧血症密切相关。应重视夜间心律失常患者合并存在的OSAHS的诊治。

Citation： WANG Yongsheng,LI Kai,LIANG Zongan.. Nocturnal Arrhythmia in Obstructive Sleep ApneaHypopnea Syndrome. West China Medical Journal, 2009, 24(8): 2020-2022. doi: Copy

1.	中华医学会呼吸病学分会睡眠呼吸疾病学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J].中华结核和呼吸杂志,2002, 25:195-198.
2.	HOFFSTEIN V, MATEI KA S. Cardiac arrhythmias, Snoring and sleep apnea[J]. Chest,1994, 106: 446.
3.	ALONSOFERNANDEZ A, GARCIARIO F, RRCIONERO M A, et al. Cardiac rhythm disturbances and STsegment depression episodes in patients with obstructive sleep apneahypopnea syndrome and its mechanisms.Chest.2005.127 (1); 15-22 .
4.	黄文,吕芳芳,史继红,等.阻塞性睡眠呼吸暂停综合征患者与心律失常的临床分析[J].山东大学基础医学院报,2004,18(3):140-142.
5.	GUILLEMINAULT C, CONNOLL S T, WINKLE RA. Cardiac arrhythmia and conduction disurbances during sleep in 400 patients with sleep apnea Syndrome[J]. A m J Cardiol,1983, 52: 490.
6.	BECKER J T, JR KLEIGER K E, FLEISS J L, et al. Components of heart rate variability measured during healing of acute myocardial infarction[J].Am J Cardiol,1988,61:208-215.
7.	鲁慧敏,杨玲,林建海. 阻塞性睡眠呼吸暂停综合征患者夜间低氧心律失常分析[J]. 同济大学学报(医学版),2006, 26(3):52-53.
8.	王璋,司良毅.睡眠呼吸暂停综合症致动脉内皮损伤的电镜研究[J].重庆医学,2005,34 (4):556.

1. 中华医学会呼吸病学分会睡眠呼吸疾病学组.阻塞性睡眠呼吸暂停低通气综合征诊治指南(草案)[J].中华结核和呼吸杂志,2002, 25:195-198.
2. HOFFSTEIN V, MATEI KA S. Cardiac arrhythmias, Snoring and sleep apnea[J]. Chest,1994, 106: 446.
3. ALONSOFERNANDEZ A, GARCIARIO F, RRCIONERO M A, et al. Cardiac rhythm disturbances and STsegment depression episodes in patients with obstructive sleep apneahypopnea syndrome and its mechanisms.Chest.2005.127 (1); 15-22 .
4. 黄文,吕芳芳,史继红,等.阻塞性睡眠呼吸暂停综合征患者与心律失常的临床分析[J].山东大学基础医学院报,2004,18(3):140-142.
5. GUILLEMINAULT C, CONNOLL S T, WINKLE RA. Cardiac arrhythmia and conduction disurbances during sleep in 400 patients with sleep apnea Syndrome[J]. A m J Cardiol,1983, 52: 490.
6. BECKER J T, JR KLEIGER K E, FLEISS J L, et al. Components of heart rate variability measured during healing of acute myocardial infarction[J].Am J Cardiol,1988,61:208-215.
7. 鲁慧敏,杨玲,林建海. 阻塞性睡眠呼吸暂停综合征患者夜间低氧心律失常分析[J]. 同济大学学报(医学版),2006, 26(3):52-53.
8. 王璋,司良毅.睡眠呼吸暂停综合症致动脉内皮损伤的电镜研究[J].重庆医学,2005,34 (4):556.

West China Medical Journal

Nocturnal Arrhythmia in Obstructive Sleep ApneaHypopnea Syndrome

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